Microwave-assisted one-pot synthesis of a, β-unsaturated amides under solvent-free conditions

Abstract

Under microwave-assisted solvent-free conditions a one-pot reaction of triphenylphosphine, an aldehyde and N, N-diethyl chloroacetamide in the presence of zinc dust affords , -unsaturated amides stereoselectively in good yield. In comparison with the conventional heating method, the reaction was finished within five minutes under microwave irradiation.

Zinc-Mediated Facile Synthesis of α,β-Unsaturated Primary Amides

“…11 However, in many cases these methods were of limited scope. The Wittig reaction 12 is one of the most important general methods for the construction of carbon-carbon double bonds, and as a part of our studies on developing new Wittig reactions, [13][14][15][16] we considered developing a general route to α,β-unsaturated primary amide via a Wittig method.…”