Microwave‐Assisted Solvent‐Free Friedlaender Synthesis of 1,8‐Naphthyridines Using Ammonium Acetate as Catalyst.

Abstract

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Green Synthesis, Cyclization and Biological Study of Novel Series of 1,8-Naphthyridines Using Friedlander Condensation

“…Later normal work-up 2,2,2-trifluoro-1-(2-methyl-1,8-naphthyridin-3-yl) ethanone (3a) (R = CH 3 ; R 1 = CF 3 ) was obtained in 82 % yield. To know the role of microwave synthesis in rate improvement for the Fridlander condensation reaction, parallel reaction were carried out in are flex oil-bath for 2.5 h at100-120 °C, where the reaction process took longer time for end giving the product in very poor yields [2,27] (Fig. 1).…”

Synthesis and Anticancer Potentials of 1,8-Naphthyridine Analogues: A Review of Literature

“…Acidic or basic catalyzed reaction of 2-aminonicotinaldehyde (28) with α-substituted methylene carbonyl compounds (29). Thisclassical Friedlander reaction requires harsh conditions and a longer reaction time [46].…”

Three-Component One-Pot Synthesis of Novel Benzo[b]1,8-naphthyridines Catalyzed by Bismuth(III) Chloride

“…Functionalized naphthyridines have found applications as pharmaceuticals, fungicides, bactericides, herbicides, and insecticides as well as useful synthetic blocks in the preparation of several alkaloids [3][4][5][6]. Many syntheses of naphthyridines are known, but due to their importance, the development of new synthetic approaches remains an active research area [7,8].…”