Microwave-assisted synthesis of pyrrolidinone derivatives using 1,1’-butylenebis(3-sulfo-3H-imidazol-1-ium) chloride in ethylene glycol

Abstract

The energy efficiency of the microwave-assisted synthesis of pyrrolidinones was demonstrated using catalytic loading of 1,1’-butylene-bis(3-sulfo-3H-imidazol-1-ium) chloride as a sulfonic acid functionalized ionic liquid in ethylene glycol as green solvent. The effect of electron donating and electron withdrawing groups on aniline derivatives was studied under conventional heating and microwave irradiation. Furthermore, the cation effect of ionic liquids containing sulfonic groups on the catalytic efficiency for the synthesis of ethyl-1-phenyl-2-(4-chlorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyr-role-3-carboxylate was investigated under conventional heat. The experimental results exhibited that there is a relationship between catalytic efficiency and the number of sulfonic groups and imidazolium moieties linked by carbon spacer.

Malic acid as an effective and valuable bioorganocatalyst for one-pot, three-component synthesis of pyrrolidinone derivatives

“…In view of their biological significance, the construction of these frameworks and their structural analogues have attracted much attention. [6][7][8][9][10][11][12][13][14] Cotinine, 15 Doxapram, 16 Ethosuximide, 17 and PI-091, 18 are examples of some drugs containing the pyrrolidinone core. Some natural products have a pyrrolidinone scaffold, such as Lactacystin, 19 Holomycin, and Thiolutin, 20 Thiomarinol A4, 21 Oteromycin, 22 Pyrrocidine A, B, 23 Quinolactacin C, 24 Ypaoamide, 25 (−)-Azaspirene, 26 and Salinosporamide A.…”

“…In this work, we have introduced malic acid as a green-chemistry bioorganocatalyst for the synthesis of some pyrrolidinone derivatives. [9][10][11]14,36 Malic acid is known as a fruit acid that plays a role in creating the sour taste of the fruits. Apples contain a lot of malic acid, called apple extract.…”