Microtubules in Biological Cells as Circular Waveguides and Resonators

Jelínek, F; Pokorný, J.

doi:10.1081/jbc-100103161

Cited by 17 publications

(18 citation statements)

References 5 publications

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“…Our macroscopic observations may be microscopically explained by the interaction between microwaves and the cytoskeleton network that represents both the origin of endogenous electromagnetic activity, in respect of Fröhlich's theory of coherent vibration states (Fröhlich, 1968), and the target for external irradiations (Jelinek and Pokorny, 2001;Pokorny, 1999), according to the frequency coupling theory of the temporal resonance (Illarionov, 1998) and to the electroacoustic transduction of the microspatial resonance theory (Bistolfi, 1998;Golant, 1994). The cytoskeleton has been proposed as a target for other kinds of exogenous irradiation in addition to microwaves: in particular, the microtubule cavities as individual components would selectively react to soft x-rays band, while the cytoskeleton as a whole system would respond to the far-infrared region (Jelinek and Pokorny, 2001;Pokorny, 1999).…”

Section: Discussionmentioning

confidence: 98%

“…The cytoskeleton has been proposed as a target for other kinds of exogenous irradiation in addition to microwaves: in particular, the microtubule cavities as individual components would selectively react to soft x-rays band, while the cytoskeleton as a whole system would respond to the far-infrared region (Jelinek and Pokorny, 2001;Pokorny, 1999). Because these effective bands are too much higher or lower than the red/nearinfrared range, we could exclude that this component of our electromagnetic emission has acted on the cytoskeleton in the results we obtained.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Nonthermal Microwave Radiations Affect the Hypersensitive Response of Tobacco to Tobacco Mosaic Virus

Betti

Trebbi

Lazzarato

et al. 2004

The Journal of Alternative and Complementary Medicine

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Nonthermal Microwave Radiations Affect the Hypersensitive Response of Tobacco to Tobacco Mosaic Virus

Betti

Trebbi

Lazzarato

et al. 2004

The Journal of Alternative and Complementary Medicine

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“…A living cell forms a cavity resonator for electromagnetic waves at the frequency of about 10 13 Hz, which corresponds to a cell of a spherical shape with a diameter about 10 µm. 36 The positions of the mitotic spindle poles may correspond to the nodes of the cavity electromagnetic field and the geometrical shape of polar and kinetochore microtubules to the line of force of the field. 27 Dimensions of the inner microtubule cavity correspond to a soft X-ray resonator.…”

Section: Oscillations In Microtubulesmentioning

confidence: 99%

Cancer — Pathological Breakdown of Coherent Energy States

Pokorný

Kobilková

et al. 2014

Biophys. Rev. Lett.

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The fundamental property of biological systems is a coherent state far from thermodynamic equilibrium excited and sustained by energy supply. Mitochondria in eukaryotic cells produce energy and form conditions for excitation of oscillations in microtubules. Microtubule polar oscillations generate a coherent state far from thermodynamic equilibrium which makes possible cooperation of cells in the tissue. Mitochondrial dysfunction (the Warburg effect) in cancer development breaks down energy of the coherent state far from thermodynamic equilibrium and excludes the afflicted cell from the ordered multicellular tissue system. Cancer lowering of energy and coherence of the state far from thermodynamic equilibrium is the biggest difference from the healthy cells. Cancer treatment should target mitochondrial dysfunction to restore the coherent state far from thermodynamic equilibrium, apoptotic pathway, and subordination of the cell in the tissue. A vast variety of genetic changes and other disturbances in different cancers can result in several triggers of mitochondrial dysfunction. In cancers with the Warburg effect, mitochondrial dysfunction can be treated by inhibition of four isoforms of pyruvate dehydrogenase kinases. Treatment of the reverse Warburg effect cancers would be more complicated. Disturbances of cellular electromagnetic activity by conducting and asbestos fibers present a special problem of treatment.

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“…One of the most important structures involving microtubules is the mitotic spindle in dividing cell (29). The microtubules are an extremely dynamic structure whose functioning depends on dynamic instability induced by internal electromagnetic forces (30). It seems that signifi cantly lower proliferation of cells exposed for three hours, found on the third postirradiation day, is a consequence of the microtubule structure damage observed immediately after RF/MW irradiation.…”

Section: Figure 3 Mitotic Index In V79 Cells Exposed To Rf/mw Radiatimentioning

confidence: 99%

Disturbance of Cell Proliferation in Response to Mobile Phone Frequency Radiation

Trošić

Pavičić

2009

Archives of Industrial Hygiene and Toxicology

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The aim of study was to determine the infl uence of mobile phone frequency radiation on the proliferation, cytoskeleton structure, and mitotic index of V79 cells after 1 h, 2 h, and 3 h of exposure. V79 cells were cultured in standard laboratory conditions and exposed to continuous-wave (CW) RF/MW radiation of 935 MHz, electric fi eld strength of (8.2±0.3) V m -1 , and specifi c absorption rate (SAR) of 0.12 W kg -1 . To identify proliferation kinetics, the cells were counted for each hour of exposure 24 h, 48 h, 72 h, and 96 h after respective exposures. Microtubule proteins were determined using specifi c immunocytochemical methods. Cell smears were analysed under a fl uorescent microscope. The study included negative and positive controls. Mitotic index was determined by estimating the number of dividing cells 24 h after exposure and dividing it with the total number of cells. In comparison to the controls, cell proliferation declined in cells exposed for three hours 72 h after irradiation (p<0.05). Microtubule structure was clearly altered immediately after three hours of irradiation (p<0.05). The mitotic index in RF/MW-exposed cells did not differ from negative controls. However, even if exposure did not affect the number of dividing cells, it may have slowed down cell division kinetics as a consequence of microtubule impairment immediately after exposure.

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Microtubules in Biological Cells as Circular Waveguides and Resonators

Cited by 17 publications

References 5 publications

Nonthermal Microwave Radiations Affect the Hypersensitive Response of Tobacco to Tobacco Mosaic Virus

Nonthermal Microwave Radiations Affect the Hypersensitive Response of Tobacco to Tobacco Mosaic Virus

Cancer — Pathological Breakdown of Coherent Energy States

Disturbance of Cell Proliferation in Response to Mobile Phone Frequency Radiation

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