Microwave-Assisted Synthesis of Novel 1,3,4-Thiadiazolyl-Substituted 1,2,4-Triazines as Potential Antitubercular Agents

Kidwai, Mazaahir; Kumar, Rajesh; Srivastava, A. K.; Gupta, H. P.

doi:10.1006/bioo.1998.1108

Cited by 17 publications

(7 citation statements)

References 9 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many substituted five-membered heterocycle pyrazoles, 1,2,4-triazoles and 1,3,4-thiadiazoles are known to posses a wide range of pharmacological activities, such as antibacterial [1][2][3], anticonvulsant [4][5][6], and antitubercular [7][8] activities. Moreover, the pyrazole nucleus ranks among those molecular structures related to potent analgesic activity [9][10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Some Novel Azo Derivatives of 3,5‐Dimethly‐1‐(2‐hydroxyethyl)pyrazole as Potent Analgesic Agents

Oruç

Koçyığıt‐Kaymakcioğlu

Oral

et al. 2006

Archiv der Pharmazie

View full text Add to dashboard Cite

A series of 1-(2-hydroxyethyl)-3,5-dimethylpyrazolylazo derivatives, incorporating thiosemicarbazide 2a-c, 1,3,4-thiadiazole 3a-c, and 1,2,4-triazole-3-thione 4a-c were synthesized. The structure of these novel synthesized compounds 2a-c, 3a-c, and 4a-c was confirmed by spectral analysis. All these compounds were screened for their analgesic activity. Hot-plate and tail-immersion tests were used for the determination of the analgesic activity. Morphine, an analgesic through both spinal and supraspinal pathways, was used as a standard test drug. All compounds were administered at a dose of 100 mg/kg i.p. Among the compounds, 2-(butylamino)-5-[((1-(2-hydroxyethyl)-3,5-dimethylpyrazole-4-yl)azo)phenyl]-1,3,4-thiadiazole 3a and 4-[((1-(2-hydroxyethyl)-3,5-dimethylpyrazole-4-yl)azo)phenyl]-4-(2-phenethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 4c showed analgesic effects in both tests. Especially 4c exerted strong analgesia starting at 30 min after injection.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis of Some Novel Azo Derivatives of 3,5‐Dimethly‐1‐(2‐hydroxyethyl)pyrazole as Potent Analgesic Agents

Oruç

Koçyığıt‐Kaymakcioğlu

Oral

et al. 2006

Archiv der Pharmazie

View full text Add to dashboard Cite

show abstract

“…The filtrate was kept at 20°C, and colorless crystals of [Ag(AMTT) 2 ]NO 3 were separated. IR spectrum (cm -1 ): 1585 sec (n CN), 1474 sec (n as NO 3 [Cu(AMTT)] n Cl n . AMTT (0.66 g, 5 mmol) was added to a solution of 0.41 g (2.0 mmol) of CuC1 2 × 2H 2 O in 60 mL of H 2 O.…”

Section: Synthesis Of Complexesmentioning

confidence: 99%

Synthesis of Ag(I) and Cu(I) Complexes with 4-Amino-5-Methyl-2h-1,2,4-Triazole-3(4h)-Thione Ligand as Thiocarbohydrazide Derivatives and their Antimicrobial Activity

et al. 2015

View full text Add to dashboard Cite

The antimicrobial activity of 4-amino-5-methyl-2H-1,2,4-triazole-3(4H)-thione (AMTT) and its silver(I) and copper(I) complexes has been investigated. Results show that MIC50 and MIC90 of the organic ligand against all test strains were higher than MIC50 and MIC90 of both complexes. The minimum MIC50 of the silver complex, copper complex, and the ligand against Candida albicans and Aspergillus niger were 5.6, 10.3, and 12.5 mg/mL, respectively. The MIC50 and MIC90 of the silver complex were lower than those of the copper complex against Candida albicans, Aspergillus niger, Escherichia coli, and Pseudomonas aeruginosa. At the same time, the MIC50 of the silver complex is higher than that of the copper complex against Staphylococcus aureus.

show abstract

“…During the past fifteen years there is a tremendous growth and efforts to prepare organic 37 , inorganic and organometallic compounds via green chemical approach.…”

Section: Microwave Heating In Drug Discoverymentioning

confidence: 99%

Green Revolution in Chemistry by Microwave Assisted Synthesis: A Review

Belwal¹

2013

View full text Add to dashboard Cite

Green chemistry efficiently utilizes raw materials (preferably renewable), eliminates waste, and avoids the use of toxic or hazardous reagents and solvents in the manufacture and application of chemical products. Microwave assisted technique opens up new opportunities to the synthetic chemist in the form of new reactions that are not feasible using conventional heating and serve a flexible platform for chemical reactions. Over the past five years there has been a dramatic uptake in the use of microwaves as an energy source to promote synthetic transformations. Microwave-assisted synthesis (MAOS) is clearly a method by which the laboratory chemist can achieve goals in a fraction of the time as compared to traditional conductive heating methods. Reaction times in the best cases have been reduced from hours or days to minutes. The basic mechanisms observed in microwave assisted synthesis are dipolar polarization and conduction. The technique offers a simple, clean, fast, efficient, and economic way for the synthesis of a large number of molecules, providing the momentum for many chemists to switch from traditional heating methods to microwave assisted chemistry. In the present article an attempt was made to focus on what is microwave assisted synthesis, how is it generated and what importance may it have.

show abstract

Microwave-Assisted Synthesis of Novel 1,3,4-Thiadiazolyl-Substituted 1,2,4-Triazines as Potential Antitubercular Agents

Cited by 17 publications

References 9 publications

Synthesis of Some Novel Azo Derivatives of 3,5‐Dimethly‐1‐(2‐hydroxyethyl)pyrazole as Potent Analgesic Agents

Synthesis of Some Novel Azo Derivatives of 3,5‐Dimethly‐1‐(2‐hydroxyethyl)pyrazole as Potent Analgesic Agents

Synthesis of Ag(I) and Cu(I) Complexes with 4-Amino-5-Methyl-2h-1,2,4-Triazole-3(4h)-Thione Ligand as Thiocarbohydrazide Derivatives and their Antimicrobial Activity

Green Revolution in Chemistry by Microwave Assisted Synthesis: A Review

Contact Info

Product

Resources

About