Microwave assisted synthesis of negative-charge carbon dots with potential antibacterial activity against multi-drug resistant bacteria

Kung, Jung-Chang; Tseng, I-Ting; Chien, Chi-Sheng; Lin, Su‐Hsia; Wang, Chun-Chi; Shih, Chi‐Jen

doi:10.1039/d0ra07106d

Cited by 30 publications

(23 citation statements)

References 32 publications

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“…The surface potentials of the different passivated CDs, namely, SCD, PEG_SCD, PEI_SCD, and FA_SCD, were found to be −14.2 ± 4.84, −12.0 ± 8.48, 15.5 ± 9.13, and 37.2 ± 7.32 mV (Figure S8), respectively, which is in accordance with their intrinsic charges of the functional group. The negative charge on the surface of SCD and PEG_SCD could arise due to the residual hydroxyl groups after carbonization, , while positive charge on PEI_SCD and FA_SCD was due to the intrinsic positive charge of the cationic polymer PEI, which is widely used as a positive passivating agent . The toxicity of CDs was evaluated on mouse fibroblast L929 cell lines (Figure a).…”

Section: Resultsmentioning

confidence: 99%

Influence of Surface States on the Optical and Cellular Property of Thermally Stable Red Emissive Graphitic Carbon Dots

Singh

Bahadur

Rangara

et al. 2021

ACS Appl. Bio Mater.

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Red emissive carbon dots from sucrose (SCD) were synthesized using a facile, isolation-free, one-pot method via microwave pyrolysis. Various passivation agents were used along with sucrose, and a relative change in the chemical and optical properties of the carbon dots was investigated. A detailed systematic study of the effect of various passivations, different solvents, pHs, and temperatures on optical properties was carried out. The influence of excitation wavelength and passivation on photoluminescence (PL) is discussed considering the functional groups associated with the passivating agents. The effect of different solvents on dispersibility and PL behavior has been understood in terms of the dielectric properties of the solvents. The decrease in PL intensity of SCD from pH 3 to 11 facilitates pH sensing. The PL of SCD was found to be essentially stable between the temperature range of 20 and 80 °C. Additionally, the effects of physicochemical properties with respect to passivation, such as charge and surface chemistry in determining the cellular uptake and cytotoxicity, are also addressed. Aside from sensors, the potential of SCDs as bioimaging agents has also been studied for mammalian cells. Moreover, SCD exhibits excellent PL stability investigated under different storage conditions for 15 days.

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Section: Resultsmentioning

confidence: 99%

Influence of Surface States on the Optical and Cellular Property of Thermally Stable Red Emissive Graphitic Carbon Dots

Singh

Bahadur

Rangara

et al. 2021

ACS Appl. Bio Mater.

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“…The precursors are mainly natural biomass, antibiotic drugs, and chemicals. [79][80][81][82][83][84][85][86][87][88][89][90][91][92][93][94][95][96][97] From Table 1, the antimicrobial effect of CDs synthesized by biomass is not outstanding. Most MIC values are between 100 and 1000 μg/ml, but they always possess excellent biocompatibility.…”

Section: Effect Of Precursorsmentioning

confidence: 99%

“…Table 1 summarizes the antibacterial activity, bacteriostatic species, and antibacterial conditions of different precursor synthetic CDs. The precursors are mainly natural biomass, antibiotic drugs, and chemicals 79–97 …”

Section: Impact Factors Of Cds Antimicrobial Activitymentioning

confidence: 99%

Recent advances of carbon dots as new antimicrobial agents

Sun

Xue

et al. 2022

SmartMat

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Due to the COVID-19 pandemic, many rapid antimicrobial agents have developed intensively. Carbon dots (CDs), a new type of carbon-based nanomaterials, shows great potential against emerging infectious diseases and antimicrobial-resistant infections due to their unique optical properties, excellent biocompatibility, and easy surface modification. With the definition of the CDs structure and properties, synthesis, and characteristic technology improvement, the research on the CDs as antimicrobial agents has made significant progress. However, the lack of high repeatable and exact preparation methods, and the regular antimicrobial activity make it far from practical application. In this review, we summarize the most recent progress and challenges of CDs antimicrobial. First, an overview of the characteristics and properties is given, and the advantage of CDs applied to antimicrobial is further discussed. Then, it focuses on research progress on antimicrobial mechanisms under different conditions, the critical factors affecting their antimicrobial activity, and the practical antimicrobial applications. Finally, the main challenges and future research perspectives of antimicrobial CDs are proposed.

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“…Many current examples in the literature of antimicrobial CDs exhibit broad antimicrobial activity against MDR bacteria (such as those made from citric acid [ 89 ] and protamine sulfate [ 90 ]). Whereas this feature may be useful for environmental and surface sanitation purposes, high selectivity towards a specific bacteria target is desired for in vivo applications to avoid off-target effects.…”

Section: Cds As Bacteria Targeting and Antibacterial Agentsmentioning

confidence: 99%

Carbon Dots as an Emergent Class of Antimicrobial Agents

2021

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Antimicrobial resistance is a recognized global challenge. Tools for bacterial detection can combat antimicrobial resistance by facilitating evidence-based antibiotic prescribing, thus avoiding their overprescription, which contributes to the spread of resistance. Unfortunately, traditional culture-based identification methods take at least a day, while emerging alternatives are limited by high cost and a requirement for skilled operators. Moreover, photodynamic inactivation of bacteria promoted by photosensitisers could be considered as one of the most promising strategies in the fight against multidrug resistance pathogens. In this context, carbon dots (CDs) have been identified as a promising class of photosensitiser nanomaterials for the specific detection and inactivation of different bacterial species. CDs possess exceptional and tuneable chemical and photoelectric properties that make them excellent candidates for antibacterial theranostic applications, such as great chemical stability, high water solubility, low toxicity and excellent biocompatibility. In this review, we will summarize the most recent advances on the use of CDs as antimicrobial agents, including the most commonly used methodologies for CD and CD/composites syntheses and their antibacterial properties in both in vitro and in vivo models developed in the last 3 years.

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Microwave assisted synthesis of negative-charge carbon dots with potential antibacterial activity against multi-drug resistant bacteria

Abstract: In this research, negative-charge carbon dots (CDs) were synthesized in one-step using a microwave and found to have potential antibacterial ability against multi-drug resistant bacteria.

Cited by 30 publications

References 32 publications

Influence of Surface States on the Optical and Cellular Property of Thermally Stable Red Emissive Graphitic Carbon Dots

Influence of Surface States on the Optical and Cellular Property of Thermally Stable Red Emissive Graphitic Carbon Dots

Recent advances of carbon dots as new antimicrobial agents

Carbon Dots as an Emergent Class of Antimicrobial Agents

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