Microstructured Multilevel Bacterial Cellulose Allows the Guided Growth of Neural Stem Cells

Geisel, Natalie; Clasohm, Jasmin; Shi, Xudian; Lamboni, Lallepak; Yang, Junchuan; Mattern, Kamil; Yang, Guang; Schäfer, Karl‐Herbert; Saumer, Monika

doi:10.1002/smll.201601679

Cited by 38 publications

(36 citation statements)

References 31 publications

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“…Regarding these properties, BC has merged as a promising material in this field. For example, Geisel et al . produced BC with controlled topographies through bacterial culturing and molding with patterns.…”

Section: Applicationsmentioning

confidence: 99%

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Carvalho

Guedes

Sousa

et al. 2019

Biotechnology Journal

120

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Bacterial cellulose (BC) is a nanocellulose form produced by some nonpathogenic bacteria. BC presents unique physical, chemical, and biological properties that make it a very versatile material and has found application in several fields, namely in food industry, cosmetics, and biomedicine. This review overviews the latest state‐of‐the‐art usage of BC on three important areas of the biomedical field, namely delivery systems, wound dressing and healing materials, and tissue engineering for regenerative medicine. BC will be reviewed as a promising biopolymer for the design and development of innovative materials for the mentioned applications. Overall, BC is shown to be an effective and versatile carrier for delivery systems, a safe and multicustomizable patch or graft for wound dressing and healing applications, and a material that can be further tuned to better adjust for each tissue engineering application, by using different methods.

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Section: Applicationsmentioning

confidence: 99%

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Carvalho

Guedes

Sousa

et al. 2019

Biotechnology Journal

120

View full text Add to dashboard Cite

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“…Micropatterned BC was bioprinted by the fermentation of A. xylinum using a slab of micropatterned polydimethylsiloxane (PDMS) as template (Figure b) . A high‐throughput micropattern screening PDMS chip was first fabricated to seek the optimal dimensions of the micropattern for parallel BC nanofiber formation.…”

Section: Resultsmentioning

confidence: 99%

“…Bacterial cellulose (BC) is an excellent material for biomedical applications due to its high porosity and mechanical resistance, excellent biocompatibility, and optical transparency . BC‐based wound dressings and artificial blood vessels with potential clinical applications were developed . Microfluidic techniques provide a convenient platform for cell or tissue manipulation from the micro to the macroscale.…”

Section: Introductionmentioning

confidence: 99%

“…Microfluidic techniques provide a convenient platform for cell or tissue manipulation from the micro to the macroscale. Using microfluidics, cells were patterned for cell biology research and built into hierarchically organized 3D tubular tissues for vascular tissue engineering . Based on previous work from this group, BC and microfluidics were combined herein to reversely construct a functional TE‐IVD.…”

Section: Introductionmentioning

confidence: 99%

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Reverse Reconstruction and Bioprinting of Bacterial Cellulose‐Based Functional Total Intervertebral Disc for Therapeutic Implantation

Yang

Wang

Zhang

et al. 2017

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The degradation of intervertebral discs (IVD), a typical hierarchical structured tissue, causes serious neck and back pain. The current methods cannot fully reconstitute the unique structure and function of native IVD. In this study, by reverse reconstruction of the structure of native IVD and bioprinting bacterial cellulose (BC) nanofibers with a high-throughput optimized micropattern screening microchip, a total IVD is created that contained type II collagen-based nucleus pulposus (NP) and hierarchically organized and micropatterned BC-based annulus fibrosus (AF), mimicking native IVD tissue. The artificial NP contains rat NP cells, whereas the AF contains concentrically arranged BC layers with aligned micropatterns and attached AF cells in +/-30° alternate directions between adjacent layers. Long-term (3 months) implantation experiments on rats demonstrate the excellent structural (shape maintenance, hydration, tissue integration) and functional (mechanical support and flexibility) performance of the artificial IVD. This study provides a novel strategy for creating highly sophisticated artificial tissues.

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“…The movement of G. xylinus on template was restricted by oxygen availability and by the groove pattern. BC films with grid and strip structures were also obtained through precise control of culture conditions [128,129]. In addition, genetic manipulation is a promising technique to achieve this goal.…”

Section: Microbial Cell Factories: Manufacturing Functional Metabolitesmentioning

confidence: 99%

Fabrication of nanocomposites and hybrid materials using microbial biotemplates

Shi

Ullah

et al. 2017

Adv Compos Hybrid Mater

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Microbes are important part of life that vary in sizes and shapes, diverse surface chemistry and biology, and porous nature of their cell walls. Besides their importance in industrial processes such as fermentation, these serve as biotemplates and provide a biomimetic approach for fabrication of multifarious complex constructs with predefined features, ordered composites and hybrid nanomaterials, microdevices, and micro/nanorobots through various strategies. The template or building blocks for such approaches can be bacterial, algal, and fungal cells or virus particles. Here, we have summarized recent advancements in biofabrication based on live microbes. Using engineering approaches and suitable methods, live microbes can be manipulated as functional Bmicro/nanodevices and -robots^to further perform biological functions such as replication, distribution, motility, formation of colonies, and secretion of metabolites at will. Biofabrication based on microbes provides effective methods to control and manipulate microbes as functional live building blocks to create micro/nanodevices and -robots for biomedical and energy applications.

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Microstructured Multilevel Bacterial Cellulose Allows the Guided Growth of Neural Stem Cells

Cited by 38 publications

References 31 publications

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Reverse Reconstruction and Bioprinting of Bacterial Cellulose‐Based Functional Total Intervertebral Disc for Therapeutic Implantation

Fabrication of nanocomposites and hybrid materials using microbial biotemplates

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