Microvascular changes after conbercept therapy in central retinal vein occlusion analyzed by optical coherence tomography angiography

Deng, Yang; Zhong, Qing; Zhang, Ai-Qi; Cai, Xiao-Juan; Lu, Mingzhi; Zhang, Shaochong; Su, Lishi; Chen, Hui; Sun, Limei; Chen, Guan-Di; Zhong, Liting; Jin, Chenjin; Chi, Wei

doi:10.18240/ijo.2019.05.16

Cited by 14 publications

(7 citation statements)

References 22 publications

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“…Furthermore, OCTA can reveal the retinal vascular structure layer by layer, which provides micromesh information about structural damage ( 11 ). Combined with structural optical coherence tomography ( 12 ), OCTA enables a more comprehensive understanding of vascular abnormalities in some eye diseases, including diabetic retinopathy ( 13 ), glaucoma ( 14 , 15 ), age-related macular degeneration ( 16 ), retinal vein obstruction ( 17 , 18 ), and Vogt-Koyanagi-Harada disease ( 19 ).…”

Section: Introductionmentioning

confidence: 99%

Vascular Abnormalities in Peripapillary and Macular Regions of Behcet's Uveitis Patients Evaluated by Optical Coherence Tomography Angiography

Yan

Hou

et al. 2021

Front. Med.

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Purpose: To investigate the involvement of peripapillary zone vascular abnormalities in Behcet's uveitis (BU) and associated visual dysfunction. We evaluated the retinal and choroidal microvascular features in both macular and peripapillary areas of BU patients to identify vascular abnormalities contributing to reduced best-corrected visual acuity (BCVA) using optical coherence tomography angiography (OCTA).Methods: A prospective, observational study was conducted in 24 eyes of 13 patients with BU and 24 eyes of 15 healthy participants as controls. They received a standard eye examination and were recorded by OCTA measurements of macular and peripapillary areas. The vascular densities of superficial capillary plexus (SCP) and deep capillary plexus (DCP), choroidal flow area, radial peripapillary capillary network (RPCN) density, foveal avascular zone (FAZ) area and perimeter, full retinal thickness (FRT), and peripapillary retinal nerve fiber layer thickness (pRNFLT) were measured.Correlations among microvascular, structural, and functional changes were assessed.Results: Our findings uncovered that the vascular density was significantly reduced in the peripapillary zone of BU eyes compared to healthy eyes, especially in the inferior subfield of the RPCN. The vascular densities of SCP and DCP quadrants within the macular zone had no significant difference between BU and control groups except for DCP density of the nasal parafoveal quadrant. Both FAZ area and perimeter were greater but without statistical significance in the BU group. Compared to healthy eyes, the choriocapillaris flow area was smaller while the FRT and pRNFLT were greater in the BU group. Notably, there was a significant correlation between the reduction in RPCN vascular density and decreased BCVA in BU patients.Conclusion: Based on OCTA, vascular changes associated with BU are more prominent in the peripapillary zone than those in the macular zone. The vascular density of the RPCN could serve as a sensitive indicator to monitoring BU pathogenic progression and treatment response using a non-invasively method of OCTA.

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Section: Introductionmentioning

confidence: 99%

Vascular Abnormalities in Peripapillary and Macular Regions of Behcet's Uveitis Patients Evaluated by Optical Coherence Tomography Angiography

Yan

Hou

et al. 2021

Front. Med.

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“…The 1-month posttreatment logMAR BCVA was negatively associated with the choriocapillaris flow area in BRVO but not CRVO ( 82 , 83 ). One study ( 85 ) showed that in CRVO following ME resolution, the logMAR BCVA after intravitreal aflibercept treatment was negatively connected with retinal perfusion area for both the SCP and the DCP.…”

Section: Optical Coherence Tomography Angiographymentioning

confidence: 87%

“…At baseline, the BCVA was negatively associated with the choriocapillaris flow area, the whole en face (3 mm × 3 mm) vessel density (VD), and the overall parafoveal VD in both the super capillary plexus (SCP) and deep capillary plexus (DCP) in the BRVO, but not in CRVO ( 82 , 83 ). A cross-sectional study combining OCT and OCTA images showed a significant negative correlation between logMAR VA and FAVD/DFD [the fovea–AV crossing distance (FAVD), optic disc–fovea distance (DFD)] values, but no correlation between logMAR VA and the DAVD/DFD [optic disc-AV crossing distance (DAVD)] in patients with BRVO ( 84 ).…”

Section: Optical Coherence Tomography Angiographymentioning

confidence: 99%

Potential Prognostic Indicators for Patients With Retinal Vein Occlusion

et al. 2022

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The second most prevalent cause of retinal vascular disease is retinal vein occlusion (RVO). RVO raises intravascular pressure in the capillary and veins, triggering vessel barrier collapse and subsequent leaking of blood or plasma components into the tissue (edema). Macular edema (ME) is a major complication of RVO that results in significant visual impairment. Laser therapy, intravitreal steroid injections, and vascular endothelial growth factor (VEGF) inhibitors are the major therapeutic techniques. Different therapies reduce ME of RVO and improve visual activity. However, some people have no impact on the resolution of ME, while others have a poor visual prognosis despite full ME cure. There are many investigators who studied the relationship between indicators of various instruments with visual activity. However, a summary of those findings is currently lacking. Therefore, we will focus on the predictive factors of different studies associated with positive visual activity outcomes, which would be very useful and important to help address both treatment expectations and methods for patients with RVO.

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“…1 - 3 ME patients were largely administered with conbercept, a vascular endothelial growth factor (VEGF) inhibitor proven to produce desired therapeutic effect in treating neovascularization in fundus and relieve ME based on a multiple-dosing regimen. 4 - 6 …”

Section: Introductionmentioning

confidence: 99%

Clinical efficacy of conbercept plus micropulse laser (577 nm) treatment in macular edema secondary to non-ischemic central retinal vein occlusion

Li¹,

Ren²,

Sun³

et al. 2022

Pak J Med Sci

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Objectives: To observe the clinical efficacy and complications of conbercept combined with a 577-nm micropulse laser in patients with macular edema (ME) secondary to non-ischemic central retinal vein occlusion (CRVO). Methods: A total of 153 patients who were diagnosed with non-ischemic CRVO-induced ME and treated by Shijiazhuang People’s Hospital during January 2019 and January 2021 were included in this study. The patients were divided into a control group and an experimental group by choice of treatment. The control group was treated by conbercept alone, while the experimental group underwent laser treatment on this basis. The best corrected visual acuity (BCVA) was determined by the internationally standardized logarithm of the minimum angle of resolution (logMAR) chart and the central macular thickness (CMT) was measured by optical coherence tomography (OCT) before and at one and three months after treatment. Complications such as conjunctival hemorrhage and elevated intraocular pressure (if any) were recorded during the 3-month follow-up period. Results: Conbercept could improve the BCVA and CMT of patients with non-ischemic CRVO (P <0.05, respectively), and the combined use of conbercept with micropulse laser treatment yielded greater improvements in these measures compared with the pre-treatment condition (P <0.05, respectively); moreover, the differences between the control group and the experimental group were statistically significant (all P <0.05). The two groups had similar complication rates and did not record any serious adverse reactions. Conclusions: Conbercept combined with 577-nm micropulse laser treatment can benefit patients with non-ischemic CRVO-induced ME by improving their visual acuity and relieve ME symptoms. As a regimen of impressive clinical efficacy, it is of great value for wide application in clinical practice. doi: https://doi.org/10.12669/pjms.38.5.5231 How to cite this:Li L, Ren Q, Sun Z, Yu H. Clinical efficacy of conbercept plus micropulse laser (577 nm) treatment in macular edema secondary to non-ischemic central retinal vein occlusion. Pak J Med Sci. 2022;38(5):---------. doi: https://doi.org/10.12669/pjms.38.5.5231 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Microvascular changes after conbercept therapy in central retinal vein occlusion analyzed by optical coherence tomography angiography

Cited by 14 publications

References 22 publications

Vascular Abnormalities in Peripapillary and Macular Regions of Behcet's Uveitis Patients Evaluated by Optical Coherence Tomography Angiography

Vascular Abnormalities in Peripapillary and Macular Regions of Behcet's Uveitis Patients Evaluated by Optical Coherence Tomography Angiography

Potential Prognostic Indicators for Patients With Retinal Vein Occlusion

Clinical efficacy of conbercept plus micropulse laser (577 nm) treatment in macular edema secondary to non-ischemic central retinal vein occlusion

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