Microwave assisted quaternized cyclodextrin grafted chitosan (QCD-g-CH) nanoparticles entrapping ciprofloxacin

Dhiman, Priya; Bhatia, Meenakshi

doi:10.1007/s10965-021-02535-9

Cited by 7 publications

(4 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dhiman and Bhatia [ 165 ] prepared quaternised CD-grafted chitosan (Qβ-CD-g-CH) NPs entrapping ciprofloxacin for the development of a sustained release system, as demonstrated during a 24 h study. Qβ-CD-g-CH-ciprofloxacin NPs showed a better inhibitory effect against E. coli and S. aureus than Qβ-CD-g-CH and chitosan alone.…”

Section: Modern Drug-delivery Systemsmentioning

confidence: 99%

Cyclodextrin Inclusion Complexes with Antibiotics and Antibacterial Agents as Drug-Delivery Systems—A Pharmaceutical Perspective

Boczar

Michalska

2022

Pharmaceutics

View full text Add to dashboard Cite

Cyclodextrins (CDs) are a family of cyclic oligosaccharides, consisting of a macrocyclic ring of glucose subunits linked by α-1,4 glycosidic bonds. The shape of CD molecules is similar to a truncated cone with a hydrophobic inner cavity and a hydrophilic surface, which allows the formation of inclusion complexes with various molecules. This review article summarises over 200 reports published by the end of 2021 that discuss the complexation of CDs with antibiotics and antibacterial agents, including beta-lactams, tetracyclines, quinolones, macrolides, aminoglycosides, glycopeptides, polypeptides, nitroimidazoles, and oxazolidinones. The review focuses on drug-delivery applications such as improving solubility, modifying the drug-release profile, slowing down the degradation of the drug, improving biological membrane permeability, and enhancing antimicrobial activity. In addition to simple drug/CD combinations, ternary systems with additional auxiliary substances have been described, as well as more sophisticated drug-delivery systems including nanosponges, nanofibres, nanoparticles, microparticles, liposomes, hydrogels, and macromolecules. Depending on the desired properties of the drug product, an accelerated or prolonged dissolution profile can be achieved when combining CD with antibiotics or antimicrobial agents.

show abstract

Section: Modern Drug-delivery Systemsmentioning

confidence: 99%

Cyclodextrin Inclusion Complexes with Antibiotics and Antibacterial Agents as Drug-Delivery Systems—A Pharmaceutical Perspective

Boczar

Michalska

2022

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…26 For instance, Bhatia et al prepared pH-responsive nanoparticles based on β-CD grafted chitosan (QCD-g-CH), which could entrap and deliver ciprofloxacin. 27 Our research group, Teng et al , recently reported a pH-responsive supramolecular nanoparticle (DPN-β-CD/SDBS) based on polyamine-modified cyclodextrin and sodium dodecylbenzene sulfonate, which showed potential for controllable release of metformin hydrochloride (Metf). 28 These results suggested that pH-responsive nanoparticles can maximize the therapeutic efficiency of hydrophobic anti-cancer drugs on target cells and minimize the damage to normal cells.…”

Section: Introductionmentioning

confidence: 99%

β-Cyclodextrin-based supramolecular nanoparticles: pH-sensitive nanocarriers for the sustained release of anti-tumor drugs

Yan²,

Jin

et al. 2022

New J. Chem.

View full text Add to dashboard Cite

show abstract

“…Numerous strategies to improve bioavailability of drugs with poor/low solubility include drug micronization in to amorphous form [1], complexation with hydrophilic carrier [2][3][4], solid dispersion [5,6], micellar solubilization [7], nanoparticle technology [8][9][10][11], self-emulsifying drug delivery systems [12][13][14], salt formation [15], liposomes [16], nanostructured lipid carriers (NLC) [17,18], prodrug [19] and formation of co-crystal [20][21][22][23][24][25] etc. However, there are disadvantages associated with these techniques like agglomeration, instability during storage, requirement of advanced/or sophisticated instruments, tacky product etc.…”

Section: Introductionmentioning

confidence: 99%

Formulation, Optimization, in Vitro and in Vivo Investigation of Ketoprofen - Fumaric Acid Co-crystal for the Solubility Enhancement of Ketoprofen

Bhatia¹,

Kumar²,

Verma³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

The present piece of research work is framed as improving the solubility of ketoprofen by forming co-crystal using fumaric acid as a coformer. Co-crystal of ketoprofen and fumaric acid were prepared by simple solvent assisted grinding. The independent variables i.e. drug and coformer were mixed in 1:1 molar ratio and dependent variables were assumed to be solubility and % drug release. Differential scanning calorimetry, fourier transform infrared spectroscopy, X-ray diffraction, nuclear magnetic resonance and scanning electron microscopy techniques were used to characterize the preparation of optimized batch of co-crystal and further, evaluated for in-vitro and in-vivo anti-inflammatory and analgesic activities. Based on results of solubility and dissolution rate studies the drug showed 4-5 fold improvement in both the properties on co-crystallisation. The values of Gibbs free energy are negative at all levels of carrier demonstrating spontaneity of drug solubilization process. The IC50 value of optimized batch of co-crystal formulation and pure drug was observed as 327.33 µg/ml and 556.11 µg/ml, respectively, demonstrating that co-crystal formulation possesses more percentage protection against protein denaturation than the drug ketoprofen. In-vivo (anti-inflammatory and analgesic) activities revealed that optimized batch of co-crystal formulation delivered a rapid pharmacological response in wistar rats and albino mice when compared with standard drug.

show abstract

Microwave assisted quaternized cyclodextrin grafted chitosan (QCD-g-CH) nanoparticles entrapping ciprofloxacin

Cited by 7 publications

References 44 publications

Cyclodextrin Inclusion Complexes with Antibiotics and Antibacterial Agents as Drug-Delivery Systems—A Pharmaceutical Perspective

Cyclodextrin Inclusion Complexes with Antibiotics and Antibacterial Agents as Drug-Delivery Systems—A Pharmaceutical Perspective

β-Cyclodextrin-based supramolecular nanoparticles: pH-sensitive nanocarriers for the sustained release of anti-tumor drugs

Formulation, Optimization, in Vitro and in Vivo Investigation of Ketoprofen - Fumaric Acid Co-crystal for the Solubility Enhancement of Ketoprofen

Contact Info

Product

Resources

About