Microvascular density and vascular endothelial growth factor immunoreactivity as predictors of regional lymph node metastasis from betel-associated oral squamous cell carcinoma

Wong, Yong–Kie; Liu, Chung-Ji; Kwan, Po-Cheung; Chao, Shou-Yee

doi:10.1016/s0278-2391(03)00725-0

Cited by 21 publications

(13 citation statements)

References 20 publications

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“…These findings agreed with the results of the previous studies that increase in VEGF expression was related to the poor prognosis [24,25] and local recurrence [26] for patients with oral cancer. This finding was also consistent with that of another study on betelassociated oral squamous cell carcinoma [27]. However, the report of Wong et al did not show the correlation of high expression of VEGF with disease-free survival.…”

Section: Discussionsupporting

confidence: 91%

High expressions of CD105 and VEGF in early oral cancer predict potential cervical metastasis

Chien

Hwang

et al. 2006

Journal of Surgical Oncology

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Section: Discussionsupporting

confidence: 91%

High expressions of CD105 and VEGF in early oral cancer predict potential cervical metastasis

Chien

Hwang

et al. 2006

Journal of Surgical Oncology

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“…Also as concerns this parameter, literature data are controversial. In fact, some studies have found any correlation between VEGF expression and angiogenesis in oral dysplasia or carcinoma [6,[19][20][21][22]. while other reports have clearly demonstrated this correlation [5,9,11,12,16,[23][24][25].…”

Section: Discussionmentioning

confidence: 99%

VEGF expression and angiogenesis in oral squamous cell carcinoma: an immunohistochemical and morphometric study

et al. 2010

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Angiogenesis is involved in tumor progression of oral squamous cell carcinoma (OSCC). In this study, we have investigated by immunohistochemistry vascular endothelial growth factor (VEGF) expression in tumor cells and we have correlated VEGF expression to microvessel area, evaluated by using CD105 as a marker of endothelial cells, in bioptic specimens of 54 human OSCC. Results demonstrated that VEGF is highly expressed in OSCC tumor specimens when compared to pre-neoplastic and normal tissues, without differences between the edge and inside the tumor. Moreover, VEGF expression is reduced in poor differentiated OSCC tumors when compared to moderate and good differentiated forms, and tumor microvessel area is higher in tumors when compared to pre-neoplastic lesions and normal tissues. Finally, VEGF and CD105 may be considered as reliable markers of tumor angiogenesis and progression in OSCC, even if we did not demonstrate any correlation between VEGF expression, tumor microvascular area, clinical stage, and lymph node status.

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“…Because the prognostic significance of these parameters is limited [10], many histopathological markers have been investigated in the recent decades: some are of little value in prognostication and others show more consistent associations [11]. Several examples may be mentioned, such as tumor thickness [12], histological grading [13], apoptotic indices [14], DNA ploidy [15], microvascular density [16], [17] and vascular and perineural invasion [18].…”

Section: Introductionmentioning

confidence: 99%

Proteomic Approaches Identify Members of Cofilin Pathway Involved in Oral Tumorigenesis

et al. 2012

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The prediction of tumor behavior for patients with oral carcinomas remains a challenge for clinicians. The presence of lymph node metastasis is the most important prognostic factor but it is limited in predicting local relapse or survival. This highlights the need for identifying biomarkers that may effectively contribute to prediction of recurrence and tumor spread. In this study, we used one- and two-dimensional gel electrophoresis, mass spectrometry and immunodetection methods to analyze protein expression in oral squamous cell carcinomas. Using a refinement for classifying oral carcinomas in regard to prognosis, we analyzed small but lymph node metastasis-positive versus large, lymph node metastasis-negative tumors in order to contribute to the molecular characterization of subgroups with risk of dissemination. Specific protein patterns favoring metastasis were observed in the “more-aggressive” group defined by the present study. This group displayed upregulation of proteins involved in migration, adhesion, angiogenesis, cell cycle regulation, anti-apoptosis and epithelial to mesenchymal transition, whereas the “less-aggressive” group was engaged in keratinocyte differentiation, epidermis development, inflammation and immune response. Besides the identification of several proteins not yet described as deregulated in oral carcinomas, the present study demonstrated for the first time the role of cofilin-1 in modulating cell invasion in oral carcinomas.

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Microvascular density and vascular endothelial growth factor immunoreactivity as predictors of regional lymph node metastasis from betel-associated oral squamous cell carcinoma

Cited by 21 publications

References 20 publications

High expressions of CD105 and VEGF in early oral cancer predict potential cervical metastasis

High expressions of CD105 and VEGF in early oral cancer predict potential cervical metastasis

VEGF expression and angiogenesis in oral squamous cell carcinoma: an immunohistochemical and morphometric study

Proteomic Approaches Identify Members of Cofilin Pathway Involved in Oral Tumorigenesis

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