Microvascular flow and tissue oxygenation after major abdominal surgery: association with post-operative complications

Jhanji, Shaman; Lee, Clement; Watson, David; Hinds, C. J.; Pearse, Rupert M

doi:10.1007/s00134-008-1325-z

Cited by 183 publications

(128 citation statements)

References 34 publications

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“…SOFA score is common for septic patients but lots of authors use it for scoring of MOF in trauma patients over time (10,11). SOFA score quantifi es and describes the evolution of organ dysfunction over time (12,13), and has been validated in trauma patients.…”

Section: Discussionmentioning

confidence: 99%

Normalization of blood lactate as early end-point of polytrauma treatment

Galkova¹,

Vrabelova²

2013

BLL

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Background:The main aim of the early treatment of polytrauma is recovery of patient's physiological functions. The early achievement of therapeutic goals, mainly adequate tissue perfusion and repayment of oxygen debt, are postulated. The aim of the study was to confi rm whether blood lactate level as a quantifi er of oxygen defi cit, as well as normalization of blood lactate level within the fi rst 24 hours, have an impact on the mortality and morbidity of seriously injured patients. Methods: Sixty-nine mechanically ventilated patients with a severe trauma and organ dysfunction defi ned according to SOFA score and ISS >17, age >15 years, were enrolled into this retrospective study. 8 patients died within fi rst 24 hours, 8 patients did not reach serum lactate level above 2 mmol/l on admission to hospital. The hypothesis that normalization of serum lactate level within 24 hours is related to lower mortality and morbidity, was assessed. Reduced mortality and morbidity were represented by lower severity of multi-organ dysfunction, the highest SOFA score during hospitalization, lower incidence of sepsis, number of days in ICU and artifi cial ventilation. Results:The association between severity of multi-organ failure (p=0.0006), mortality (p=0.0022) and repayment of oxygen debt was confi rmed. Hypothesis of sepsis incidence was not confi rmed (p=0.34). The association between number of days on artifi cial ventilation and number of days in ICU to repayment of oxygen debt was not confi rmed either. Multivariate signifi cant factors were age, GCS, ISS and SOFA score on patient's admission. Conclusion: The patients, who repaid oxygen debt within fi rst 24 hours, have lower morbidity and mortality (Tab. 6, Ref. 19). Full Text in PDF www.elis.sk.

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Section: Discussionmentioning

confidence: 99%

Normalization of blood lactate as early end-point of polytrauma treatment

Galkova¹,

Vrabelova²

2013

BLL

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“…O desbalanço entre oferta e consumo de oxigênio tecidual ocorre particularmente no intraoperatório e nas primeiras horas após o término da cirurgia. A redução da oferta de oxigênio nesse contexto está associada à redução da oxigenação global, hipoperfusão tecidual e a maior ocorrência de complicações pós-operatórias [274][275][276][277][278][279][280] .…”

Section: ) Monitorização Hemodinâmicaunclassified

I Diretriz Brasileira de Cardio-Oncologia da Sociedade Brasileira de Cardiologia

Filho¹,

Hajjar²,

Bacal³

et al. 2011

Arq. Bras. Cardiol.

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“…The reduction of oxygen supply in this context is associated with lower overall oxygenation, tissue hypoperfusion, and a higher rate of postoperative complications. Aiming to adjust the supply of tissue oxygen in the perioperative period, some recommendations should be followed [244][245][246][247][248][249][250] :…”

Section: Supply and Consumption Of Tissue Oxygenmentioning

confidence: 99%