Biocompatible microemulsions of dicephalic aldonamide-type surfactants: Formulation, structure and temperature influence

Wilk, Kazimiera A.; Zielińska, Katarzyna; Hamerska-Dudra, Agnieszka; Jezierski, Adam

doi:10.1016/j.jcis.2009.03.071

Cited by 41 publications

(18 citation statements)

References 62 publications

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“…BT is considered one of the best cosurfactants for the preparation of microemulsion 11,[36][37][38] and the concentration used in this study is considered residual and non-toxic. 39 The HLB of the surfactant mixture and the composition required to achieve an HLB corresponding to the oily phase was calculated.…”

Section: Determination Of the Surfactant Mixing Ratiomentioning

confidence: 99%

Microemulsion of Brazil nut oil as a natural product to improve superoxide release in human phagocytes

et al. 2017

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The aim of this study was to develop and characterize a Brazil nut oil microemulsion system and determine the effect of this microemulsion on the superoxide release in human phagocytes. The microemulsion was formulated using distilled water, Brazil nut as the oily phase, Sorbitan monooleate, Polysorbate 80, and butan-1-ol. Hydrophile-lipophile balance of Brazil nut oil was determined, pseudoternary diagrams were prepared, and microemulsion diagram regions were preselected. Preliminary and accelerated stability tests, rheological characterization and dynamic light scattering were performed. The immunomodulatory effect of the microemulsion on the interactions with leukocytes was determined by superoxide release. The developed formulations were classified as oil-in-water, showed a Newtonian profile, with linear viscosity and droplet sizes of 46.9; 66.5 and 34.3 nm. When we assessed the interaction of the microemulsion of Brazil nut oil with phagocytes, we observed an increase in superoxide release. Our findings indicate that the developed formulation improved the immunomodulatory activity of the Brazil nut oil, proving to be a natural product option for future applications, in particular for infectious diseases.

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Section: Determination Of the Surfactant Mixing Ratiomentioning

confidence: 99%

Microemulsion of Brazil nut oil as a natural product to improve superoxide release in human phagocytes

et al. 2017

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“…These mixtures were vigorously mixed using a magnetic stirrer and diluted dropwise with double distilled water at 25 ± 1°C. The samples were classified as microemulsions when they appeared as clear liquids (23). The microemulsion region of the system was constructed on a triangular graph using SigmaPlot®12.0 software.…”

Section: Pseudo Ternary Phase Diagram Constructionmentioning

confidence: 99%

A Novel Microemulsion System for Ocular Delivery of Azithromycin: Design, Characterization and Ex-Vivo Rabbit Corneal Permeability

Salimi

Panahi-Bazaz

2017

Jundishapur J Nat Pharm Prod

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Background: The poor bioavailability of ophthalmic drops is mainly due to the rapid nasolacrimal drainage of the drug and very low permeability of corneal epithelium. Hence, there is an interest to find an effective system to improve drug permeability and bioavailability. Objectives: The aim of the present study was to design and characterize a novel microemulsion system as an ocular delivery system for Azithromycin and evaluate its physicochemical characteristics and rabbit corneal permeability in order to enhance the penetration of the drug. Methods: The prepared microemulsions (MEs) were assessed for their viscosity, pH, particle size, surface tension, DSC, stability, in vitro drug release, and corneal rabbit permeability. In this study, a full factorial design was employed with 3 variables at 2 levels for preparing 8 formulations and data analysis. Results:The results showed that the average droplet size of ME formulations was in the range of 6.78 to 26.65 nm while pH values were 5.1 to 5.7 and viscosity range was 115 -361 cps. Drug release profile revealed that 79.066% of the drug released in 24 hours of the experiment. The maximum and minimum percentages of drug permeated through rabbit cornea were observed in MEA-7 (12.87%) and MEA-2 (0.909%), respectively. All ME formulations with different compositions and properties significantly increased partitioning, flux, and permeability coefficient from rabbit cornea. Dapp and Papp parameters in MEA-1 and MEA-7 formulations were 0.00882 cm 2 h -1 and 2.391 cmh -1 , which were 17.65, 35.17 times higher than those of control (AZ suspension, 1%), respectively. The

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“…The samples were classified as NEs when they appeared as clear liquids. [11] Preparation of NEs NE samples selected from the constructed phase diagrams were prepared based on the composition as shown in Table 1. The full factorial design was used concerning with 3 variables at 2 levels for preparing eight NE formulations.…”

Section: Construction Of Phase Diagrammentioning

confidence: 99%

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Salimi

2017

AJP

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Introduction: Poor bioavailability of drugs from ocular dosage forms is mainly due to the tear production, nonproductive absorption, transient residence time, and impermeability of corneal epithelium. The aim of the present study was to design, characterize of a novel nanoemulsion (NE) system as an ocular delivery system for celecoxib (CXB) and to evaluate its physicochemical characteristics and rabbit corneal permeability to enhance the penetration of the drug. Methods: CXB NEs were prepared by testing its solubility in oils, surfactants, and cosurfactants. Utilizing pseudoternary phase diagram, the optimum ratios were chosen and full factorial design was used with 3 variables at 2 levels for preparing eight formulations. The prepared NEs were evaluated regarding their viscosity, pH, particle size, differential scanning calorimetry thermograms, stability, in vitro drug release, and corneal rabbit permeability. Results and Discussion: The results showed that the mean droplet size range of NE formulations was in the range of 6.96-26.65 nm and pH was 6.5-6.9, respectively. Viscosity range was 118-245 cps. Drug release profile showed that 82.6% of the drug released in the 24 h of the experiment. The maximum and minimum drug permeated percentage through rabbit cornea was observed in NE component (NEC)-5 (15.73%) and NEC-1 (6.1%), respectively. All NE formulations with different compositions and properties significantly increased partitioning, flux, and permeability coefficient from rabbit cornea. Dapp and Papp parameters in NEC-3 and NEC-5 formulation were 0.0233 cm 2 h

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Biocompatible microemulsions of dicephalic aldonamide-type surfactants: Formulation, structure and temperature influence

Cited by 41 publications

References 62 publications

Microemulsion of Brazil nut oil as a natural product to improve superoxide release in human phagocytes

Microemulsion of Brazil nut oil as a natural product to improve superoxide release in human phagocytes

A Novel Microemulsion System for Ocular Delivery of Azithromycin: Design, Characterization and Ex-Vivo Rabbit Corneal Permeability

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