Microwave-Assisted Synthesis, In Vivo Anti-Inflammatory and In Vitro Anti-Oxidant Activities, and Molecular Docking Study of New Substituted Schiff Base Derivatives

Simple and Efficient Green Methods Involving Microwaves and Mechanochemistry for Synthesis of a Schiff Ligand, 3, 3′-([1,1′-Biphenyl]-4,4′- Diylbis(azanylylidene))bis(indolin-2-One) With Antimicrobial Activity

“…Electromagnetic microwaves are an unconventional alternative for activating chemical reactions, either in the presence of the solvent or in its absence. Recently, some Schiff bases have been prepared using microwaves in the presence of the organic solvent [16,21] or in the absence of the solvent [22,23]. Green chemistry or sustainable chemistry is the field which is oriented towards obtaining chemical products by ecological methods, which minimize the use and generation of materials dangerous for the environment.…”

“…Schiff bases exhibits many pharmacological properties. Of these important are antibacterial activity [8,9], antiviral effect [10,11], antimalarial action [12], antifungal efficacy [13], anticancer therapy [14], antioxidant potency [15,16], and anti-inflammatory efficiency [16][17][18]. The conventional synthesis of Schiff bases is achieved by condensation of carbonyl compounds, aldehydes or ketones, with primary amines.…”

“…Unconventional methods have also been used to obtain Schiff bases. Of these we can mention microwave irradiation of the chemical medium containing solvent [16,21] and solvent-free microwave irradiation [22,23], ultrasound irradiation [24], and mechanochemical reactions [25][26][27]. We synthesized a Schiff base, 3,3'-([1,1'-biphenyl]-4,4'-diylbis(azanylylidene))bis(indolin-2-one), starting from 1H-indole-2,3-dione and 1,1'-biphenyl-4,4'-diamine.…”

Synthesis and cytotoxicity evaluation of pyrazole compounds bearing oxazepine core against breast cancer cells

“…The azomethine group has replaced the carbonyl group, and the nitrogen atom is attached to an aryl or alkyl (1). They are antimicrobial (2), antituberculosis (3), anti-cancer (4), antioxidant (5), anti-inflammatory (6), antifungal (7), and corrosion inhibitors (8). Oxazepines are a class of heterocyclic compounds that own seven-membered rings with two heteroatoms (O, N).…”

Chemistry and Biological Activities of 1,2,4-Triazolethiones—Antiviral and Anti-Infective Drugs

“…1,2,4-triazolethiones have been prepared successfully by various methods. The most common classical method is the dehydrative cyclization of different hydrazinecarbothioamides in presence of basic media using various reagents such as sodium hydroxide [ 2 , 25 , 33 ], potassium hydroxide [ 34 , 35 ], sodium bicarbonate [ 36 ] or acidic ionic liquid [ 37 ] followed by neutralization either with acid or base for both cases, in addition to different other techniques including donor–acceptor interactions. Various synthetic routes and biological applications of spiro-1,2,4-triazolethiones were also discussed as main heterocyclic targets easily obtained from different hydrazinecarbothioamides [ 38 , 39 ].…”