Microwave-Assisted Synthesis of Dibenzo-Crown Ethers

Torrejos, Rey Eliseo C.; Nisola, Grace M.; Beltran, Arnel B.; Park, Myoung Jun; Patil, Basavaraj R.; Lee, Seong‐Poong; Seo, Jeong Gil; Chung, Wook–Jin

doi:10.2174/15701786113106660075

Cited by 8 publications

(3 citation statements)

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“…Intermediate 1 (1, 3-bis (2-hydroxyphenoxy) propane) in Fig. 1 and hydroxy-DB14C4 were synthesized according to the procedures described previously (Bartsch et al, 1983;Heo et al, 1981;Pedersen, 1967;Torrejos et al, 2014a).…”

Section: Reagentsmentioning

confidence: 99%

Liquid-liquid extraction of lithium using lipophilic dibenzo-14-crown-4 ether carboxylic acid in hydrophobic room temperature ionic liquid

Torrejos¹,

Nisola²,

Song

et al. 2016

Hydrometallurgy

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Section: Reagentsmentioning

confidence: 99%

Liquid-liquid extraction of lithium using lipophilic dibenzo-14-crown-4 ether carboxylic acid in hydrophobic room temperature ionic liquid

Torrejos¹,

Nisola²,

Song

et al. 2016

Hydrometallurgy

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“…S1) [31,32]. The solid support MWCNTs (>95 wt%, 20-30 nm outer diameter, 0.5-2 lm length, <1.5 wt% ash content) used in this experiment was acquired from Cheap Tubes, Inc. (Brattleboro, USA).…”

Section: Methodsmentioning

confidence: 99%

Synthesis and characterization of multi-walled carbon nanotubes-supported dibenzo-14-crown-4 ether with proton ionizable carboxyl sidearm as Li+ adsorbents

Torrejos¹,

Nisola²,

Park

et al. 2015

Chemical Engineering Journal

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“…Torrejos et al reported the MW-assisted synthesis of symmetric and asymmetric dibenzo-crown ethers in 2014 [ 128 ]. Specifically, symmetric dibenzo-crown ethers 142 (n = 1) and 146 can also be synthesized via one-pot synthesis from catechol and dibromopropane or dichloroethyl ether under basic conditions and MW irradiation with shorter reaction times and fewer purification steps, whereas asymmetric dibenzo-crown ethers 142 (n = 0), 143 , and 145 were obtained from two-step MW-assisted synthesis via the diphenol intermediates 141 and 144 , with satisfactory yields ( Scheme 43 ).…”

Section: Microwave-assisted And/or Solid-supported Synthesis Of Macro...mentioning

confidence: 99%

Recent Advances in Macrocyclic Drugs and Microwave-Assisted and/or Solid-Supported Synthesis of Macrocycles

Sun

2022

Molecules

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Macrocycles represent attractive candidates in organic synthesis and drug discovery. Since 2014, nineteen macrocyclic drugs, including three radiopharmaceuticals, have been approved by FDA for the treatment of bacterial and viral infections, cancer, obesity, immunosuppression, etc. As such, new synthetic methodologies and high throughput chemistry (e.g., microwave-assisted and/or solid-phase synthesis) to access various macrocycle entities have attracted great interest in this chemical space. This article serves as an update on our previous review related to macrocyclic drugs and new synthetic strategies toward macrocycles (Molecules, 2013, 18, 6230). In this work, I first reviewed recent FDA-approved macrocyclic drugs since 2014, followed by new advances in macrocycle synthesis using high throughput chemistry, including microwave-assisted and/or solid-supported macrocyclization strategies. Examples and highlights of macrocyclization include macrolactonization and macrolactamization, transition-metal catalyzed olefin ring-closure metathesis, intramolecular C–C and C–heteroatom cross-coupling, copper- or ruthenium-catalyzed azide–alkyne cycloaddition, intramolecular SNAr or SN2 nucleophilic substitution, condensation reaction, and multi-component reaction-mediated macrocyclization, and covering the literature since 2010.

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Microwave-Assisted Synthesis of Dibenzo-Crown Ethers

Cited by 8 publications

References 0 publications

Liquid-liquid extraction of lithium using lipophilic dibenzo-14-crown-4 ether carboxylic acid in hydrophobic room temperature ionic liquid

Liquid-liquid extraction of lithium using lipophilic dibenzo-14-crown-4 ether carboxylic acid in hydrophobic room temperature ionic liquid

Synthesis and characterization of multi-walled carbon nanotubes-supported dibenzo-14-crown-4 ether with proton ionizable carboxyl sidearm as Li+ adsorbents

Recent Advances in Macrocyclic Drugs and Microwave-Assisted and/or Solid-Supported Synthesis of Macrocycles

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