2022
DOI: 10.33483/jfpau.971602
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Synthesis, Properties and Biological Potential Some Condensed Derivatives 1,2,4-Triazole

Abstract: Objective:The aim of the work was to develop effective methods for the synthesis of biologically active heterocyclic systems containing pyrrole, indole and 1,2,4-triazole. In this study, firstly fourteen [1,2,4]triazolo [3,4-b][1,3,4]thiadiazoles compounds requiring for this study were synthesized.Material and Method: Chemical structures of synthesized compounds were characterized with elemental analysis, 1 H NMR, LC-MS techniques. The biological potential of the synthesized substances was estimated by the mol… Show more

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Cited by 5 publications
(9 citation statements)
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“…The resulting sediment was filtered and dried. [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazoles (8)(9)(10)(11)(12)(13)(14) To 0.01 mol of the initial 4-amino-5-(5-(4-methoxyphenyl) pyrazole-3-yl)-1,2,4-triazole-3-thiol, 0.01 mol of the corresponding carboxylic acid (benzoic, 2-methoxy-, 3-methoxybenzoic, 2-chlorobenzoic, 2-bromo-5-methoxybenzoic, 2-bromo-4-fluorobenzoic, 2-bromo-5-nitrobenzoic) and 15 ml of POCl 3 was added and heated for 3 hours at the temperature of 80 °C. After cooling, the solution was poured onto the ice.…”
Section: Resultsmentioning
confidence: 99%
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“…The resulting sediment was filtered and dried. [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazoles (8)(9)(10)(11)(12)(13)(14) To 0.01 mol of the initial 4-amino-5-(5-(4-methoxyphenyl) pyrazole-3-yl)-1,2,4-triazole-3-thiol, 0.01 mol of the corresponding carboxylic acid (benzoic, 2-methoxy-, 3-methoxybenzoic, 2-chlorobenzoic, 2-bromo-5-methoxybenzoic, 2-bromo-4-fluorobenzoic, 2-bromo-5-nitrobenzoic) and 15 ml of POCl 3 was added and heated for 3 hours at the temperature of 80 °C. After cooling, the solution was poured onto the ice.…”
Section: Resultsmentioning
confidence: 99%
“…The combination of different heterocyclic fragments with pharmacophore properties in one molecule makes it possible to use in practice the basic principles of the hybrid pharmacophore method for constructing molecules that are promising from the point of view of Pharmacology [1][2][3][4][5][6][7][8][9]. This approach allows you to achieve the necessary pharmacological effect, influence the indicators of toxicity and selectivity of action [10][11][12][13][14][15]. Recently, there has been an increased interest in the study of condensed heterocyclic systems.…”
Section: актуальні питання фармацевтичної і медичної науки та практик...mentioning
confidence: 99%
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