Microwave assisted, Ca(II)-catalyzed Ritter reaction for the green synthesis of amides

Key Green Chemistry research areas from a pharmaceutical manufacturers’ perspective revisited

“…nitrile) has also been reported. 41 Ritter reactions have been performed in flow mode. 42 Nature has been using enzymes to create amide bonds efficiently and sustainably for eons.…”

Synthesis of Amido Esters and Amido Phosphonates through Carbonylation of Diazo Compounds Followed by Nucleophilic Addition Reaction

“…[7][8][9][10] Because of its importance, several synthetic methods have been developed to prepare different types of amides, most of which start from carbonyl compounds and amines. [14][15][16][17] These known methods, however, are not fully suitable to the synthesis of amido esters and amido phosphonates because of their low functional-group tolerance. [14][15][16][17] These known methods, however, are not fully suitable to the synthesis of amido esters and amido phosphonates because of their low functional-group tolerance.…”

“…[11][12][13] Widely used methods include: (i) carbonylation followed by amidation and (ii) the hydroamidation of alkynes and nitriles. [14][15][16][17] These known methods, however, are not fully suitable to the synthesis of amido esters and amido phosphonates because of their low functional-group tolerance. [11,15] Under certain reaction conditions, the Ritter reaction, the reaction of isonitriles and compounds with active methylene groups, and an amino carbonylation strategy can be employed for the synthesis of amido esters.…”

Mechanochemical Ritter Reaction: A Rapid Approach to Functionalized Amides at Room Temperature

“…On the other hand, attempts to perform the reaction under mild conditions, thus making it more environmentally friendly, were met with limited success. Shorter reaction times were achieved by utilizing FeCl 3 7c and Ca(OTf) 2 7e catalysts, although high temperatures were still required. A fast protocol at room temperature with an excess of sulfuric acid was established,8 however, the reaction was substrate‐specific for tert ‐butyl acetate as carbocation precursor.…”