Microwave assisted methacrylation of Kappa carrageenan: A bioink for cartilage tissue engineering

İlhan, Gülnihal Tok; Irmak, Gülseren; Gümüşderelı́oğlu, Menemşe

doi:10.1016/j.ijbiomac.2020.08.241

Cited by 31 publications

(15 citation statements)

References 30 publications

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“…[275] Carrageenan hydrogel laden with chondrogenic cells. [72] Silk-based hydrogel loaded with platelet-rich plasma (PRP). [300] Gelatin methacryloyl-based hydrogels with chondroprogenitor cells, mesenchymal stromal cells and chondrocytes.…”

Section: Cartilage Tissuementioning

confidence: 99%

“…Carrageenan has shown several potential biological and pharmaceutical applications, such as controlled drug release due to favorable biocompatibility [ 369 , 370 , 371 ]. Other biomedical applications of carrageenan-based hydrogels include tissue engineering [ 372 ], skin regeneration [ 373 ], wound healing [ 374 ], cartilage scaffold [ 375 ] and the 3D bioprinting of cellularized structures [ 71 , 72 , 73 ]. Crucially, carrageenan-based bio-inks have been identified as being able to circumvent the existing limitations of bio-ink-based bioprinting [ 71 ], such as the shear stress imposed on the cells and the poor ability of bio-inks to maintain complex tissue structures [ 71 ].…”

Section: Formulation and Use Of Natural Hydrogel-based Bio-inksmentioning

confidence: 99%

See 1 more Smart Citation

Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Fatimi

Okoro

Podstawczyk

et al. 2022

Gels

128

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Three-dimensional (3D) printing is well acknowledged to constitute an important technology in tissue engineering, largely due to the increasing global demand for organ replacement and tissue regeneration. In 3D bioprinting, which is a step ahead of 3D biomaterial printing, the ink employed is impregnated with cells, without compromising ink printability. This allows for immediate scaffold cellularization and generation of complex structures. The use of cell-laden inks or bio-inks provides the opportunity for enhanced cell differentiation for organ fabrication and regeneration. Recognizing the importance of such bio-inks, the current study comprehensively explores the state of the art of the utilization of bio-inks based on natural polymers (biopolymers), such as cellulose, agarose, alginate, decellularized matrix, in 3D bioprinting. Discussions regarding progress in bioprinting, techniques and approaches employed in the bioprinting of natural polymers, and limitations and prospects concerning future trends in human-scale tissue and organ fabrication are also presented.

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Section: Cartilage Tissuementioning

confidence: 99%

Section: Formulation and Use Of Natural Hydrogel-based Bio-inksmentioning

confidence: 99%

Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Fatimi

Okoro

Podstawczyk

et al. 2022

Gels

128

View full text Add to dashboard Cite

show abstract

“…Finally, the cell viability of the 3D printed composite scaffolds was evaluated using live/dead staining and confocal fluorescence imaging. Ilhan et al [ 95 ] aimed at obtaining a stable k-CAR hydrogel bioink for CTE. To this aim, the authors reported a methacrylation process using microwave energy.…”

Section: Naturally-derived Bioinks For 3d Bioprinting Of Cartilage Ti...mentioning

confidence: 99%

Three-Dimensional Bioprinting for Cartilage Tissue Engineering: Insights into Naturally-Derived Bioinks from Land and Marine Sources

Szychlinska

Bucchieri

Fucarino

et al. 2022

JFB

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In regenerative medicine and tissue engineering, the possibility to: (I) customize the shape and size of scaffolds, (II) develop highly mimicked tissues with a precise digital control, (III) manufacture complex structures and (IV) reduce the wastes related to the production process, are the main advantages of additive manufacturing technologies such as three-dimensional (3D) bioprinting. Specifically, this technique, which uses suitable hydrogel-based bioinks, enriched with cells and/or growth factors, has received significant consideration, especially in cartilage tissue engineering (CTE). In this field of interest, it may allow mimicking the complex native zonal hyaline cartilage organization by further enhancing its biological cues. However, there are still some limitations that need to be overcome before 3D bioprinting may be globally used for scaffolds’ development and their clinical translation. One of them is represented by the poor availability of appropriate, biocompatible and eco-friendly biomaterials, which should present a series of specific requirements to be used and transformed into a proper bioink for CTE. In this scenario, considering that, nowadays, the environmental decline is of the highest concerns worldwide, exploring naturally-derived hydrogels has attracted outstanding attention throughout the scientific community. For this reason, a comprehensive review of the naturally-derived hydrogels, commonly employed as bioinks in CTE, was carried out. In particular, the current state of art regarding eco-friendly and natural bioinks’ development for CTE was explored. Overall, this paper gives an overview of 3D bioprinting for CTE to guide future research towards the development of more reliable, customized, eco-friendly and innovative strategies for CTE.

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“…Table 1 summarizes the various functionalization of the carrageenan backbone using various types of monomers for different biomedical applications. Between them, the methacrylation of carrageenan, and the synthesis of methacrylate κ-carrageenan (KaMA), has attracted wide attention in the recent years [ 10 , 11 , 13 , 14 , 49 , 50 ]. According to Figure 1 A, by substituting the hydroxyl groups on κ-carrageenan with methacrylate groups, the methacrylation process occurred.…”

Section: Chemical Modification Of Carrageenanmentioning

confidence: 99%

“…Carrageenan-based hydrogels have also recently been applied for soft TE. For instance, İlhan et al [ 49 ] used a microwave-methacrylated κ-carrageenan hydrogel as a bioink for cartilage regeneration. They demonstrated that the utilization of microwave energy made the methacrylation process more efficient and increased the number of crosslinking sites available, leading to the boosted chemical photocrosslinking reactions.…”

Section: Hybrid Carrageenan-based Platforms and Its Applicationmentioning

confidence: 99%

Recent Advances in Chemically-Modified and Hybrid Carrageenan-Based Platforms for Drug Delivery, Wound Healing, and Tissue Engineering

et al. 2021

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Recently, many studies have focused on carrageenan-based hydrogels for biomedical applications thanks to their intrinsic properties, including biodegradability, biocompatibility, resembling native glycosaminoglycans, antioxidants, antitumor, immunomodulatory, and anticoagulant properties. They can easily change to three-dimensional hydrogels using a simple ionic crosslinking process. However, there are some limitations, including the uncontrollable exchange of ions and the formation of a brittle hydrogel, which can be overcome via simple chemical modifications of polymer networks to form chemically crosslinked hydrogels with significant mechanical properties and a controlled degradation rate. Additionally, the incorporation of various types of nanoparticles and polymer networks into carrageenan hydrogels has resulted in the formation of hybrid platforms with significant mechanical, chemical and biological properties, making them suitable biomaterials for drug delivery (DD), tissue engineering (TE), and wound healing applications. Herein, we aim to overview the recent advances in various chemical modification approaches and hybrid carrageenan-based platforms for tissue engineering and drug delivery applications.

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Microwave assisted methacrylation of Kappa carrageenan: A bioink for cartilage tissue engineering

Cited by 31 publications

References 30 publications

Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Three-Dimensional Bioprinting for Cartilage Tissue Engineering: Insights into Naturally-Derived Bioinks from Land and Marine Sources

Recent Advances in Chemically-Modified and Hybrid Carrageenan-Based Platforms for Drug Delivery, Wound Healing, and Tissue Engineering

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