2003
DOI: 10.1016/s0278-2391(03)00725-0
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Microvascular density and vascular endothelial growth factor immunoreactivity as predictors of regional lymph node metastasis from betel-associated oral squamous cell carcinoma

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Cited by 21 publications
(13 citation statements)
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“…These findings agreed with the results of the previous studies that increase in VEGF expression was related to the poor prognosis [24,25] and local recurrence [26] for patients with oral cancer. This finding was also consistent with that of another study on betelassociated oral squamous cell carcinoma [27]. However, the report of Wong et al did not show the correlation of high expression of VEGF with disease-free survival.…”
Section: Discussionsupporting
confidence: 91%
“…These findings agreed with the results of the previous studies that increase in VEGF expression was related to the poor prognosis [24,25] and local recurrence [26] for patients with oral cancer. This finding was also consistent with that of another study on betelassociated oral squamous cell carcinoma [27]. However, the report of Wong et al did not show the correlation of high expression of VEGF with disease-free survival.…”
Section: Discussionsupporting
confidence: 91%
“…Also as concerns this parameter, literature data are controversial. In fact, some studies have found any correlation between VEGF expression and angiogenesis in oral dysplasia or carcinoma [6,[19][20][21][22]. while other reports have clearly demonstrated this correlation [5,9,11,12,16,[23][24][25].…”
Section: Discussionmentioning
confidence: 99%
“…Because the prognostic significance of these parameters is limited [10], many histopathological markers have been investigated in the recent decades: some are of little value in prognostication and others show more consistent associations [11]. Several examples may be mentioned, such as tumor thickness [12], histological grading [13], apoptotic indices [14], DNA ploidy [15], microvascular density [16], [17] and vascular and perineural invasion [18].…”
Section: Introductionmentioning
confidence: 99%