VEGF expression and angiogenesis in oral squamous cell carcinoma: an immunohistochemical and morphometric study

Mărgăritescu, Claudiu; Pirici, Daniel; Stîngă, A. C.; Simionescu, Cristiana; Raica, Marius; Mogoantă, Laurențiu; Stepan, Alex Emilian; Ribatti, Doménico

doi:10.1007/s10238-010-0095-4

Cited by 55 publications

(57 citation statements)

References 30 publications

(56 reference statements)

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“…001), but it was not related to age, sex, tumor size and grade (p>0.05). in line with previous studies (24)(25)(26)(27) and verified that CD105 is expressed more in tumoral tissues and may have a major role in tumor development. We also observed a positive relation between CD105 expression and lymph node metastasis.…”

Section: Resultssupporting

confidence: 79%

Metastasis-associated protein 1 expression in oral squamous cell carcinomas: correlation with metastasis and angiogenesis

Andisheh-Tadbir¹,

Najvani²,

Pardis³

et al. 2014

TJPATH

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Objective: Metastasis-associated protein 1 (MTa1) has been associated with poor prognosis in several carcinomas. recent investigation has found that in different tumors, MTa1 protein significantly correlates with tumor angiogenesis, suggesting that MTa1 may be a possible angiogenesis-promoting molecule in malignant tumors. Thus, the current study was performed to determine the role of MTa1 protein in the biological behavior of oral squamous cell carcinoma and its relation with tumor angiogenesis.Material and Method: in this study, 44 oral squamous cell carcinomas and 15 normal epitheliums were reviewed by ihC staining for MTa1 and CD105. Results:Frequency of MTa1 expression in SCCs was recorded as 97.7%, which was significantly higher than that of the control group (33.3%). Mean percentage of MTa1 expression in oral squamous cell carcinomas was 76.88 ± 25.33% which was significantly higher than that of the control group (22.81 ±10.83). Our data showed a correlation between MTa1 expression with lymph node metastasis, tumor size and, stage. Evaluation of the correlation between MTa1 protein expression and micro vessel density showed that high micro vessel density was detected more frequently in tumors with MTa1 protein overexpression than in those without overexpression.Conclusion: in the present study, high expression of the MTa1 protein was seen in oral squamous cell carcinoma, and was closely associated with tumor progression and increased tumor angiogenesis. The findings may indicate that MTa1 protein has clinical potentials as a useful indicator of progressive phenotype, a promising prognostic predictor to identify patients with poor prognosis and may be a potential novel therapeutic target of anti-angiogenesis for patients with oral squamous cell carcinoma.Key Words: MTa-1 protein, Squamous cell carcinoma, immunohistochemistry, Metastasis, head and neck neoplasms Bulgular: Skuamoz hücreli karsinomlarda MTa 1 ekspresyonu %97,7 iken kontrol grubunda bu oran %33,3 olup karsinomlarda belirgin olarak yüksek saptanmıştır. MTa1 ekspresyonunun oral skuamoz hücreli karsinomlarda ortalama yüzdesi 76,88±%25,33 olup, kontrol grubundan belirgin olarak yüksektir (22,81±10,83). Sonuçlarımız lenf nodu metastazı, tümör boyutu ve evre ile MTa1 ekspresyonu arasında ilişkiyi desteklemiştir. MTa1 protein ekspresyonu ve mikrodamar dansitesi ilişkisi araştırıldığında yüksek mikrodamar dansitesinin MTa1 overekspresyonu gösteren tümörlerde, overekspresyon göstermeyen tümörlere göre daha sık olduğu saptanmıştır.Sonuç: Çalışma, oral skuamöz hücreli karsinomlarda yüksek MTa1 protein ekspresyonunun görüldüğünü ve bu ekspresyonun tümör progresyonu ve artmış tümör anjiyogenezi ile yakın ilişkisini göster-miştir. Bulgular MTa1 proteinin tümörün progresiv fenotipinin saptanmasında kullanılabileceğini, kötü prognozu belirleyen prognostik bir belirteç olarak klinik potansiyeli olabileceğini göstermektedir ve ayrıca oral skuamöz hücreli karsinom hastalarında antianjiyogenezise yönelik hedef tedavilerinde kullanılabilme potansiyeline sa...

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Section: Resultssupporting

confidence: 79%

Metastasis-associated protein 1 expression in oral squamous cell carcinomas: correlation with metastasis and angiogenesis

Andisheh-Tadbir¹,

Najvani²,

Pardis³

et al. 2014

TJPATH

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“…Comparison of the mean area using the Bonferroni multiple comparison test showed significant differences between the AOSMF and WDSCC groups, but not among any of the other groups. Though no previous studies have compared OSMF and WDSCC, a few studies have demonstrated a significant increase of MVD in WDSCC relative to normal oral mucosa (21,22). …”

Section: Discussionmentioning

confidence: 99%

Morphometric analysis of the mucosal vasculature in oral submucous fibrosis and its comparison with oral squamous cell carcinoma

Murgod

Kale²,

Angadi³

et al. 2014

J Oral Sci

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“…Consistently, a recent study by Mărgăritescu et al had similar findings with VEGF expression being reduced in poorly differentiated oral squamous cell carcinoma compared to moderate and well differentiated forms. 36 Moreover, VEGF expression at the invading tumor front was 4-10 times higher than in the deep tumor areas and was significantly associated with poor prognosis, particularly within stage I endometrial disease. 37 Another study by Toyoki et al showed that VEGF and COX-2 expressions decreased with tumor dedifferentiation.…”

Section: Discussionmentioning

confidence: 95%

VEGF and COX-2 Expression in Endometrial Carcinoma

Erol¹,

Tokyol²,

Özdemir³

et al. 2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Angiogenesis is a major factor in the development of solid tumors, such as endometrial cancer. Vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) are important cytokines that stimulate angiogenesis in vivo. The aim of the current study was to determine VEGF and COX-2 expression in endometrial adenocarcinomas and to investigate the relationship between these parameters and clinicopathologic parameters. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: Sections obtained from paraffin-embedded tissues in archive material of 23 patients who were diagnosed with endometrial carcinoma were retrospectively evaluated. VEGF and COX-2 expression levels in tumor cells and surrounding stroma on the tumor samples were determined by immunohistochemistry. R Re es su ul lt ts s: : VEGF and COX-2 were expressed both in the cytoplasm of tumor cells and in the stromal cells, but in a lower degree. There was a significant positive correlation between VEGF expressions of cancer cells and the stroma (r= 0.705, p< 0.01). A negative correlation was found between histological grade of the tumor and VEGF expression of cancer cells (r= -0.622, p= 0.002). A negative correlation was determined between myometrial invasion of the tumor and COX-2 expression of cancer cells (r= -0.441, p= 0.035). C Co on nc cl lu us si io on n: : Both VEGF and COX-2 were expressed by both tumor cells and stromal cells in endometrial cancer. While VEGF expression showed a negative correlation with the tumor grade, COX-2 expression exhibited a negative correlation with the myometrial invasion of the tumor. No correlation was determined between their expressions and other clinicopathologic prognostic parameters.K Ke ey y W Wo or rd ds s: : Vascular endothelial growth factor A; cyclooxygenase-2; endometrial neoplasms; neovascularization, pathologic; immunohistochemistry Ö ÖZ ZE ET T A Am ma aç ç: : Anjiyogenez, endometriyal kanser gibi solid tümörlerin gelişiminde önemli bir faktördür. Vasküler endotelyal büyüme faktörü (VEGF) ve siklooksijenaz-2 (COX-2) in vivo ortamda anjiyogenezi uyaran önemli sitokinlerdir. Bu çalışmanın amacı, endometriyal adenokarsinomlarda VEGF ve COX-2 sunumlarının belirlenmesi ve bu parametrelerin klinikopatolojik parametrelerle ilişkisinin araştırılmasıdır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Endometriyal karsinom tanısı almış 23 hastaya ait arşiv materyalindeki parafine gömülü dokulardan alınan kesitler geriye dönük olarak değerlendirildi. Tümör örneklerinde tümör hücreleri ve çevreleyen stromal dokuda VEGF ve COX-2 sunum dü-zeyleri immünohistokimyasal olarak saptandı. B Bu ul lg gu ul la ar r: : VEGF ve COX-2'nin hem tümör hücrele-rinin sitoplazmasında hem de daha düşük derecede olmak üzere tümör stromasındaki hücrelerde sunulduğu görüldü. Kanser hücreleri ve stroma arasında VEGF sunumları açısından anlamlı bir pozitif ilişki vardı (r= 0,705, p< 0,01). Tümörün histolojik derecesi ve kanser hücrelerinin VEGF sunumu arasında negatif bir il...

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VEGF expression and angiogenesis in oral squamous cell carcinoma: an immunohistochemical and morphometric study

Cited by 55 publications

References 30 publications

Metastasis-associated protein 1 expression in oral squamous cell carcinomas: correlation with metastasis and angiogenesis

Metastasis-associated protein 1 expression in oral squamous cell carcinomas: correlation with metastasis and angiogenesis

Morphometric analysis of the mucosal vasculature in oral submucous fibrosis and its comparison with oral squamous cell carcinoma

VEGF and COX-2 Expression in Endometrial Carcinoma

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