Microstructure, mechanical properties, in vitro degradation behavior and in vivo osteogenic activities of Zn-1Mg-β-TCP composites for bone defect repair

Yao, Runhua; Zhao, Yuyu; Han, Shuyang; Shan, Ruifeng; Liu, Lin; Sun, Yonghua; Yao, Xiaohong; Wang, Xing; Hang, Ruiqiang

doi:10.1016/j.matdes.2022.111494

“…Epithelial or endothelial cells migrate mainly from the wound margin, while fibroblasts or smooth muscle cells migrate from adjacent tissues [80]. Both types of cells proliferate at this stage, with epithelial or endothelial cells covering the wound surface and forming fibers Vitamin cells, or smooth muscle cells, synthesize and secrete extracellular matrix ingredients, especially hyaluronic acid and proteoglycans; 3) Vascular remodeling stage: Extracellular matrix deposition and remodeling will continue for several months [81].…”

Section: The Degradation Process Of Degradable Metals and The Process...mentioning

confidence: 99%

Untitled

2024

Biomed. Lett.

0

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With the accumulation of data, magnesium-based degradable metal, iron-based degradable metal and zinc-based degradable metal implantable interventional devices have entered the clinic or carried out human experimental studies, and the future prospects are promising. In this paper, the definition, biodegradability and biocompatibility criteria and their classification are reviewed, and the research status and unsolved scientific problems of magnesium-based degradable metals, iron-based degradable metals and zincbased degradable metals are introduced, and the future development opportunities and challenges of degradable metals are prospected. With a deeper understanding of scientific issues such as mechanical adaptation, degradation adaptation and tissue adaptation of degradable metal implants, more new materials, new technologies and new methods of degradable metals will be developed in the future, so as to effectively realize the precise adaptation of the two events of degradable metal material degradation and body tissue repair in time and geometric space.

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“…Epithelial or endothelial cells migrate mainly from the wound margin, while fibroblasts or smooth muscle cells migrate from adjacent tissues [80]. Both types of cells proliferate at this stage, with epithelial or endothelial cells covering the wound surface and forming fibers Vitamin cells, or smooth muscle cells, synthesize and secrete extracellular matrix ingredients, especially hyaluronic acid and proteoglycans; 3) Vascular remodeling stage: Extracellular matrix deposition and remodeling will continue for several months [81].…”

Section: The Degradation Process Of Degradable Metals and The Process...mentioning

confidence: 99%

Untitled

Biomed. Lett.

0

View full text Add to dashboard Cite

With the accumulation of data, magnesium-based degradable metal, iron-based degradable metal and zinc-based degradable metal implantable interventional devices have entered the clinic or carried out human experimental studies, and the future prospects are promising. In this paper, the definition, biodegradability and biocompatibility criteria and their classification are reviewed, and the research status and unsolved scientific problems of magnesium-based degradable metals, iron-based degradable metals and zincbased degradable metals are introduced, and the future development opportunities and challenges of degradable metals are prospected. With a deeper understanding of scientific issues such as mechanical adaptation, degradation adaptation and tissue adaptation of degradable metal implants, more new materials, new technologies and new methods of degradable metals will be developed in the future, so as to effectively realize the precise adaptation of the two events of degradable metal material degradation and body tissue repair in time and geometric space.

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Effects of Si/Zn Co‐Substitution on the Physicochemical Properties, In Vitro Angiogenic Potential, and Osteogenic Activity of β‐Tricalcium Phosphate

He,

Lu,

Xu

et al. 2024

Adv Eng Mater

1

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Zinc ions have shown promising osteogenic activity, while silicon ions promote angiogenesis. In this study, we investigated the effects of silicon doping, zinc doping, and their co‐doping on the physicochemical properties, as well as the in vitro angiogenic and osteogenic activities of β‐tricalcium phosphate (β‐TCP). Our findings revealed that silicon doping primarily occurred on the P1 site, leading to lattice stability disruption in β‐TCP and favoring its transformation into α‐tricalcium phosphate (α‐TCP). Notably, a significant portion of silicon ions distributed on the particle surface. As a result, silicon‐doped TCP (Si‐TCP) exhibited remarkable in vitro mineralization activity. Conversely, zinc doping contributed to stabilizing the β‐TCP phase, even at a sintering temperature of 1200 °C, preventing the formation of α‐TCP. Silicon/zinc co‐doped TCP (Si/Zn‐TCP) displayed comparable physicochemical properties to zinc‐doped TCP (Zn‐TCP), thus demonstrating higher thermal stability than pure β‐TCP. Cell response evaluations indicated excellent biocompatibility for Si‐TCP, Zn‐TCP, and Si/Zn‐TCP. Silicon doping significantly enhanced in vitro angiogenic capability, while zinc doping notably improved osteogenic potential of β‐TCP. Furthermore, the bi‐functional ion co‐doping approach in Si/Zn‐TCP resulted in combined angiogenic promoting from Si‐TCP and osteogenic stimulation from Zn‐TCP. These results highlight the considerable potential of Si/Zn‐TCP for bone defect repair applications.This article is protected by copyright. All rights reserved.

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Microstructure, mechanical properties, in vitro degradation behavior and in vivo osteogenic activities of Zn-1Mg-β-TCP composites for bone defect repair

Cited by 11 publications

References 78 publications

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Effects of Si/Zn Co‐Substitution on the Physicochemical Properties, In Vitro Angiogenic Potential, and Osteogenic Activity of β‐Tricalcium Phosphate

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