Microwave‐Assisted Biosynthesis of CuO Nanoparticles Using Atalantia monophylla (L.) Leaf Extract and its Biomedical Applications

Abstract

The facile and rapid biosynthesis of copper oxide nanoparticles (AM-CuONPs) using Atalantia monophylla leaves extract under microwave irradiation is investigated. Optical and structural characterizations confirm the synthesis of spherical to rod-shaped phase pure AM-CuONPs. The antibacterial activity of AM-CuONPs is higher with Gram-positive bacteria compared to Gram-negative bacteria. The antioxidant potential of AM-CuONPs is reflected in radical scavenging activities in a concentration-dependent manner, tested by 2,2-diphenyl-1picrylhydrazyl and 3-ethylenebenzothiazoline-6-sulfonic acid diammonium salt assay. The promising anticancer activity of AM-CuONPs is observed by killing 80 % of HeLa cells without affecting normal human embryonic kidney cells. The results reveal the potential of biosynthesized AM-CuONPs for antibacterial, antioxidant, and anticancer applications.

Illuminating new possibilities: Effects of copper oxide nanoparticles on gastrointestinal adenocarcinoma cells in hypoxic condition

“…Similarly, biosynthesized CuONPs had good cytotoxicity against human breast and lung carcinoma cells with a minimum toxic effect on normal mouse fibroblasts [ 21 ]. In another attempt, promising anticancer activity of CuONPs was observed by affecting human cervical cancer cells without toxicity on human embryonic kidney cells [ 22 ]. Discriminative cytotoxic effects of biogenic CuONPs have been reported on human breast carcinoma cells compared with human foreskin fibroblasts [ 23 ].…”

Copper(II) Oxide Nanoparticles Embedded within a PEDOT Matrix for Hydrogen Peroxide Electrochemical Sensing

“…1.2 eV) and high reactivity in electrocatalytic reactions (one–two electron pathway) at low potential toward clinically relevant analytes such as glucose, uric acid, dopamine, and ascorbic acid [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. By taking advantage of soft chemistry approaches, such as hydro-/solvothermal methods [ 21 , 22 , 23 , 24 , 25 ], microwave procedures [ 26 , 27 , 28 ], and/or polyol-assisted synthesis [ 2 , 29 , 30 , 31 , 32 ], nanoscaled CuOs with diverse morphologies (nano-spheres, nanowires [ 7 , 33 ], rectangular-shaped nanobat- [ 22 ], urchin- [ 24 , 26 ], flake-, leaf- or flower-like [ 28 ] structures) were obtained. Moreover, copper(II) oxide materials exhibit high specific surface areas and/or hierarchically structures [ 34 ] that strongly influence the physicochemical properties and, further, the electrocatalytic activity.…”