Microwave-Enhanced Efficient Synthesis of Diversified 3,6-Disubstituted Pyridazines

Crystal structure of 3,6-di-2-pyridinyl-4-pyridazine carbonitrile, C15H9N5

“…These nitrogen atoms o er a unique chemistry as the nitrogen atoms interact with suitable substrates with acidic functionalities to generate novel supramolecular assemblies with exotic structures [6][7][8][9]. They also act as building blocks in several …”

Enhancing the cellular anti-proliferation activity of pyridazinones as c-met inhibitors using docking analysis

“…Pyridazinones 9, employed as starting materials in these routes, were either commercially available or prepared utilizing previously described procedures [39]. Aniline ring containing intermediates 11 were generated from 9 by using sequences involving alkylation with chloromethyl-nitrobenzene followed by nitro group reduction.…”

“…1), occupy the ATP binding pocket utilizing a 'U'-shaped conformation whereas class II inhibitors, exemplified by 3, adopt an extended conformation binding to their protein counterparts. Studies in our group over the past several years have focused on the discovery of bioactive compounds possessing pyridazine or pyridazinone scaffolds [39]. The results of an early high throughout screening (HTS) effort led to the identification of pyridazinone 4 as a modestly potent c-Met inhibitor with an IC 50 value of ca.…”

Effect of pyridazine content and crosslinker structure on the properties of polyurethane elastomers

“…Pyridazines are heterocyclic compounds with an NN bond in their ring structure. Pyridazines are also known to exhibit biological activities such as antibacterial, antibiotic, analgesic, antiviral, anti‐inflammatory effects, etc 20. Thus, due to their structure, reactivity, and their tendency to form stable compounds, pyridazine derivatives have been the subject of extensive research—particularly in the pharmaceutical and agrochemical areas—because of their useful biological properties 21,22…”

“…Pyridazines are also known to exhibit biological activities such as antibacterial, antibiotic, analgesic, anti-viral, anti-inflammatory effects, etc. 20 Thus, due to their structure, reactivity, and their tendency to form stable compounds, pyridazine derivatives have been the subject of extensive research-particularly in the pharmaceutical and agrochemical areas-because of their useful biological properties. 21,22 In this article we obtained PUs with a heterocyclic structure in main chain and place into discussion the effect of incorporating various pyridazine content and different crosslinkers structures into the backbone chains of the PU films.…”