2020
DOI: 10.1590/s2175-97902019000318111
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Microwave-assisted synthesis and pharmacological screening of some triazolothiadiazole derivatives

Abstract: In this study, twenty-two new [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazoles (5a-n, 6a-h) were synthesized under microwave irradiation (MWI). The chemical structures of the compounds were elucidated by their IR, 1 H-NMR, LC-MS, and elemental analysis. The compounds were tested for antinociceptive activity by using the tail clip, tail flick, hot plate, and writhing methods in mice. The varying levels of antinociceptive activity of the compounds were compared with those of aspirin. Among these compounds, compound 5… Show more

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“…anticonvulsant [6], antidepressant [7], antiviral [8], anti-inflammatory [9], antinociceptive [10], antidiabetic and antioxidant [11], anticancer [12] agents. In addition, the structure of 1,2,4-triazole is resistant to metabolic transformations and is able to participate in the formation of intermolecular chemical bonds [13].…”
Section: Introductionmentioning
confidence: 99%
“…anticonvulsant [6], antidepressant [7], antiviral [8], anti-inflammatory [9], antinociceptive [10], antidiabetic and antioxidant [11], anticancer [12] agents. In addition, the structure of 1,2,4-triazole is resistant to metabolic transformations and is able to participate in the formation of intermolecular chemical bonds [13].…”
Section: Introductionmentioning
confidence: 99%