Fabrication of nanocomposites and hybrid materials using microbial biotemplates

Shi, Zhijun; Shi, Xudian; Ullah, Muhammad Wajid; Li, Sixiang; Ревин, В. В.; Yang, Guang

doi:10.1007/s42114-017-0018-x

Cited by 23 publications

(7 citation statements)

References 143 publications

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“…The unique structures of PNCs make them possess unique properties when compared to the pure polymers. Therefore, different researches have been conducted on Polymer nanocomposites [19][20][21][22][23][24][25], and these materials have been widely used in different fields, such as biological [26,27], electronics [28][29][30], electromagnetic [31] and aerospace.…”

Section: Introductionmentioning

confidence: 99%

Ballistic performance of Kevlar fabric impregnated with nanosilica/PEG shear thickening fluid

Khodadadi

Liaghat

Vahid

et al. 2019

Composites Part B: Engineering

134

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This study presents the response of fiber reinforced composite material composed of woven Kevlar fabric impregnated with a colloidal shear thickening fluid (STF) under high velocity impact loading. The STF was made by dispersing silica nanoparticles at 15, 25, 35 and 45 wt.% loading in polyethylene glycol. The effects of silica nanoparticle loading on energy absorption and ballistic limit were studied experimentally. Rheological results revealed that shear thickening occurred at all four nanosilica loading and higher loading showing the higher shear thickening at lower shear rate. SEM images confirmed good dispersion of nanosilica particles in the suspension. The results of the pull out test show that by increasing nanosilica loading, the force required to pull the yarn out from the fabric impregnated by STF increases. Impact resistance performance of Kevlar fabric is significantly enhanced due to the presence of STF. Although high velocity impact results show that by increasing nanosilica loading, the energy absorption of composites increases, but in high loading of nanosilica, the effectiveness of STF decreases. For further investigation, the energy absorption at the ballistic limit was normalized by the areal density of the neat and impregnated fabrics to give the specific energy absorption (SEA). It is found that the SEA of 15 wt.% nanosilica loading is lower compared to the neat fabric. Also the highest SEA turn out in the case of 35 wt.% STF/Kevlar composites in which the SEA is 2.3 times larger than those of the neat fabric.

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Section: Introductionmentioning

confidence: 99%

Ballistic performance of Kevlar fabric impregnated with nanosilica/PEG shear thickening fluid

Khodadadi

Liaghat

Vahid

et al. 2019

Composites Part B: Engineering

134

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“…Significant efforts have been made to develop or discover different types of amyloid inhibitors to prevent the aggregation of misfolded amyloid peptides, including small organic molecules (EGCG, − curcumin, , tanshinone, − Oleuropein), nanoparticles (AgNPs, CeONP@POMs, SeNPs, IDA-NP, GQD-T − ), peptide inhibitors (Aβ 16–20 , Aβ 17–21 , Aβ 31–42 , Aβ 39–42 , and their analogues − ), and polymers (poly(acrylic acid), poly(amidoamine) dendrimer, polyA-FF-ME). Most of these amyloid inhibitors only work for a specific amyloid peptide and show sequence-dependent inhibition capacity.…”

Section: Introductionmentioning

confidence: 99%

Genistein: A Dual Inhibitor of Both Amyloid β and Human Islet Amylin Peptides

Ren

Liu

Zhang

et al. 2018

ACS Chem. Neurosci.

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Abnormal misfolding and aggregation of amyloid peptides into amyloid fibrils are common and critical pathological events in many neurodegenerative diseases. Most inhibitors or drugs have been developed to prevent amyloid aggregation of a specific peptide, showing sequence-dependent inhibition mechanisms. It is more challenging to develop or discover inhibitors capable of preventing the aggregation of two or more different amyloid peptides. Genistein, a major phytoestrogen in soybean, has been widely used as an anti-inflammation and cerebrovascular drug due to its antioxidation and antiacetylcholinesterase effects. Herein, we examine the inhibitory effects of genistein on the aggregation of amyloid-β (Aβ, associated with Alzheimer's disease) and human islet amylin (hIAPP, associated with type 2 diabetes) and Aβ- and hIAPP-induced neurotoxicity using a combination of experimental and computational approaches. Collective experimental results from thioflavin T (ThT), atomic force microscopy (AFM), and circular dichroism (CD) demonstrate that genistein shows strong inhibition ability to prevent the conformational transition of both Aβ and hIAPP monomers to β-sheet structures, thus reducing final amyloid fibrillization from Aβ and hIAPP monomer aggregation by 40-63%. Further 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT), lactate dehydrogenase (LDH), and large unilamellar vesicle (LUV) assays show that genistein helps to increase cell viability, decrease cell apoptosis, and reduce cell membrane leakage, where the cell protection effect of genistein is likely correlated with its reduced membrane leakage. Comparative molecular dynamics (MD) simulations reveal that genistein prefers to bind the β-sheet groove, a common structural motif of amyloid fibrils, of both Aβ and hIAPP oligomers to interfere with their self-aggregation. This work for the first time demonstrates genistein as a dual inhibitor of Aβ and hIAPP aggregation. Further structural optimization and refinement of genistein may generate a series of effective sequence-independent inhibitors against the aggregation and toxicity of different amyloid peptides.

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“…Reorientation of BC fibres is a main deformation mechanism under global stretching. A challenge to control the orientation of BC fibres attracted an increasing interest since it shows an opportunity to affect a cell-culturing direction (Shi et al, 2018). Sehaqui et al (2012a) prepared isotropic nanopaper and used cold drawing to investigate the possibility of quality control of the orientation of cellulose nanofibres.…”

Section: Discussionmentioning

confidence: 99%