In vitrodynamic degradation behavior of new magnesium alloy for orthopedic applications

Abstract

We report on methodologies for use in the design of a biodegradable Mg alloy appropriate for load-bearing but temporary orthopedic implant applications. Comparative studies of Mg-5Ca and Mg-5Ca-1Zn were conducted to explore the effects of a combination of minor alloying and hot extrusion, on the alloy's mechanical properties and corrosion resistance. The extruded Mg-5Ca-1Zn exhibited high ultimate compressive strength of 385 MPa and suffered no significant structural degradation even after immersion in simulated body fluid for 30 days. Mg-5Ca-1Zn alloy showed the mechanical strength and controlled corrosion rate to be considered as an ideal candidate for biodegradable orthopedic implant material.

Biomechanical comparison of pure magnesium interference screw and polylactic acid polymer interference screw in anterior cruciate ligament reconstruction—A cadaveric experimental study

“…Because of the Mg effect on promotion of healing and remodelling of the regenerated hard and soft tissue, the Mg-based interference screws were developed in the present study for a relevant clinical indication for ACL reconstruction. As Mg has been shown to promote bone regeneration in many preclinical and clinical studies [1] , [11] , [12] , [13] , [14] , the use of the interference screws may have potential benefits in healing of the graft in the bone tunnel, as reported in recent animal experimental studies [26] .…”

“…In recent years, degradable metals, such as magnesium (Mg) and its alloys, have been intensively investigated preclinically [11] , [12] , and clinical trials were also conducted to study their potential orthopaedic applications [1] , [13] , [14] , as they possess desirable mechanical properties, good biocompatibility, and biodegradability [15] , [16] . The lower moduli compared with permanent metals such as titanium-based materials make the mechanical properties of pure Mg or its alloys closer to those of the cortical bone, which could reduce the level of stress shielding effects during fracture fixation [17] .…”

“…There are extensive clinical studies to support its in vivo applications [22] , [23] . To date, there have been three clinical trial studies reported in Germany for its indications [1] , in Korea for its applications [13] , and most recently in China for its application in fixing bony flap in femoral head osteonecrosis [14] based on relevant preclinical experimental models. ACL reconstruction is a clinical routine and has considerable potential for indication of Mg-based interference screws [24] , [25] .…”

Bioabsorbable Osteofixation Materials for Maxillofacial Bone Surgery: A Review on Polymers and Magnesium-Based Materials

“… Data were compiled from Byun et al 2020 [ 118 ], Byun et al 2020 [ 119 ], and Yang et al 2014 [ 120 ]. * Plates were coated with poly- l -lactic acid (PLLA).…”

Localized Corrosion of Binary Mg–Ca Alloy in 0.9 wt% Sodium Chloride Solution

“…The galvanic corrosion between Mg 2 Ca and Mg matrix around the eutectic micro-constituent inevitably occurs on the surface when the sample is immersed in an aqueous solution. The Mg matrix around Mg 2 Ca particles acted as local cathodes is protected by galvanic effect [53], and the evolution of H 2 on these zone prevents the coverage of corrosion products. This is the reason for the light spots observed in optical microscopy.…”