Microstructure analysis and corrosion behavior of biodegradable Mg–Ca implant alloys

Rad, Hamid Reza Bakhsheshi; Idris, Mohd Hasbullah; Kadir, Mohammed Rafiq Abdul; Farahany, Saeed

doi:10.1016/j.matdes.2011.06.057

Cited by 219 publications

(91 citation statements)

References 25 publications

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“…When Ca is present, Mg alloys develop a hydroxyapatite (HA) surface layer, improving its biocompatibility. Ca is also a grain refiner [153] improving mechanical properties. Zhang and Yang [154] reported a decrease in grain size from 175 to 51 μm in Mg-Zn-Mn alloys increasing the amount of Ca from 0.3 to 1 wt %.…”

Section: Calciummentioning

confidence: 99%

Mg and Its Alloys for Biomedical Applications: Exploring Corrosion and Its Interplay with Mechanical Failure

Peron

Torgersen

Berto

2017

Metals

101

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Abstract:The future of biomaterial design will rely on temporary implant materials that degrade while tissues grow, releasing no toxic species during degradation and no residue after full regeneration of the targeted anatomic site. In this aspect, Mg and its alloys are receiving increasing attention because they allow both mechanical strength and biodegradability. Yet their use as biomedical implants is limited due to their poor corrosion resistance and the consequential mechanical integrity problems leading to corrosion assisted cracking. This review provides the reader with an overview of current biomaterials, their stringent mechanical and chemical requirements and the potential of Mg alloys to fulfil them. We provide insight into corrosion mechanisms of Mg and its alloys, the fundamentals and established models behind stress corrosion cracking and corrosion fatigue. We explain Mgs unique negative differential effect and approaches to describe it. Finally, we go into depth on corrosion improvements, reviewing literature on high purity Mg, on the effect of alloying elements and their tolerance levels, as well as research on surface treatments that allow to tune degradation kinetics. Bridging fundamentals aspects with current research activities in the field, this review intends to give a substantial overview for all interested readers; potential and current researchers and practitioners of the future not yet familiar with this promising material.

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Section: Calciummentioning

confidence: 99%

Mg and Its Alloys for Biomedical Applications: Exploring Corrosion and Its Interplay with Mechanical Failure

Peron

Torgersen

Berto

2017

Metals

101

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“…Most of the magnesium alloys that have been studied for biodegradable implant applications contain secondary phase particles : for example, Mg 17 Al 12 (β-phase) in AZ series alloy 11,12) , Mg 12 YNd and Mg 14 YNd 2 in WE43 alloy 13) , and Mg 2 Ca in Mg-Ca alloys 14) . The in vitro and in vivo degradation studies carried out on these secondary phase particles containing magnesium alloys have only focused on the overall corrosion behaviour of the alloy.…”

Section: Secondary Phase Particlesmentioning

confidence: 99%

Biodegradation of Secondary Phase Particles in Magnesium Alloys: A Critical Review

Kannan¹

2016

Corrosion Science and Technology

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Magnesium alloys have been extensively studied in recent years for potential biodegradable implant applications. A great deal of work has been done on the evaluation of the corrosion behaviour of magnesium alloys under in vitro and in vivo conditions. However, magnesium alloys, in general, contain secondary phase particles distributed in the matrix and/or along the grain boundaries. Owing to their difference in chemistry in comparison with magnesium matrix, these particles may exhibit different corrosion behaviour. It is essential to understand the corrosion behaviour of secondary phase particles in magnesium alloys in physiological conditions for implant applications. This paper critically reviews the biodegradation behaviour of secondary phase particles in magnesium alloys.

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“…Since most Mg-based alloys [8][9][10][11][12][13][14] currently studied for orthopedic applications contain Ca as the major solute species, we selected Mg-5Ca as the composition of the base alloy. To this composition, we added a minor amount (1%) of Zn based on the following considerations.…”

Section: Alloy Selectionmentioning

confidence: 99%

“…Of the various techniques that have been developed, to overcome the poor corrosion resistance of Mg alloys, those based on minor alloying [8][9][10][11][12][13][14] and mechanical working [15][16][17] have been extensively studied. Various biodegradable Mg alloys such as Mg-Ca, 8,9 Mg-Zn-Ca, [10][11][12] Mg-Bi-Ca, 13 and Mg-Si-Ca 14 have been recently documented in the literature, while conventional extrusion 15,16 and severe plastic deformation 17 have 18 attempted to create such a technique by tailoring the electrochemical properties and microstructure of constituent phases and its results can be viewed as a stepping stone in the ongoing search for a highly efficient method.…”

Section: Introductionmentioning

confidence: 99%

“…Various biodegradable Mg alloys such as Mg-Ca, 8,9 Mg-Zn-Ca, [10][11][12] Mg-Bi-Ca, 13 and Mg-Si-Ca 14 have been recently documented in the literature, while conventional extrusion 15,16 and severe plastic deformation 17 have 18 attempted to create such a technique by tailoring the electrochemical properties and microstructure of constituent phases and its results can be viewed as a stepping stone in the ongoing search for a highly efficient method. In this study, comparative studies of Mg-5Ca and Mg5Ca-1Zn (in Wt %) were conducted in order to explore how and why the minor alloying with Zn in a Mg-5Ca binary alloy and subsequent hot extrusion can simultaneously improve both its strength and corrosion resistance.…”

Section: Introductionmentioning

confidence: 99%

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In vitrodynamic degradation behavior of new magnesium alloy for orthopedic applications

Yang

Kim

Han

et al. 2014

J. Biomed. Mater. Res.

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We report on methodologies for use in the design of a biodegradable Mg alloy appropriate for load-bearing but temporary orthopedic implant applications. Comparative studies of Mg-5Ca and Mg-5Ca-1Zn were conducted to explore the effects of a combination of minor alloying and hot extrusion, on the alloy's mechanical properties and corrosion resistance. The extruded Mg-5Ca-1Zn exhibited high ultimate compressive strength of 385 MPa and suffered no significant structural degradation even after immersion in simulated body fluid for 30 days. Mg-5Ca-1Zn alloy showed the mechanical strength and controlled corrosion rate to be considered as an ideal candidate for biodegradable orthopedic implant material.

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Microstructure analysis and corrosion behavior of biodegradable Mg–Ca implant alloys

Cited by 219 publications

References 25 publications

Mg and Its Alloys for Biomedical Applications: Exploring Corrosion and Its Interplay with Mechanical Failure

Mg and Its Alloys for Biomedical Applications: Exploring Corrosion and Its Interplay with Mechanical Failure

Biodegradation of Secondary Phase Particles in Magnesium Alloys: A Critical Review

In vitrodynamic degradation behavior of new magnesium alloy for orthopedic applications

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