Ruthenium-based complexes currently attract great attention as they hold promise to replace platinum-based drugs as a first line cancer treatment. Whereas ruthenium arene complexes are some of the most studied species for their potential anticancer properties, other types of ruthenium complexes have been overlooked for this purpose. Here, we report the synthesis and characterization of Ru(II) cyclopentadienyl (Cp), Ru(II) cyclooctadienyl (COD) and Ru(III) complexes bearing anastrozole or letrozole ligands, third-generation aromatase inhibitors currently used to treat estrogen receptor-positive (ER+) breast cancer. Among these complexes, Ru(II)Cp 2 was the only species found to be stable in DMSO and in cell culture media and as a result, the only complex for which the in vitro and in vivo biological activities were investigated. Unlike anastrozole alone, complex 2 was considerably cytotoxic in vitro (IC50 values < 1μM) in human Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

This paper focuses on the numerical and experimental characterization of the vortex structures that develop along a simplified geometry of a wing equipped with pylon-mounted engine at low speed/high angle of attack flight conditions. In these conditions, the presence of the engine installation under the wing induces a complex and unsteady vortical flow field at the nacelle/pylon/wing junctions which interacts with the upper wing boundary layer and leads to a drop of aircraft performances. In order to gain insight into the physics driving this interaction, it is proposed to isolate its fundamental mechanisms by simplifying the problem. The parameters of interest that led to the simplification of the model are first described. As a first step into a more comprehensive knowledge of this complex physics, this study is initially conducted at a Reynolds number of 200000, based on the chord wing and on the free stream velocity. Two configurations of angle of attack and sideslip angles (α = 8°/β = 0° and α = 8°/β = 30°) have been investigated. This work relies on unsteady RANS computations, oil flow visualizations and 3C-PIV measurements. The vortex dynamics thus produced is described in terms of vortex core position, intensity, size and turbulent intensity thanks to a vortex tracking post-processing algorithm. In addition, the analysis of the velocity flow field obtained from the PIV measurements will highlight the influence of the longitudinal vortex issued from the pylon/wing junction on the separation process of the boundary layer near the upper wing leading-edge.

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