Microwave-assisted synthesis of polypyridyl ruthenium(<scp>ii</scp>) complexes as potential tumor-targeting inhibitors against the migration and invasion of Hela cells through G2/M phase arrest

Cao, Jieqiong; Wu, Qiong; Zheng, Wenjie; Li, Li; Mei, Wenjie

doi:10.1039/c7ra00658f

Cited by 13 publications

(7 citation statements)

References 42 publications

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“…The following step consisted in the direct reaction of (phen) 2 RuCl 2 with the bidentate L ′ ligand in ethylene glycol, under microwave irradiation. With respect to conventional heating methods, the use of the microwave assisted technology permits to improve the yield of the compound and effectively reduces the reaction time . In our case in fact, L was formed after heating the reaction mixture at 160 °C for only 7 minutes.…”

Section: Resultssupporting

confidence: 84%

“…With respect to conventionalh eating methods, the use of the microwave assisted technology permits to improvet he yield of the compound and effectively reduces the reaction time. [21,22] In our case in fact, L was formed after heating the reactionm ixture at 160 8Cf or only 7minutes.W ec an assumet hat this process is also facilitated by the labilityo ft he two chloride ligands,w hich allows their replacement by the bidentate ligand L'.…”

Section: Resultsmentioning

confidence: 50%

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Highly Charged Ruthenium(II) Polypyridyl Complexes as Effective Photosensitizer in Photodynamic Therapy

Conti

Bencini

Ferrante

et al. 2019

Chemistry A European J

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A comparative study between two novel, highly water soluble, ruthenium(II) polypyridyl complexes, [Ru(phen)2L′] and [Ru(phen)2Cu(II)L′] (L and L‐CuII), containing the polyaazamacrocyclic unit 4,4′‐(2,5,8,11,14‐pentaaza[15])‐2,2′‐bipyridilophane (L′), is herein reported. L and L‐CuII interact with calf‐thymus DNA and efficiently cleave DNA plasmid when light‐activated. They also possess great penetration abilities and photo‐induced biological activities, evaluated on an A375 human melanoma cell line, with L‐CuII being the most effective. Our study highlights the key role of the Fenton active CuII center within the macrocycle framework, that would play a synergistic role with light activation in the formation of cytotoxic ROS species. Based on these results, an optimal design of RuII polypyridyl systems featuring specific CuII‐chelating polyamine units could represent a suitable strategy for the development of novel and effective photosensitizers in photodynamic therapy.

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Section: Resultssupporting

confidence: 84%

Section: Resultsmentioning

confidence: 50%

Highly Charged Ruthenium(II) Polypyridyl Complexes as Effective Photosensitizer in Photodynamic Therapy

Conti

Bencini

Ferrante

et al. 2019

Chemistry A European J

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“…Considering the death caused by cancer recurrence due to the high invasion and metastasis feature of HeLa tumors, 45 metastasis of all groups in the liver was analyzed to evaluate late recurrence on the 16th day after termination of treatment. As observed in Figure 7B, all groups could find different numbers of metastatic nodules except for the SQU@PCN + hv group (Figure 7B1,B2).…”

Section: Results and Discussionmentioning

confidence: 99%

An ATP-Regulated Ion Transport Nanosystem for Homeostatic Perturbation Therapy and Sensitizing Photodynamic Therapy by Autophagy Inhibition of Tumors

Wan

Zhang

2019

ACS Cent. Sci.

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In this article, an adenosine-triphosphate-regulated (ATP-regulated) ion transport nanosystem [SQU@PCN, porphyrinic porous coordination network (PCN) incorporated with squaramide (SQU)] was designed and synthesized for homeostatic perturbation therapy (HPT) and sensitizing photodynamic therapy (PDT) of tumors. It was found that this nanotransporter SQU@PCN easily accumulated in tumor sites while avoiding metabolic clearance and side effects. In response to a high expression of ATP in the tumor, SQU@PCN was decomposed because of the strong coordination of ATP with metal ligand of PCN. Subsequently, incorporated SQU was released and then simultaneously transported chloride ions across membrane of the cell and lysosome along with the chloride ion concentration gradient. On one hand, influx of chloride ions by SQU increased intracellular ion concentration, which disrupted ion homeostasis and further induced tumor cell apoptosis. On the other hand, SQU-medicated coupling transport of H + /Cl – across the lysosomal membrane alkalized the lysosome, resulting in inhibition of autophagy. This SQU-mediated autophagy inhibition would sensitize PCN-based PDT since activated autophagy by traditional PDT would resist and weaken the therapeutic efficacy. In vivo animal test results revealed that combined HPT and sensitized PDT could realize tumor eradication while blocking metastasis, which provided a paradigm for complementary multimodal tumor treatment.

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“…It is noteworthy that using the microwave for longer periods of time under the above-mentioned conditions resulted in a significant decrease in the yield of the reaction, possibly due to some interactions of the final product with other molecules present in the reaction mixture. Only few examples of microwave-assisted syntheses of ruthenium complexes were previously reported [51][52][53]. The synthesis of cationic complex 2, RuCp(PPh 3 ) 2 (ATZ)BF 4 , was performed by reacting RuCp(PPh 3 ) 2 Cl and anastrozole in the presence of AgBF 4 in refluxing acetone for 2h (36% yield).…”

Section: Resultsmentioning

confidence: 99%

Synthesis and biological assessment of a ruthenium(II) cyclopentadienyl complex in breast cancer cells and on the development of zebrafish embryos

Golbaghi

Pitard

Lucas

et al. 2020

European Journal of Medicinal Chemistry

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Ruthenium-based complexes currently attract great attention as they hold promise to replace platinum-based drugs as a first line cancer treatment. Whereas ruthenium arene complexes are some of the most studied species for their potential anticancer properties, other types of ruthenium complexes have been overlooked for this purpose. Here, we report the synthesis and characterization of Ru(II) cyclopentadienyl (Cp), Ru(II) cyclooctadienyl (COD) and Ru(III) complexes bearing anastrozole or letrozole ligands, third-generation aromatase inhibitors currently used to treat estrogen receptor-positive (ER+) breast cancer. Among these complexes, Ru(II)Cp 2 was the only species found to be stable in DMSO and in cell culture media and as a result, the only complex for which the in vitro and in vivo biological activities were investigated. Unlike anastrozole alone, complex 2 was considerably cytotoxic in vitro (IC50 values < 1μM) in human Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Microwave-assisted synthesis of polypyridyl ruthenium(ii) complexes as potential tumor-targeting inhibitors against the migration and invasion of Hela cells through G2/M phase arrest

Abstract: The polypyridyl ruthenium(ii) complexes 4 was identified as a potential inhibitor against the migration and invasion of Hela cells, which could selectively accumulate in tumors tissue and induce G2/M phase arrest in cancer cells.

Cited by 13 publications

References 42 publications

Highly Charged Ruthenium(II) Polypyridyl Complexes as Effective Photosensitizer in Photodynamic Therapy

Highly Charged Ruthenium(II) Polypyridyl Complexes as Effective Photosensitizer in Photodynamic Therapy

An ATP-Regulated Ion Transport Nanosystem for Homeostatic Perturbation Therapy and Sensitizing Photodynamic Therapy by Autophagy Inhibition of Tumors

Synthesis and biological assessment of a ruthenium(II) cyclopentadienyl complex in breast cancer cells and on the development of zebrafish embryos

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