Microstructure, stability and biocompatibility of hydroxyapatite – titania nanocomposites formed by two step sintering process

Marinescu, Cornelia; Sofronia, Ancuta; Anghel, Elena Maria; Baies, Radu; Constantin, Daniel; Seciu, Ana‐Maria; Gîngu, Oana; Tănăsescu, Speranţa

doi:10.1016/j.arabjc.2017.01.019

Cited by 18 publications

(12 citation statements)

References 45 publications

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“…As shown in Figure a–c, after 3 weeks of culture, the BMSCs maintained their normal fibroblastic phenotype around all F-HA coatings. Overall, the results of cell viability and morphology observations indicated that the F-HA coating had good cytocompatibility . As can be seen from Figure d, the BMSCs attached to the surface of the F-HA coating had tiny filamentous pseudopodia .…”

Section: Results and Discussionmentioning

confidence: 79%

“…Overall, the results of cell viability and morphology observations indicated that the F-HA coating had good cytocompatibility. 44 As can be seen from Figure 10d, the BMSCs attached to the surface of the F-HA coating had tiny filamentous pseudopodia. 45 The findings indicated that F-HA coatings possessed good in vitro cell compatibility and biological activity and promoted cell proliferation without cytotoxicity.…”

Section: Methodsmentioning

confidence: 88%

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Formation of Porous Apatite Layer after Immersion in SBF of Fluorine-Hydroxyapatite Coatings by Pulsed Laser Deposition Improved in Vitro Cell Proliferation

Cao

Lian

Liu

2020

ACS Appl. Bio Mater.

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Fluorine (F), a trace element in bone tissues, promotes cell proliferation and colonization. In this study, fluorinehydroxyapatite (F-HA) coating was manufactured onto titanium substrates using pulsed laser deposition (λ = 1024 nm). The results confirmed that the surface roughness of F-HA coatings was the highest when the deposition time was 60 min. To evaluate the biological activity of the coatings, the coatings were immersed in simulated body fluids at 37 °C for 7 days. It was clearly observed that a new apatite layer showed a micro/nano foam-like porous structure. After annealing treatment, the F-HA coating can promote the transformation of the calcium phosphate crystal phase into the HA phase. Moreover, the mass of F-HA coatings with annealing was increased by 2.3% after immersion. In vitro cytocompatibility of the coatings was evaluated; the cell adhesion and proliferation exposed to F-HA coatings were significantly stimulated and promoted when compared with the control group in the first and second weeks of co-culture (p < 0.05). Thus, F-HA coatings can potentially act as osteoinductive materials for surface functionalization of the bone tissue scaffold.

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Section: Results and Discussionmentioning

confidence: 79%

Section: Methodsmentioning

confidence: 88%

Formation of Porous Apatite Layer after Immersion in SBF of Fluorine-Hydroxyapatite Coatings by Pulsed Laser Deposition Improved in Vitro Cell Proliferation

Cao

Lian

Liu

2020

ACS Appl. Bio Mater.

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“…The cell viability results correlated with PEG amount confirmed that composite 2 showed better biocompatibility. As the amount of PEG increased twice, the biocompatibility increased at the same rate (Marinescu et al, 2019). Figure 9 shows the effect of treatment with nanocomposites on cell viability of L929 fibroblast cells assessed by MTT.…”

Section: Biocompatibility Analysismentioning

confidence: 97%

In Vitro Cytotoxicity Analysis and Synthesis of Biocidal Allicin/Mt/Mma/Peg/Poss Nanocomposites for the Food Packaging

Baysal

2020

Gıda

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In this study, the new nanocomposites were synthesized using antibacterial and antioxidant curcumin (Cr) and allicin (Ac), the high mechanical strength montmorillonite clay (Mt) and biocompatible methylmethacrylate (MMA), polyethylene glycol (PEG) and polyocta-hedral oligomeric silsesquioxanes (POSS) polymers. Firstly, monomer 1 was synthesized by using Ag + -montmorillonite, the curcumin extract and POSS, then the synthesized monomer 1 was interacted with MMA and PEG polymers, and nanocomposites were synthesized. The synthesized nanocomposites were analyzed by using the methods of Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD) and scanning electron microscopy (SEM). After this, the inhibition zones and the surface activity resistances of the nanocomposites were analyzed against the bacteria Escherichia coli (E. coli), Listeria monocytogenes (L. monocytogenes), Salmonella and Staphylococcus aureus (S.aureus) and carried out biocompatibility analysis. According to the analysis results, the nanocomposites have been found to have the strong antibacterial resistance and biocompatibility.

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“…After cooling to room temperature, the solution was filtered using a 0.8 µm filter. Artificial saliva (AS) was prepared according to the recipe proposed by Fletcher et al [27]: 0.2 mM MgCl 2 , 1 mM CaCl 2 , 4 mM Na 2 HPO 4 , 16 mM KCl, 4.5 mM NH 4 Cl and 20 mM HEPES (4-(2-hydroxyethyl)piperazine-1-ethane-sulfonic acid) buffer. The pH of the resulted solution was adjusted to 7.0 with 1 M NaOH and stored at 4°C.…”

Section: Experimental Partmentioning

confidence: 99%

Human Dentine Remineralization Under Non-colagen Materials Action

Zaharia¹,

Plescan²,

Anghel³

et al. 2017

Rev. Chim.

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The purpose of this work is to induce biomimetic remineralization of acid etched coronal human dentine in artificial saliva (AS) under agarose (A) hydrogel or chitosan (CS)-A hydrogel action. The investigations focused on the morphology, chemical composition and crystalline structure of the new remineralized layers grown onto the etched dentinal surface (R) using scanning electron microscopy coupled with energy dispersive X-ray spectrometry and micro-Raman spectroscopy. Experimental results showed that remineralized layers grown in the presence of A or CS-A hydrogels consist in B-type Ca-deficient hydroxyapatite (HAP). After 7 days treatment into artificial saliva under agarose hydrogel, nanorod-like extrafibrilar HAP crystals randomly self-assembled in a discontinuous layer were formed, while in presence of chitosan-agarose hydrogel a continuous compact CS-HAP composite layer was obtained. The new biomimetic layer (A-CS4) formed after 4 days on dentine surface under A-CS hydrogel has higher crystallinity. Longer exposed (7 days) dentine in the presence of agarose hydrogel shows a higher mineral-to-collagen ratio (A7). Since dentine mineralization increases, the collagen quality factor decreases in succession A-CS4]R]A7. Results show a benefic effect of chitosan on remineralization of etched dentine.

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Microstructure, stability and biocompatibility of hydroxyapatite – titania nanocomposites formed by two step sintering process

Cited by 18 publications

References 45 publications

Formation of Porous Apatite Layer after Immersion in SBF of Fluorine-Hydroxyapatite Coatings by Pulsed Laser Deposition Improved in Vitro Cell Proliferation

Formation of Porous Apatite Layer after Immersion in SBF of Fluorine-Hydroxyapatite Coatings by Pulsed Laser Deposition Improved in Vitro Cell Proliferation

In Vitro Cytotoxicity Analysis and Synthesis of Biocidal Allicin/Mt/Mma/Peg/Poss Nanocomposites for the Food Packaging

Human Dentine Remineralization Under Non-colagen Materials Action

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