Microtechnical Interfaces to Neurons

Meyer, J.-U.

doi:10.1007/3-540-69544-3_6

Cited by 25 publications

(11 citation statements)

References 63 publications

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“…Again in 1952, the group analytically described the mechanism of nerve excitation and the subsequent generation of action potentials [4, 5]. Over the past several years, neural electrodes or probes became a key tool to record the action potentials from neurons [6], stimulate specific brain regions [7-14], and ultimately understand the functioning of the brain. The stimulation and recording from a single neuron [15-17] or complex networks of neurons using multiple electrodes [18-22] in cortical and sensory areas in brain [23-25] help in understanding various neural characteristics such as population encoding [26, 27], somatosensory organization [28-30], nervous system behavior [31-33], and network connectivity [20].…”

Section: Introductionmentioning

confidence: 99%

“…A number of reviews have been previously published for neural probes and neuroMEMS by Najafi [12], Banks [48], Heiduschka and Thanos [13], Stieglitz and Meyer [14], and more recently, Donoghue [59], Wise [60] and Pearce and Justin [49]. In particular, these reviews describe generic methods to interface probes with neural tissue, neural probe design and structure, integration of probes with Integrated Circuit (ICs), and biocompatibility issues.…”

Section: Introductionmentioning

confidence: 99%

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NeuroMEMS: Neural Probe Microtechnologies

Hajj-Hassan

Chodavarapu

Musallam

2008

Sensors

168

114

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Neural probe technologies have already had a significant positive effect on our understanding of the brain by revealing the functioning of networks of biological neurons. Probes are implanted in different areas of the brain to record and/or stimulate specific sites in the brain. Neural probes are currently used in many clinical settings for diagnosis of brain diseases such as seizers, epilepsy, migraine, Alzheimer's, and dementia. We find these devices assisting paralyzed patients by allowing them to operate computers or robots using their neural activity. In recent years, probe technologies were assisted by rapid advancements in microfabrication and microelectronic technologies and thus are enabling highly functional and robust neural probes which are opening new and exciting avenues in neural sciences and brain machine interfaces. With a wide variety of probes that have been designed, fabricated, and tested to date, this review aims to provide an overview of the advances and recent progress in the microfabrication techniques of neural probes. In addition, we aim to highlight the challenges faced in developing and implementing ultra-long multi-site recording probes that are needed to monitor neural activity from deeper regions in the brain. Finally, we review techniques that can improve the biocompatibility of the neural probes to minimize the immune response and encourage neural growth around the electrodes for long term implantation studies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

NeuroMEMS: Neural Probe Microtechnologies

Hajj-Hassan

Chodavarapu

Musallam

2008

Sensors

168

114

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“…Today several instrumentation techniques enable the recording of electrical activities inside the cortex during in vivo experiments using arrays of diodes (Grinvald et al 1999;Stieglitz and Meyer 1999;Meyer et al 2000;Takahashi et al 2000). These techniques provide spatiotemporal data that are invaluable to the study of sensory information processing mechanisms inside the brain.…”

Section: Introductionmentioning

confidence: 98%

Parameter estimation in a model for multidimensional recording of neuronal data: a Gibbsian approximation approach

Abdallahi

Rota

Béguin

et al. 2003

Biological Cybernetics

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This article proposes improved numerical procedures for estimating parameters in a spatiotemporal lattice model introduced for the analysis of cortical activities monitored from arrays of diodes. The numerical algorithms are based on approximations inspired by statistical physics. Both Gibbsian and mean-field approximations are used; they allow for computing local conditional probabilities inside the lattice. The statistical procedures rely on the computation of pseudomaximum-likelihood estimators. The estimators are evaluated on the basis of Monte Carlo simulations. These simulations show that mean-field approximations are useful for reducing the variance of estimators when the data are recorded from arrays of 144 diodes (which are in accordance with standard practice). In light of these improved methods, we give new interpretations for a data set obtained from optical recording of a Guinea pig's auditory cortex in response to pure tone stimulations.

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“…Cell patterning technology broadly supports the development of bioelectronic devices by optimizing the location and close contact of cells vis a vis microelectrodes and by suppressing inflammatory responses of tissue. 172 For example, for the development of neural prostheses 173,174,175,176,177,178 cell patterning technology can be applied to an implanted electrode device to promote neurite outgrowth, to suppress glial cell proliferation, and to optimize signal transmission across the tissue-prosthesis interface. We review here only the in vitro use of electrically active cells on planar microelectrode arrays and the patterning of cells on those arrays.…”

Section: Introductionmentioning

confidence: 99%

Topographical and Physicochemical Modification of Material Surface to Enable Patterning of Living Cells

Jung¹,

Kapur²,

Adams³

et al. 2001

Critical Reviews in Biotechnology

170

100

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Precise control of the architecture of multiple cells in culture and in vivo via precise engineering of the material surface properties is described as cell patterning. Substrate patterning by control of the surface physicochemical and topographic features enables selective localization and phenotypic and genotypic control of living cells. In culture, control over spatial and temporal dynamics of cells and heterotypic interactions draws inspiration from in vivo embryogenesis and haptotaxis. Patterned arrays of single or multiple cell types in culture serve as model systems for exploration of cell-cell and cell-matrix interactions. More recently, the patterned arrays and assemblies of tissues have found practical applications in the fields of Biosensors and cell-based assays for Drug Discovery. Although the field of cell patterning has its origins early in this century, an improved understanding of cell-substrate interactions and the use of microfabrication techniques borrowed from the microelectronics industry have enabled significant recent progress. This review presents the important early discoveries and emphasizes results of recent state-of-the-art cell patterning methods. The review concludes by illustrating the growing impact of cell patterning in the areas of bioelectronic devices and cell-based assays for drug discovery.

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Microtechnical Interfaces to Neurons

Cited by 25 publications

References 63 publications

NeuroMEMS: Neural Probe Microtechnologies

NeuroMEMS: Neural Probe Microtechnologies

Parameter estimation in a model for multidimensional recording of neuronal data: a Gibbsian approximation approach

Topographical and Physicochemical Modification of Material Surface to Enable Patterning of Living Cells

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