Natural products against cisplatin‐induced male reproductive toxicity: A comprehensive review

Abstract

Cisplatin is widely used as one of the most effective anticancer agents in the treatment of some neoplasms. Reproductive toxicity is the most common outcome associated with cisplatin testicular damage. Alternative natural medicines for treating male testicular disorders and infertility have received extensive attention in research. Natural products, medicinal herbs, and their secondary metabolites have been shown as promising agents in the management of testicular damage induced by chemotherapy drugs. This study aimed to review the research related to natural substances that are promising in mitigation of the cisplatin‐induced toxicity in the reproductive system. PubMed and Scopus were searched for studies on various natural products for their potential protective property against reproductive toxicity induced by cisplatin from 2000 to 2020. Eligibility was checked based on selection criteria. Fifty‐nine articles were included in this review. Mainly in animal studies, several natural agents have positively affected cisplatin‐reproductive‐toxicity factors, including reactive oxygen species, inflammatory mediators, DNA damage, and activation of the mitochondrial apoptotic pathway. Most of the natural agents were investigated in short‐term duration and high doses of cisplatin exposure, considering their antioxidant activity against oxidative stress. Considering antioxidant properties, various natural products might be effective for the management of cisplatin reproductive toxicity. However, long‐term recovery of spermatogenesis and management of low‐dose‐cisplatin toxicity should be considered as well as the bioavailability of these agents before and after treatment with cisplatin without affecting its anticancer activity.

Roles of adipose-derived stem cells and derived exosomes in therapeutic applications to testicular injury caused by cisplatin

“…Cisplatin can induce the production of reactive oxygen species (ROS) and reduce the activity of antioxidant enzymes, leading to oxidative stress and damage to testicular cells [ 1 ]. In addition, cisplatin can activate the Nuclear factor kappa-B (NF-κB) signaling pathway and increase the expression of pro-inflammatory cytokines, leading to inflammation and tissue damage [ 19 ]. Furthermore, cisplatin can directly damage DNA and induce apoptosis in testicular cells [ 15 ].…”

“…In addition, cisplatin can activate the Nuclear factor kappa-B (NF-κB) signaling pathway and increase the expression of pro-inflammatory cytokines, leading to inflammation and tissue damage [19]. Furthermore, cisplatin can directly damage DNA and induce apoptosis in testicular cells [15].…”

Laherradurin Inhibits Tumor Growth in an Azoxymethane/Dextran Sulfate Sodium Colorectal Cancer Model In Vivo

“…Such is the case of cisplatin, which causes mainly nephrotoxic damage, with over 30% of patients presenting acute and chronic renal lesions [59]. Moreover, cisplatin could induce neurotoxicity, hepatotoxicity, ototoxicity, and testicular damage [60][61][62][63].…”