Gellan Gum‐based Hydrogels for Tissue Engineering Applications

Silva‐Correia, Joana; Oliveira, Joaquím M.; Reis, Rui L.

doi:10.1002/9781119126218.ch19

Cited by 7 publications

(2 citation statements)

References 69 publications

(76 reference statements)

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“…The storage modulus after the occurrence of gelation of the hydrogels decreased with the increase in DBP content, which coincides with the compression test (Figure ). Improving the mechanical property remains a consideration, and it can be supplemented by applying cationic or photo-cross-linking to the GG matrix …”

Section: Resultsmentioning

confidence: 99%

Characterization and Potential of a Bilayered Hydrogel of Gellan Gum and Demineralized Bone Particles for Osteochondral Tissue Engineering

Choi

Kim

Rim

et al. 2020

ACS Appl. Mater. Interfaces

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Osteochondral (OC) tissue engineering (TE) is a promising strategy to regenerate acute or degenerative chondral and OC lesions. However, advancing a proper model for OC TE is still under way. Herein, a bilayer hydrogel (BH) based on gellan gum (GG) hydrogel and demineralized bone particles (DBPs) is suggested as a new model. The BH composite can be fabricated easily with a cell-friendly biomaterial and cross-linker. The BH composite was characterized by a morphological method and physicochemical aspect. The mechanical and rheological characters were further confirmed to verify its applicability in OC TE. The thermodynamic property of the composite was determined to analyze thermal stability and interaction among matrices. The bioactivity of the material was studied by treating simulated body fluid (SBF) solution for 28 days to examine the formation of crystalline structure in the BH construct. In vitro studies were carried out to study the viability and biochemical characters of the developed biomaterial. An in vivo study was performed to analyze the biocompatibility of the material and regeneration of the injured OC region implanted with BH composites. The data displayed stable physicochemical properties and mechanical characters when the DBPs were incorporated with a proper amount. The bioactivity of the DBP-loaded hydrogels displayed a high amount of apatite formation. The cytotoxicity of the fabricated material was low, which allows application in vitro and in vivo. The biochemical studies displayed a high level of alkaline phosphatase (ALP) activity and gene expression, which shows promising application of DBP-loaded GG in the bone layer of the BH model. The long-term in vivo study displayed excellent biocompatibility and great potential in the OC defected region. Overall, these results suggest the significance of combined and innovative approaches to improve the therapeutic strategies for OC regeneration, and the BH model suggested in this study can be a promising biomaterial model for OC TE.

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Section: Resultsmentioning

confidence: 99%

Characterization and Potential of a Bilayered Hydrogel of Gellan Gum and Demineralized Bone Particles for Osteochondral Tissue Engineering

Choi

Kim

Rim

et al. 2020

ACS Appl. Mater. Interfaces

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“…Использование геллана в биотехнологии, медицине, фармации и биоинженерии (в тканевой инженерии) подробно описано в обзорах [1][2][3][4][5][6][7]. Геллан представляет собой линейный анионный гетерополисахарид, получаемый из биомассы аэробной ферментацией микроорганизмом Sphingomonas elodea [8].…”

Section: Introductionunclassified

Mucoadhesive Properties of Gellan and Its Modified Derivatives

Tatykhanova

Aseyev

Kudaibergenov

2020

rev. and adv. in chem.

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Scaffold Fabrication Technologies and Structure/Function Properties in Bone Tissue Engineering

Collins

Ren

Young

et al. 2021

Adv Funct Materials

423

204

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Bone tissue engineering (BTE) is a rapidly growing field aiming to create a biofunctional tissue that can integrate and degrade in vivo to treat diseased or damaged tissue. It has become evident that scaffold fabrication techniques are very important in dictating the final structural, mechanical properties, and biological response of the implanted biomaterials. A comprehensive review of the current accomplishments on scaffold fabrication techniques, their structure, and function properties for BTE is provided herein. Different types of biomaterials ranging from inorganic biomaterials to natural and synthetic polymers and related composites for scaffold processing are presented. Emergent scaffolding techniques such as electrospinning, freeze-drying, bioprinting, and decellularization are also discussed. Strategies to improve vascularization potential and immunomodulation, which is considered a grand challenge in BTE scaffolding, are also presented.

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Gellan Gum‐based Hydrogels for Tissue Engineering Applications

Cited by 7 publications

References 69 publications

Characterization and Potential of a Bilayered Hydrogel of Gellan Gum and Demineralized Bone Particles for Osteochondral Tissue Engineering

Characterization and Potential of a Bilayered Hydrogel of Gellan Gum and Demineralized Bone Particles for Osteochondral Tissue Engineering

Mucoadhesive Properties of Gellan and Its Modified Derivatives

Scaffold Fabrication Technologies and Structure/Function Properties in Bone Tissue Engineering

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