Microwave assisted synthesis and characterization of acrylamide grafted gellan, application in drug delivery

Vijan, Veena; Kaity, Santanu; Biswas, Soumen; Isaac, Jinu; Ghosh, Animesh

doi:10.1016/j.carbpol.2012.05.071

Cited by 139 publications

(56 citation statements)

References 21 publications

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“…This study was conducted for safety assessment of the hydrogel as drug carrier through oral route. In this case Mandal et al (2009) and Vijan et al (2012) already reported that PAM and its composite showed no signs of acute oral toxicity. On the other hand, BC which was extracted from nata de coco was a food grade material.…”

Section: In Vitro Cytotoxicity Studymentioning

confidence: 50%

See 1 more Smart Citation

Cytotoxicity and Acute Gastrointestinal Toxicity of Bacterial Cellulose-Poly (acrylamide-sodium acrylate) Hydrogel: A Carrier for Oral Drug Delivery

Pandey¹,

Choudhury²,

Amin³

2016

Pharm Sci

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Section: In Vitro Cytotoxicity Studymentioning

confidence: 50%

“…So, limit test was performed according to OECD guidelines. 7,9 All mice survived throughout the study period. There were no episodes of vomit, salivation and diarrhea as well as the feces was normal without pus and blood.…”

Section: In Vitro Cytotoxicity Studymentioning

confidence: 99%

Cytotoxicity and Acute Gastrointestinal Toxicity of Bacterial Cellulose-Poly (acrylamide-sodium acrylate) Hydrogel: A Carrier for Oral Drug Delivery

Pandey¹,

Choudhury²,

Amin³

2016

Pharm Sci

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“…Acrylamide grafted GG (AAm-g-GG) has been reported by Vijan et al [29]. In this study, different AAm-g-GG were synthesized by microwave-assisted free radical polymerization using cerric ammonium nitrate (CAN) as a redox initiator, and by means of varying the amount of acrylamide, CAN and microwave irradiation time.…”

Section: Gellan Gum Derivativesmentioning

confidence: 96%

Gellan Gum‐based Hydrogels for Tissue Engineering Applications

Silva‐Correia

Oliveira

Reis

2016

Biomaterials From Nature for Advanced Devices and Therapies

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“…The maximum detachment force or bioadhesive strength, i.e. the force required for separating the sample from the tissue surface was obtained 17 . Each measurement was repeated three times.…”

Section: Ex Vivo Mucoadhesive Strengthmentioning

confidence: 99%

Untitled

2016

IJPSR

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ABSTRACT:The objective of the present study was to prepare gum Cordia myxag-polyacrylonitrile using microwave irradiation and to evaluate its mucoadhesive applications. The graft co-polymerization of poly(acrylonitrile) on gum Cordia myxa was carried out employing 3-level 4-factor central composite experimental design. It was observed that the concentrations of ammonium persulphate and concentrations of acrylonitrile exerted a significant synergistic and antagonistic influence on grafting efficiency and percent swelling respectively. Graft co-polymer was characterized by fourier transform infrared spectroscopy, X-ray diffraction and differential scanning calorimeter. Mucoadhesive properties of the graft-copolymer were evaluated by formulating tablets employing captopril as the model drug. On comparative evaluation the gastroretentive tablets of captopril formulated using graft co-polymer (20%) showed ex vivo mucoadhesive time of 12 h whereas the tablets formulated using native Cordia myxa gum and carbopol 934 showed ex vivo mucoadhesive time of 6 h and 8 h respectively. According to the results obtained it was concluded that grafting of poly(acrylonitrile) on gum Cordia myxa enhances its mucoadhesion and thus, the grafted Cordia myxa gum seems to be promising excipient for the development of mucoadhesive drug delivery systems.

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Microwave assisted synthesis and characterization of acrylamide grafted gellan, application in drug delivery

Cited by 139 publications

References 21 publications

Cytotoxicity and Acute Gastrointestinal Toxicity of Bacterial Cellulose-Poly (acrylamide-sodium acrylate) Hydrogel: A Carrier for Oral Drug Delivery

Cytotoxicity and Acute Gastrointestinal Toxicity of Bacterial Cellulose-Poly (acrylamide-sodium acrylate) Hydrogel: A Carrier for Oral Drug Delivery

Gellan Gum‐based Hydrogels for Tissue Engineering Applications

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