Microwave-Assisted Syntheses of 2-Phenylbenzothiazoles

Synthesis of 4- or 6-(3-Benzyl-2,3-Dihydrobenzo[d]Thiazol-2-yl)Phenol Derivatives by a Novel Three-Component Reaction

“…They are also widely used for the synthesis of some organic photoelectric materials, such as liquid crystal materials, non-linear optical materials, heat-resistant fibres, whitening agents and the metal complexes used in organic light-emitting diodes. [7][8][9][10][11] Furthermore, they have also found potent utility as imaging agents for β-amyloid and as luminescent/ fluorescent agents. 12 Here we report the results of studies involving the reactions of benzothiazole and 2,6-dimethylbenzothiazole with benzyl bromide in the presence of some phenol derivatives, which constitute syntheses of 4-or 6-(3-benzyl-2,3-dihydrobenzo[d] thiazol-2-yl)phenol derivatives 4a-f by a novel three-component reaction (see Scheme 1 and Table 1).…”

A Novel Three-Component Reaction Involving Benzothiazole, Dialkyl Acethylenedicarboxylate and 1,3-Dicarbonyl Compounds or Anthrone

“…[3][4][5] Compounds with benzothiazole skeletons are of paramount interest because of their antitumour, anticancer, and antibacterial activities. [6][7][8][9][10] In addition, the benzothiazole nucleus is a key element in some thermally stable rigid-rod polymers, possessing high tensile strength and modulus. 11 N-Heterocycles are known to form zwitterions with activated acetylenes such as dimethyl acetylenedicarboxylate.…”

Recent advances in the synthesis of 2-substituted benzothiazoles: a review

“…Pal et al have found a new and easy protocol for the preparation of 2-phenylbenzothiazole from benzanilide by direct thiation under microwave irradiation (MWI) in the presence of catalytic amounts of iodine (I 2 ), which afforded moderate to good yields (Scheme 58, Method 1a and b). 160 This reaction was carried out in various solvents and also under solvent-free conditions but the best result was obtained using dimethylformamide (DMF) as a solvent. This method is considered to be of wide synthetic utility because a variety of the benzoates of aromatic amines were employed with unsubstituted orthopositions in this protocol.…”