Microwave-assisted synthesized zinc nanoparticles attenuate cisplatin-induced testicular toxicity in mice

Shakibaie, Mojtaba; Forootanfar, Hamid; Jafari, Elham; Salimi, Azad; Doostmohammadi, Mohsen; Rahimi, Hamid Reza

doi:10.1080/02772248.2020.1789135

Cited by 4 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Determination of serum testosterone levels was one of these hormones that can be used to measure testicular function and diagnose male infertility (40). According to the data obtained from this study, the rate of serum testosterone in the cisplatin-treated group showed a signi cant decrease, which is consistent with the results of studies by Shakibaie et al (2020) and Mnati et al (2020) was consistent (29,41). Decreased testosterone levels may be due to the effect of cisplatin on the function of Leydig cells.…”

Section: Discussionsupporting

confidence: 91%

The effect of Sambucus nigra fruit extract in three chemotropic cycles of cisplatin drug on male reproductive system of mice

Esmaeli,

Ghanbari,

Roshankhah

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Administration of chemotherapeutic agents, such as cisplatin, induces infertility as a side effect in men of childbearing age, while consumption of antioxidants can recover this process. Therefore, the present study was designed to evaluate the protective effect of Sambucus nigra (SNA) on cisplatin alone and in combination in reducing the toxicity of cisplatin on the reproductive system of mice. Materials & methods In this study, 30 adult balb/c mice were randomly divided into 5 groups (n = 6). Mice in the groups received cisplatin (0.4 mg/kg) and SNA (200 mg/kg) intraperitoneally for three periods of six days with an interval of 10 days for a total of 48 days. The positive and negative control groups received normal saline and no drug, respectively. At the end of the treatment period, various parameters such as semen analysis, changes in testicular histological structures, changes in hormone levels, expression of apoptotic genes and the amount of malondialdehyde (MDA), total superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) were evaluated. Results The results of the present study showed that SNA could significantly reduce abnormalities of sperm and testis due to cisplatin administration. In addition, SNA was able to reduce the expression of genes involved in the apoptotic pathway compared to the cisplatin group. Meanwhile, SNA reduced serum MDA rate and raised rate T-SOD, GSH-Px and CAT rate compared to the cisplatin group. Conclusion The findings of this study suggest that SNA may have a protective effect against cisplatin in testicular tissue via its antioxidant properties.

show abstract

Section: Discussionsupporting

confidence: 91%

The effect of Sambucus nigra fruit extract in three chemotropic cycles of cisplatin drug on male reproductive system of mice

Esmaeli,

Ghanbari,

Roshankhah

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Regarding the findings of the present study, the cisplatin-treated group showed a remarkable and significant diminish in serum LH and FSH level when compared with the control group. These results were consisted with Shakibaie et al (2020) [26] , who found that a single injection of cisplatin can reduce gonadotropic hormone levels (LH and FSH) within lab animals. Anterior pituitary gland secret LH in response to GnRH which in turn stimulates Leydig cells to produce testosterone.…”

Section: Discussionsupporting

confidence: 58%

The Testicular Protection Effect of Thiamine Pyrophosphate Against Cisplatin-treated Male Rats

Mnati

Mshimesh

Mohammed

2022

AJPS

View full text Add to dashboard Cite

Infertility is a worldwide problem affecting both genders, it can be defined as the inability of the adult males to make a fertile woman pregnant after one year of regular intercourse. Cisplatin considers one of the most potent antineoplastic drugs that is extensively used, alone or in combination with other antitumor agents, to manage solid and germ cell cancer. The major drawback in cisplatin treatment is its damaging consequence on various body tissue, including the testis, liver, renal and others. One of its pronounced adverse effects is testicular injury, which may proceed to end with infertility. Thiamine pyrophosphate is the active form of thiamine which has an important role in the oxidative phosphorylation pathway. It acts as a co-factor and energy source for many cellular enzymes, also it utilizes by pentose-phosphate shut that elevates NADPH and improves antioxidants level. This study aimed to evaluate the effect of thiamine pyrophosphate on sperm parameters and gonadotropic hormones (luteal and follicle-stimulating hormone) of male rats exposed to a single dose of cisplatin. Twenty-eight albino male rats were randomly grouped into four groups. Control group: received normal saline, Cisplatin group: received normal saline and cisplatin, TPP50 group: received thiamine pyrophosphate (50mg/kg) with cisplatin, and TPP100 group: as third group (TPP50) but thiamine pyrophosphate dose was 100 mg/kg. Semen samples used to measure the sperms viability and morphology, while serum samples were gathered to measure the levels of gonadotropic hormones (FSH and LH). This study revealed that rat’s testicular function was notably deteriorated by cisplatin administration, represented by a reduction in sperm parameters (viability and normal morphology), and serum gonadotropic hormones (FSH and LH). In this work, thiamine pyrophosphate was act as a protective agent that ameliorates rat’s testicular damage induced by cisplatin in a dose-dependent manner. The suggested mechanism may attribute to its antioxidant and anti-apoptotic action

show abstract

Natural products against cisplatin‐induced male reproductive toxicity: A comprehensive review

Rahimi

Asadi

Rezghi

et al. 2021

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Cisplatin is widely used as one of the most effective anticancer agents in the treatment of some neoplasms. Reproductive toxicity is the most common outcome associated with cisplatin testicular damage. Alternative natural medicines for treating male testicular disorders and infertility have received extensive attention in research. Natural products, medicinal herbs, and their secondary metabolites have been shown as promising agents in the management of testicular damage induced by chemotherapy drugs. This study aimed to review the research related to natural substances that are promising in mitigation of the cisplatin‐induced toxicity in the reproductive system. PubMed and Scopus were searched for studies on various natural products for their potential protective property against reproductive toxicity induced by cisplatin from 2000 to 2020. Eligibility was checked based on selection criteria. Fifty‐nine articles were included in this review. Mainly in animal studies, several natural agents have positively affected cisplatin‐reproductive‐toxicity factors, including reactive oxygen species, inflammatory mediators, DNA damage, and activation of the mitochondrial apoptotic pathway. Most of the natural agents were investigated in short‐term duration and high doses of cisplatin exposure, considering their antioxidant activity against oxidative stress. Considering antioxidant properties, various natural products might be effective for the management of cisplatin reproductive toxicity. However, long‐term recovery of spermatogenesis and management of low‐dose‐cisplatin toxicity should be considered as well as the bioavailability of these agents before and after treatment with cisplatin without affecting its anticancer activity.

show abstract

Microwave-assisted synthesized zinc nanoparticles attenuate cisplatin-induced testicular toxicity in mice

Cited by 4 publications

References 33 publications

The effect of Sambucus nigra fruit extract in three chemotropic cycles of cisplatin drug on male reproductive system of mice

The effect of Sambucus nigra fruit extract in three chemotropic cycles of cisplatin drug on male reproductive system of mice

The Testicular Protection Effect of Thiamine Pyrophosphate Against Cisplatin-treated Male Rats

Natural products against cisplatin‐induced male reproductive toxicity: A comprehensive review

Contact Info

Product

Resources

About