Synthesis of Ag(I) and Cu(I) Complexes with 4-Amino-5-Methyl-2h-1,2,4-Triazole-3(4h)-Thione Ligand as Thiocarbohydrazide Derivatives and their Antimicrobial Activity

Ghaneian, MT; Tabatabaee, Masoumeh; Ehrampoush, Mohammad Hassan; Jebali, Ali; Hekmatimoghaddam, Seyedhossein; Fallahzadeh, Hossin; Fallahzadeh, Reza Ali

doi:10.1007/s11094-015-1258-0

Cited by 14 publications

(6 citation statements)

References 15 publications

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“…The antibacterial activity of ethanolic extract may be related to the high level of known components with antibiotic properties as phytol against E. coli, S. typhimurium, S. aureus, antifungicidal viz. C. albicans, A. niger [23][24][25][26]; squalene against S. aureus [27]; β-amyrin against B. subtilis, S. aureus, E. coli, S. typhimurium, in total they make up 15.44 % [28,29].…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Contents, Antimicrobial and Antioxidant Properties of Gnaphalium uliginosum L. Ethanolic Extract and Essential Oil for Agricultural Uses

et al. 2019

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Gnaphalium uliginosum L. (Asteraceae) is widely used in phytotherapy and has a potential for agricultural utilization. The ethanolic extract was obtained from the maceration of air-dried plants, and the extract was then filtered and concentrated using a rotary evaporator. The essential oil was pressed from freshly harvested and crushed, aerial part of plants. The chemical compositions of ethanolic extract and essential oil of G. uliginosum L. (EOG) were investigated using gas chromatography/mass spectrometry (GC/MS). Nine constituents accounted for 77.3 % of the total detected components were determined at the ethanolic extract with a high proportion of sterols 42.8%, fatty acids 24.1 %, triterpenes 14.4 %. Twenty constituents were identified in essential oil of G. uliginosum L.; with α-pinene and estragole accounting for 54.0 %. The ethanolic extract was found to have a moderate antimicrobial activity (MIC values varied from 125 to 500 μg/mL), for S. aureus, B. cereus and A. solani significant activity (less than 62.5 μg/mL). The essential oil was found to have a moderate (MICs 500-1000 μg/mL) and strong activities (31.3-250 μg/mL). The antioxidant activity was evaluated using chemiluminescent assay. The ethanolic extract of G. uliginosum L. acted as a medium-strength antioxidant at concentrations of less than 0.1 mg/mL. The essential oil made be regarded as a weak strength antioxidant.

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Section: Resultsmentioning

confidence: 99%

Phytochemical Contents, Antimicrobial and Antioxidant Properties of Gnaphalium uliginosum L. Ethanolic Extract and Essential Oil for Agricultural Uses

et al. 2019

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“…Phytol has been reported to possess antimicrobial activities, toxicity on mouse skin cells and a high repellent activity against Anopheles gambiae (Nerio et al, 2012;Ghaneian et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

Extraction and bioactivity from Jatropha Curcas L. leaves by steam distillation.

Soto-Armenta¹,

Sacramento-Rivero²,

González-Coloma⊥³

et al. 2018

PAK.J.BOT.

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Jatropha curcas L. has biological activities that can contribute to find new products. In this study, steam distillation at laboratory scale was applied to J. curcas leaves to assess the yield of essential oil and the bioactivity of the hydrolate. The effect of steam flow and bed porosity on the extraction yield was also determined, where it was observed that residence time was one of the influential factors in the yield of essential oil. The extracts were analyzed by GC-MS. Dibutyl phthalate, phytol, and diisooctyl phthalate were the majoritarian components. Research reports indicate that these components have biological activity. The greatest yield obtained was 0.38% on a dry weight basis. The bioassays showed that the hydrolate of J. curcas possessed toxicity against Spodoptera littoralis, Myzus persicae, Lactuca sativa, and Lolium perenne. The bioactivity of these products should be further explored, they have a promising future as a biocontroller.

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“…It seems that the precise mechanism has not been defined yet. Ghaneian et al found that garlic extract with a good selectivity index value has inhibitory effects on the virus penetration and proliferation in cell culture [20].…”

Section: Discussionmentioning

confidence: 99%

Quantitative Structure-Activity Relationships and Molecular Docking Simulation of Allicin Compounds as Inhibitors of COVID-19 Protease Enzyme

Piri

Hajialilo²,

Ghermezi³

et al. 2021

The Journal of Qazvin University of Medical Sciences

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Background: Coronavirus (CoV) is a group of viruses that cause disease in humans and animals. These viruses contain crown-shaped spike glycoproteins on their surface. Objective: We conducted a quantitative structure-activity relationship (QSAR) study on a series of 36 compounds of allicin to assess their antiviral activities against the main protease of COVID-19. Methods: In the present descriptive-analytic study, the information on the structure of compounds, the COVID-19 protease enzyme, and the Allicin derivatives was obtained from the databases such as the Research Collaboratory for Structural Bioinformatics’ Protein Data Bank (PDB) and PubChem. The QSAR method, analysis of correlations and multiple linear regressions were carried out. Six molecular descriptors such as constitutional and molecular topology descriptors were selected for the model. Finally, molecular docking was performed in iGEMDOCK 2.1 software. Results: The obtained multi-parametric model reported a correlation coefficient of about 0.89, indicating that the model was able to satisfactory predict the antiviral activity of allicin compounds. Conclusion: The findings obtained can be valuable in designing, synthesizing, and developing novel antiviral agents with allicin-based scaffold.

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Synthesis of Ag(I) and Cu(I) Complexes with 4-Amino-5-Methyl-2h-1,2,4-Triazole-3(4h)-Thione Ligand as Thiocarbohydrazide Derivatives and their Antimicrobial Activity

Cited by 14 publications

References 15 publications

Phytochemical Contents, Antimicrobial and Antioxidant Properties of Gnaphalium uliginosum L. Ethanolic Extract and Essential Oil for Agricultural Uses

Phytochemical Contents, Antimicrobial and Antioxidant Properties of Gnaphalium uliginosum L. Ethanolic Extract and Essential Oil for Agricultural Uses

Extraction and bioactivity from Jatropha Curcas L. leaves by steam distillation.

Quantitative Structure-Activity Relationships and Molecular Docking Simulation of Allicin Compounds as Inhibitors of COVID-19 Protease Enzyme

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