Synthesis and Anticancer Potentials of 1,8-Naphthyridine Analogues: A Review of Literature

Abstract

This review focuses on the potential of 1,8-Naphthyridine derivativesinchemotherapeuticcancer treatment and highlights significant recent progress in the synthetic development of 1,8-naphthyridines as antitumor agents. The present review provides the classical (Skraup, Doebner-Von-Miller, Gould-Jacob, Meth-Cohn, Friedlander, Pfitzinger, Knorr and Conard Limpach, Combes, Niementowski and Pictet-Spengler)and green approaches (metal free ionic liquid mediated reactions, microwave irradiation reactions) for 1,8-naphthyridines synthesis. Their derivatives which exert their anticancer activity via several mechanismslike apoptosis-inducing agents, cell cycle arrest, topoisomerase I and II inhibitors, tubulin polymerization inhibitors, protein kinase inhibitors, intercalation with DNA, angiogenesis inhibitors, Ras protein inhibitors and telomerase inhibitors, are highlighted with proper synthetic methods, SAR studies and molecular docking of these derivatives.

Synthesis, Antimicrobial Activities and Molecular Docking Studies of New N-Acylated Derivatives of 5-(2-Phenyl-1,8-naphthyridin-3-yl)-1,3,4-oxadiazol-2-amine

“…Therefore, new approaches that allows the great research and optimization of new medicinal, pharmaceutical and agrochemical applications of 1,8-naphthyridine skeleton. 1,8-Naphthyridine structural skeleton emphasis on broad range of pharmacological submissions such as antihistaminic [4], anticonvulsant [5], antibacterial [6], antimalarial [7], anti-allergic [8], antidepressant [9], antioxidant [10], gastric anti-secretory [11], antitubercular [12], antimicrobial [13,14], potential diuretic [15], anticancer [16], HIV-1 integrase inhibitors [17], Alzheimer's disease [18], anti-inflammatory [19], telomerase and kinase inhibitors [20]. 1,8-Naphthyridines also found use in photophysical properties and in the study of bioorganic and progressions [21].…”