Microwave‐assisted Synthesis of Hybrid Heterocyclics as Biological Potent Molecules

Srinivas, A.; Sunitha, M.; Reddy, Koduri Vasumathi; Karthik, P.; Kumar, G. Rajesh

doi:10.1002/jhet.3187

Cited by 12 publications

(7 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tiwari and co-workers [41] reported the synthesis of a series of glycosyl triazoles and their evaluation as efficient ligands in Cheteroatom coupling reactions by using a mono-O-isopropylidene glucofuranose derivative as starting material. Srinivas et al [42,43] reported a 1,2,3-triazole-linked allofuranose compound that can be a key intermediary in the preparation of a series of heterocyclic-containing carbohydrate-triazole hybrids with potential antimicrobial activity. The synthesis of such compounds involves a selective acidic hydrolysis of the corresponding acetonide to yield a chiral diol.…”

Section: Resultsmentioning

confidence: 99%

“…Srinivas et al . [ 42 , 43 ] reported a 1,2,3-triazole-linked allofuranose compound that can be a key intermediary in the preparation of a series of heterocyclic-containing carbohydrate–triazole hybrids with potential antimicrobial activity. The synthesis of such compounds involves a selective acidic hydrolysis of the corresponding acetonide to yield a chiral diol.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Cu–Al mixed oxide-catalysed multi-component synthesis of gluco- and allofuranose-linked 1,2,3-triazole derivatives

et al. 2020

View full text Add to dashboard Cite

A series of carbohydrate-linked 1,2,3-triazole derivatives were synthesized in good yields from glucofuranose and allofuranose diacetonides using as key step a three-component 1,3-dipolar azide–alkyne cycloaddition catalysed by a Cu–Al mixed oxide. In this multi-component reaction, Cu–Al mixed oxide/sodium ascorbate system serves as a highly reactive, recyclable and efficient heterogeneous catalyst for the regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles. The reported protocol has significant advantages over classical CuI/ N , N -diisopropylethylamine (DIPEA) or CuSO 4 /sodium ascorbate conditions in terms of efficiency and reduced synthetic complexity. In addition, the selective deprotection of synthesized di- O -isopropylidene derivatives was also carried out leading to the corresponding mono- O -isopropylidene products in moderate yields. Some of the synthesized triazole glycoconjugates were tested for their in vitro antimicrobial activity using the disc diffusion method against Gram-positive bacteria ( Staphylococcus aureus and Bacillus subtilis ), Gram-negative bacteria ( Escherichia coli and Pseudomonas aeruginosa ), as well as fungus ( Aspergillus niger ) and yeast ( Candida utilis ). The results revealed that these compounds exhibit moderate to good antimicrobial activity mainly against Gram-negative bacteria.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Cu–Al mixed oxide-catalysed multi-component synthesis of gluco- and allofuranose-linked 1,2,3-triazole derivatives

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Following the successful introduction of antimicrobial and nematicidal agents, inspired by the biological profile of triazoles, thiazolidenones, and in the continuation of our work on biologically active heterocycles, [27][28][29][30][31][32][33][34][35][36][37][38][39] we have developed a series of novel triazole linked thiazolidenone derivatives, and evaluated their nematicidal activity along with antibacterial activity.…”

Section: Srinivas Et Al: Synthesis and Biological Evaluation mentioning

confidence: 99%

Synthesis and Biological Evaluation of Triazole linked Thiazolidenone Glycosides

Srinivas

Madavarapu²,

Sunitha³

et al. 2016

ACSi

View full text Add to dashboard Cite

In a one pot procedure a series of novel triazole linked thiazolidinone derivatives 8a-g and 9a-g was prepared by condensation of (3aR,5S,6R,6aR]dioxole-5-carbaldehyde 7 with mercapto acids and primary amines in the presence of ZnCl 2 under both microwave irradiation and conventional heating conditions. Compound 7 was prepared from diacetone D-glucose with oxidation followed by reduction, click reaction, primary acetonide deprotection and with oxidative cleavage. Characterization of new compounds has been done by means of IR, NMR, MS and elemental analysis. The nematicidal and antibacterial activity of the compounds has also been evaluated.

show abstract

“…Following the successful introduction of antimicrobial and nematicidal agents, inspired by the biological profile of triazoles, thiazolidinones, isoxazoles, and their increasing importance in pharmaceutical and biological fields and in continuation of our work on biological active molecules and in order to enhance the biological activity of triazoles, thiazolidinones and isoxazoles moieties, it was thought to interest to accommodate triazole, thiazolidinones, and isoxazoles moieties in single molecular framework. In this article, we wish to report the synthesis of a new class of hybrid heterocyclics 10a–g in good yields and their evaluated in vitro antifungal and nematicidal activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and In Vitro Study of Hybrid Heterocyclic's as Potential Nematicidal Agents

Srinivas¹,

Sunitha²,

Karthik³

et al. 2017

Journal of Heterocyclic Chem

Self Cite

View full text Add to dashboard Cite

A series of novel 5‐((3aR,5S,6S,6aR)‐6‐((1‐(4‐chlorophenyl)‐1H‐1,2,3‐triazol‐4‐yl)methoxy)‐2,2‐dimethyltetrahydrofuro[2,3‐d][1,3]dioxol‐5‐yl)‐3‐(4‐fluorophenyl)‐6‐phenyl‐3,3a,5,6‐tetrahydroisoxazolo[3,4‐d]thiazoles 10a–g were synthesized by the reaction of chalcone derivatives of 2‐((3aR,5S,6S,6aR)‐6‐((1‐(4‐chlorophenyl)‐1H‐1,2,3‐triazol‐4‐yl)methoxy)‐2,2‐dimethyltetrahydrofuro[2,3‐d][1,3]dioxol‐5‐yl)‐3‐phenylthiazolidin‐4‐one 9 with hydroxylamine hydrochloride. The chemical structures of newly synthesized compounds were elucidated by IR, NMR, MS, and elemental analysis. The compounds 10 a–g were evaluated for their nematicidal activity against Dietylenchus myceliophagus and Caenorhabditis elegans; compound 10e and 10f showed appreciable nematicidal activity. Further, the compounds 10a – g were screened for their antifungal activity against Candida albicans (ATCC 10231), Aspergillus fumigates (HIC 6094), Trichophyton rubrum (IFO 9185), and Trichopyton mentagrophytes (IFO 40996). The compounds 10b and 10f displayed notable antifungal activity against all the microorganisms employed. The activity of these compounds is almost equal to the standard. It is also interesting to note that the compounds 10b and 10f and 10g showed activity towards C. albicans at the concentration of 3.75 μM, which is less than the concentration of the standard Amphotericin B.

show abstract

Microwave‐assisted Synthesis of Hybrid Heterocyclics as Biological Potent Molecules

Cited by 12 publications

References 56 publications

Cu–Al mixed oxide-catalysed multi-component synthesis of gluco- and allofuranose-linked 1,2,3-triazole derivatives

Cu–Al mixed oxide-catalysed multi-component synthesis of gluco- and allofuranose-linked 1,2,3-triazole derivatives

Synthesis and Biological Evaluation of Triazole linked Thiazolidenone Glycosides

Synthesis and In Vitro Study of Hybrid Heterocyclic's as Potential Nematicidal Agents

Contact Info

Product

Resources

About