Microwave-Assisted Synthesis of 3-Styrylchromones in Alkaline Ionic Liquid

Abstract

A simple, highly efficient and environmentally benign method for the synthesis of 3-styrylchromones from 3-formylchromones and 4-nitrophenylacetic acid/4-nitrotolune in the presence of catalytic amount of basic ionic liquid 1-butyl-3-methylimidazolium hydroxide [(bmim)OH] carried out under the influence of microwave irradiation. This method gives remarkable advantages such as, short reaction times, simple work-up procedure and moderate to good yields. The ionic liquid was successfully reused for four cycles without significant loss of activity.

Copper borate (CuB4O7)-promoted multi-component green synthesis of 2,4,5-triarylimidazole derivatives and evidence of in situ conversion of copper borate (CuB4O7) into Cu(OAc)2 in the presence of NH4OAc

“…Comparisons of efficacy of CuB 4 O 7 with those of the reported catalysts 70–91 for the synthesis of 2,4,5-trisubstituted imidazole have shown that the present system involving CuB 4 O 7 has proven to be more efficient in terms of the short reaction time, milder reaction condition, and product yields (Table 4).…”

Ultrasound-Assisted, BF3·OEt2-Promoted, Multicomponent Synthesis of Chromene-Based Podophyllotoxin Analogues

“…Consequently, the reaction conditions used in the synthesis of chromene derivatives from dimedone may not be suitable when tetronic acid is used as the 1,3-dicarbonyl compound. 20 21 22 23…”

The Beneficial Sinergy of MW Irradiation and Ionic Liquids in Catalysis of Organic Reactions

“…The basic [bmim]OH IL catalyzed the synthesis of 3-styrylchromones from 3-formylchromones and a carbanion precursor, under MW irradiation [104] (Scheme 35). The authors pointed at the advantages of the method (easy work-up, short reaction times, satisfactory yields, reusable catalyst) and at the cytotoxicity of products.…”