A novel approach for converting N-substituted acetylpyrroles and primary alcohols into N-substituted pyrrolyl chalcones in air with assistance of t-BuOK is reported, and several prominent flavor and bioactive molecules were...
A facile and efficient methodology for the synthesis of cinnamides has been achieved under metal‐ and additive‐free conditions. This method allows the efficient C–N cross‐coupling of diverse cinnamic acids with tetraalkylthiuram disulfides through a simply mixing operation in 1,2‐dichloroethane at 100 °C. The protocol provides a direct approach to cinnamides and is featured with readily available starting materials and broad substrate scope, which shows its practical synthetic value in organic synthesis.
A practical method to synthesize N-heteroaryl esters from N-heteroaryl methanols with acyl cyanides via C–C bond cleavage without using any transition metal is demonstrated here. The use of Na2CO3/15-crown-5 couple enables access to a series of N-heteroaryl esters in high efficiency. This protocol is operationally simple and highly environmentally benign producing only cyanides as byproducts.
Transition‐metal‐free, temperature‐controlled chemoselectivities of alkenylazaarenes and alkylazaarenes through t‐BuOK/18‐crown‐6 promoted functionalization reaction of methyl‐substituted N‐heteroarenes with primary alcohols has been established. Following the methodology, a variety of olefinated and alkylated N‐heteroarenes have been efficiently obtained. To understand the mechanism of the reactions, various control and kinetic experiments were carried out.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.