Microstructure and structural transition in microemulsions stabilized by aldonamide-type surfactants

Zielińska, Katarzyna; Wilk, Kazimiera A.; Jezierski, Adam; Jesionowski, Teofil

doi:10.1016/j.jcis.2008.02.016

Cited by 50 publications

(21 citation statements)

References 50 publications

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“…For example, the dimensions of microemulsions formed at 25 and 55°C in the system C 12 -DGA:iso-butanol/iso-octane/water decrease, respectively, from 5.48 to 3.40 nm (see data in Table 1). Droplet sizes are in accordance with previous investigations on similar systems [32] and they are also similar to those obtained by other authors for sugar-based surfactant microemulsions [25]. The R h value is slightly dependent on the surfactant structure; somewhat bigger droplets appear in the case of the dicephalic surfactant containing the lactobionyl moiety (C 12 -DLA).…”

Section: Dimensions Of C 12 -Dx/iso-butanol/oil/water Microemulsion Dsupporting

confidence: 91%

“…The temperature dependencies for the studied C 12 -DLA are much stronger than those observed for the microemulsions stabilized by single-head single-tail N-alkyl-N-methylgluconamide [32]. Fig.…”

Section: Epr Study On C 12 -Dx/iso-butanol/oil/water Systems At Variomentioning

confidence: 71%

“…It has less impact on the natural environment, thus fulfilling green chemistry principles. Owing to our continuous efforts in designing, synthesizing and characterizing aggregation phenomena and performance properties of a variety of saccharide-derived surfactants [29][30][31][32], we examined pseudoternary phase systems containing N-dodecyl-N,N-bis[(3-D-aldonylamido)propyl]amines [33,34] (for structures and abbreviations see Scheme 1), water, iso-butanol as the cosurfactant, and iso-octane, diethylene glycol monoethyl ether (DGME) as the oils. The prepared surfactants C 12 -DGA and C 12 -DLA represent a new group of dicephalic aldonamide-type derivatives exhibiting profound surface properties.…”

Section: Introductionmentioning

confidence: 99%

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Biocompatible microemulsions of dicephalic aldonamide-type surfactants: Formulation, structure and temperature influence

Wilk

Zielińska

Hamerska-Dudra

et al. 2009

Journal of Colloid and Interface Science

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Section: Dimensions Of C 12 -Dx/iso-butanol/oil/water Microemulsion Dsupporting

confidence: 91%

Section: Epr Study On C 12 -Dx/iso-butanol/oil/water Systems At Variomentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

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Biocompatible microemulsions of dicephalic aldonamide-type surfactants: Formulation, structure and temperature influence

Wilk

Zielińska

Hamerska-Dudra

et al. 2009

Journal of Colloid and Interface Science

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“…Fluorescence measurements of the hydrophobic probe mainly depend on the polarity of the medium, and hence in bicontinuous microemulsions, it is a good indication of the polarity of the microenvironment in the microemulsion structure (36,37). The fluorescence spectra for pyrene molecule in water, individual oil phase, in alcohols (i.e., ethanol and methanol), and in ethanol/oil are shown in Fig.…”

Section: Fluorescence Measurementsmentioning

confidence: 99%

Microemulsion System with Improved Loading of Piroxicam: A Study of Microstructure

2009

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Abstract. Formulation of a new oil-in-water (o/w) microemulsion composed of castor oil/Tween 80/ ethanol/phosphate buffer for enhancing the loading capacity of an anti-inflammatory drug piroxicam has been accomplished. The pseudo-ternary phase diagram has been delineated at constant surfactant/ cosurfactant ratio (1:2). The internal structure of so created four-component system was elucidated by means of an analysis of isotropic area magnitudes in the phase diagram. Conductivity (σ), kinematic viscosity (k η ), and surface tension (γ) studies with the variation in Φ w (weight fraction of aqueous phase) show the occurrence of structural changes from water-in-oil (w/o) microemulsion to oil-in-water (o/w). Along with the solubility and partition studies of piroxicam in microemulsion components, the changes in the microstructure of the microemulsion after incorporation of drug have been evaluated using pH, σ, γ, k η , and density studies. Piroxicam, a poorly water-soluble drug displayed high solubility (1.0%) in an optimum microemulsion formulation using ethanol (55.0%), Tween 80 (26.5%), castor oil (7.5%), and phosphate buffer (11.0%). The results have shown that the microemulsion remained stable after the incorporation of piroxicam. Fluorescence spectra analysis taking pyrene as fluorescent probe was performed, and the results showed that pyrene was completely solubilized in the oil phases of the bicontinuous microemulsions. The fluorescence spectrum of the model drug piroxicam was used to probe the intramicellar region of nonionic microemulsion. The results showed that the piroxicam was localized in the interfacial film of microemulsion systems more deeply in the palisade layer with ethanol as the cosurfactant.

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“…It can be seen from Figure 7 that the -average diameters of CTAB/1-butanol/water reverse micelles are higher than the corresponding CTAB/1-butanol/cyclohexane/water microemulsions and decrease with increasing . The larger size at = 3.64 is due to the formation of CTAB reverse micelles ( / microemulsions) in 1-butanol where the electrostatic repulsion between the polar heads is screened by 1-butanol and facilitates the formation of aggregates as well as larger size of the droplets [42]. As the increases, the droplet sizes decrease possibly due to the decrease in the number of reverse micelles.…”

Section: Droplet Sizes Of Ctab/cyclohexane/1-butanol/watermentioning

confidence: 99%

Acid Hydrolysis of Bromazepam Catalyzed by Micelles, Reverse Micelles, and Microemulsions

Begum¹,

Mollah²,

Rahman³

et al. 2015

Journal of Chemistry

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Kinetics of the acid hydrolysis of bromazepam (Bz) has been investigated in micelles, reverse micelles, and microemulcions of cetyltrimethylammonium bromide (CTAB) by spectrophotometric method. The rate of the acid hydrolysis of Bz was found to be enhanced both below and above the critical micelle concentration (CMC) of CTAB in aqueous solution. The pseudo-first-order rate constant ( ) shows an initial decrease for both low and high H + concentrations. With further increase in [CTAB], at low [H + ], the attains an almost constant value, while, at high [H + ], the passes through a maximum and then decreases. The kinetic data for catalysis by micelles of CTAB was interpreted with the pseudophase ion exchange (PIE) model. In CTAB/cyclohexane/1-butanol/water microemulsions, as the water to surfactant ratio ( ) increases, the physicochemical properties and droplet sizes of microemulsions significantly change and distinct changes in reaction environment can be marked. The rate of the hydrolysis reaction exhibits excellent correlation with the physicochemical properties and droplet sizes of the microemulsions and reverse micelles of CTAB. At [H + ] = 0.001 M, in reverse micelles and microemulsions of CTAB, the of the acid hydrolysis of Bz decreases sharply followed by a slight increase with increasing .

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Microstructure and structural transition in microemulsions stabilized by aldonamide-type surfactants

Cited by 50 publications

References 50 publications

Biocompatible microemulsions of dicephalic aldonamide-type surfactants: Formulation, structure and temperature influence

Biocompatible microemulsions of dicephalic aldonamide-type surfactants: Formulation, structure and temperature influence

Microemulsion System with Improved Loading of Piroxicam: A Study of Microstructure

Acid Hydrolysis of Bromazepam Catalyzed by Micelles, Reverse Micelles, and Microemulsions

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