Microstructure and release characteristics of the minipellet, a collagen-based drug delivery system for controlled release of protein drugs

Maeda, Miho; Tani, Shohei; Sano, Akihiko; Fujioka, Keiji

doi:10.1016/s0168-3659(99)00156-x

Cited by 150 publications

(92 citation statements)

References 13 publications

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“…Since then, the effectiveness of ACSs loaded with other BMPs and growth factors, such as transforming growth factor (TGF) and fi broblast growth factor (FGF), has also been examined [21][22][23] . Nevertheless, collagen has rather limited controlled release capacity, with most of the release occurring in the first day 1) . Apart from its limited capacity to control rhBMP-2, the main limitations of collagen scaff olds derive from their poor mechanical properties.…”

Section: Discussionmentioning

confidence: 99%

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Histological Comparison of Autogenous and Allogenic Demineralized Dentin Matrix Loaded with Recombinant Human Bone Morphogenetic Protein-2 for Alveolar Bone Repair: A Preliminary Report

Jun

Yun

et al. 2017

J. Hard Tissue Biology.

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The goal of investigation is to examine the histological response to recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded demineralized dentin matrices (DDMs) of different origins. The evaluation site is chosen between the cover screw and gingiva, as the poor blood supply allows it to simulate a heterotopic condition. We hypothesize that the antigenicity and immunogenicity of the carrier allogenic DDMs are low enough to maintain both the biocompatibility of the scaff old and the activity of the loaded rhBMP-2. Three patients undergoing simultaneous implant placement and receiving a diff erent type of graft were included: allogenic DDM loaded with rhBMP-2(DDM/rhBMP-2), autogenous DDM/rhBMP-2 and autogenous DDM. Histological specimens were retrieved during the secondary surgery after 3-6 months. In histological examination, particles were encapsulated by dense fi brous tissue without any infl ammatory cells. The capsule contained an increased number of cell layers in the DDM/rhBMP-2 (allogenic and autogenous) compared to autogenous DDM. Resorption activity was higher in autogenous DDM/rhBMP-2 than in allogenic DDM/rhBMP-2. Within the limitations of this report, results demonstrated the successful use of DDM as a potential rhBMP2 carrier. Further studies will be required to confi rm the safety and eff ectiveness of autogenous and allogenic DDM/rhBMP-2.

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Section: Discussionmentioning

confidence: 99%

“…Nevertheless, collagen has a rather limited capacity for controlled release, with most of the absorbed agent released during the fi rst day post-implantation 1) . Release properties can be improved to a limited extent by cross-linking 2) .…”

Section: Introductionmentioning

confidence: 99%

Histological Comparison of Autogenous and Allogenic Demineralized Dentin Matrix Loaded with Recombinant Human Bone Morphogenetic Protein-2 for Alveolar Bone Repair: A Preliminary Report

Jun

Yun

et al. 2017

J. Hard Tissue Biology.

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“…For this reason, other sources of collagen, such as recombinant forms, are seen as an alternative. Collagen exhibits biodegradability, weak antigenicity and superior biocompatibility (Maeda et al, 1999;Lee et al, 2001). This material is regarded as very promising for the delivery of growth factors, as it was found that an electrostatic interaction was the main driving force for the complexation between acidic gelatin and basic fibroblast growth factor (bFGF) .…”

Section: Incorporation and Releasementioning

confidence: 99%

Materials in particulate form for tissue engineering. 1. Basic concepts

Silva

Ducheyne

Reis

2007

J Tissue Eng Regen Med

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For biomedical applications, materials small in size are growing in importance. In an era where 'nano' is the new trend, micro-and nano-materials are in the forefront of developments. Materials in the particulate form aim to designate systems with a reduced size, such as micro-and nanoparticles. These systems can be produced starting from a diversity of materials, of which polymers are the most used. Similarly, a multitude of methods are to produce particulate systems, and both materials and methods are critically reviewed here. Among the varied applications that materials in the particulate form can have, drug delivery systems are probably the most prominent, as these have been in the forefront of interest for biomedical applications. The basic concepts pertaining to drug delivery are summarized, and the role of polymers as drug delivery systems conclude this review. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE R E V I E W A R T I C L E

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“…Moreover, it is non toxic, biocompatible and biodegradable. It has high tensile strength and high affinity with water [7,8].…”

Section: Collagenmentioning

confidence: 99%

Biomedical Biopolymers, their Origin and Evolution in Biomedical Sciences: A Systematic Review

Yadav

Yadav²,

Shah

et al. 2015

JCDR

112

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Microstructure and release characteristics of the minipellet, a collagen-based drug delivery system for controlled release of protein drugs

Cited by 150 publications

References 13 publications

Histological Comparison of Autogenous and Allogenic Demineralized Dentin Matrix Loaded with Recombinant Human Bone Morphogenetic Protein-2 for Alveolar Bone Repair: A Preliminary Report

Histological Comparison of Autogenous and Allogenic Demineralized Dentin Matrix Loaded with Recombinant Human Bone Morphogenetic Protein-2 for Alveolar Bone Repair: A Preliminary Report

Materials in particulate form for tissue engineering. 1. Basic concepts

Biomedical Biopolymers, their Origin and Evolution in Biomedical Sciences: A Systematic Review

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