Microstructural white matter abnormalities in type 2 diabetes mellitus: A diffusion tensor imaging study

Hsu, Jung Lung; Chen, Yen Ling; Leu, Jyu Gang; Jaw, Fu Shan; Lee, Cheng Hui; Tsai, Yuh Feng; Hsu, Chien‐Yeh; Bai, Chyi Huey; Leemans, Alexander

doi:10.1016/j.neuroimage.2011.09.041

Cited by 175 publications

(171 citation statements)

References 56 publications

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“…This finding complements previous studies on frontal WM impairments in diabetes (Ajilore et al, 2007, Hsu et al, 2012. For example, Hsu et al found lower FA values in bilateral frontal WM in type 2 diabetic subjects compared to healthy controls.…”

Section: Tracts Of Alic In Depression and Diabetessupporting

confidence: 91%

“…For example, Hsu et al found lower FA values in bilateral frontal WM in type 2 diabetic subjects compared to healthy controls. Furthermore, the significant negative correlation between diabetes severity and FA of the left ALIC agrees with the finding from the same study where they found a significant association between disease duration and microstructural properties in several brain regions including bilateral cerebellum, bilateral cingulate gyrus and pons (Hsu et al, 2012). The involvement of the left ALIC in diabetes and the right ALIC in depression suggest that patients with both diabetes and depression are more likely to have bilateral white matter integrity impairment compared to subjects with either disease alone.…”

Section: Tracts Of Alic In Depression and Diabetessupporting

confidence: 90%

“…Furthermore, myo-inositol concentrations were significantly increased in depressed diabetic subjects as well as diabetic control subjects within the frontal white matter (WM) when compared to healthy controls (Ajilore et al, 2007). Additionally, a recent study by Hsu et al found significantly decreased fractional anisotropy (FA) values in the bilateral frontal WM in type 2 diabetic subjects compared to healthy controls and a significant association between disease duration and microstructural properties in several brain regions including bilateral cerebellum, temporal lobe WM, right caudate, bilateral cingulate gyrus, pons, and parahippocampal gyrus (Hsu et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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White Matter Tract Integrity of Anterior Limb of Internal Capsule in Major Depression and Type 2 Diabetes

Zhang

Ajilore

Zhan³

et al. 2013

Neuropsychopharmacol

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A number of studies have shown an association between diabetes and depression. However, the underlying mechanisms are still unclear. Previous findings indicate a role for the prefrontal cortex and subcortical gray matter regions in type 2 diabetes and major depressive disorder (MDD). The purpose of this study was to examine the white matter integrity in the fibers that are part of the anterior limb of internal capsule (ALIC) in MDD and diabetic subjects using diffusion tensor imaging tractography. We studied 4 groups of subjects including 1) 42 healthy controls (HC), 2) 28 MDD subjects (MD), 3) 24 patients diagnosed with type 2 diabetes without depression (DC), and 4) 22 patients diagnosed with diabetes and depression (DD). Results revealed significantly decreased fractional anisotropy (FA; P ¼ .021) and a trend towards significant increase in radial diffusivity (RD; P ¼ .078) of the right ALIC in depressed subjects (MD þ DD) compared to non-depressed subjects (HC þ DC). While there were no significant diabetes effects or interactions between depression and diabetes, subjects with high depression ratings and high hemoglobin A1c levels had the lowest mean FA values in the right ALIC. In addition, we found a significant negative correlation between FA of the left ALIC with hemoglobin A1c in diabetic subjects (DC þ DD; P ¼ .016). Our study demonstrated novel findings of white matter abnormalities of the ALIC in depression and diabetes. These findings have implications for clinical manifestations of depression and diabetes as well as their pathophysiology.

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Section: Tracts Of Alic In Depression and Diabetessupporting

confidence: 91%

Section: Tracts Of Alic In Depression and Diabetessupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

White Matter Tract Integrity of Anterior Limb of Internal Capsule in Major Depression and Type 2 Diabetes

Zhang

Ajilore

Zhan³

et al. 2013

Neuropsychopharmacol

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“…Type 2 DM is primarily caused by insulin resistance on target tissues and relative insulin deficiency, whereas type 1 DM is mainly caused by insulin deficiency due to the autoimmune-mediated destruction of pancreatic β cells (22). The incidence of type 2 DM due to obesity and associated insulin resistance in childhood and (27,28). The impairment of cognitive function in patients with type 2 DM has also been demonstrated to be correlated to the reduced circulation of the frontal and parietal lobes (29).…”

Section: Discussionmentioning

confidence: 99%

Association of attention-deficit/hyperactivity disorder with diabetes: a population-based study

et al. 2013

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Background: cognitive impairment has been documented in adult diabetes but is unclear in pediatric diabetes. No study had been conducted to explore the relationship between attention-deficit/hyperactivity disorder (aDhD) and diabetes. Using a population-based data set, we aimed to examine the association between aDhD and a prior diagnosis of diabetes mellitus (DM) in Taiwan. Methods: a total of 4,302 patients with aDhD were selected as cases and 21,510 randomly selected subjects as controls. We used conditional logistic regression to calculate the odds ratio (OR) for having previously received a diagnosis of DM between subjects with and without aDhD. results: In this study, 116 of the 25,812 sampled subjects (0.5%) had received a diagnosis of DM prior to their index date. subjects with aDhD had a higher proportion of prior DM diagnoses than controls (0.9% vs. 0.4%, P < 0.001). after adjusting for age, sex, index year, geographic location, and obesity, aDhD was significantly associated with a prior diagnosis of type 2 DM (OR = 2.75, 95% confidence interval (cI) = 1.82-4.16). however, no significant association was observed between aDhD and type 1 DM. conclusion: The findings suggest that aDhD was associated with a previous diagnosis of type 2 DM.

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“…[73][74][75] In population-based cohorts, alterations in DTI parameters have been associated with an unfavorable vascular risk factor profile. 76,77 Diffusion tensor imaging parameters have also found to be altered in patients with probable CAA (Figure 2). [78][79][80] A recent study showed that diffusion abnormalities in CAA resemble the distribution of CAA pathology: between-group differences in FA were observed in white-matter tracts projecting onto the posterior cortex (i.e., the occipital, posterior temporal, and parietal lobes), whereas tracts projecting onto subcortical regions were relatively spared ( Figure 2A).…”

Section: Diffusion Tensor Imagingmentioning

confidence: 97%

Ischemic brain injury in cerebral amyloid angiopathy

Reijmer

Veluw

Greenberg

2015

J Cereb Blood Flow Metab

114

100

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Cerebral amyloid angiopathy (CAA) is a common form of cerebral small vessel disease and an important risk factor for intracerebral hemorrhage and cognitive impairment. While the majority of research has focused on the hemorrhagic manifestation of CAA, its ischemic manifestations appear to have substantial clinical relevance as well. Findings from imaging and pathologic studies indicate that ischemic lesions are common in CAA, including white-matter hyperintensities, microinfarcts, and microstructural tissue abnormalities as detected with diffusion tensor imaging. Furthermore, imaging markers of ischemic disease show a robust association with cognition, independent of age, hemorrhagic lesions, and traditional vascular risk factors. Widespread ischemic tissue injury may affect cognition by disrupting white-matter connectivity, thereby hampering communication between brain regions. Challenges are to identify imaging markers that are able to capture widespread microvascular lesion burden in vivo and to further unravel the etiology of ischemic tissue injury by linking structural magnetic resonance imaging (MRI) abnormalities to their underlying pathophysiology and histopathology. A better understanding of the underlying mechanisms of ischemic brain injury in CAA will be a key step toward new interventions to improve long-term cognitive outcomes for patients with CAA.

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Microstructural white matter abnormalities in type 2 diabetes mellitus: A diffusion tensor imaging study

Cited by 175 publications

References 56 publications

White Matter Tract Integrity of Anterior Limb of Internal Capsule in Major Depression and Type 2 Diabetes

White Matter Tract Integrity of Anterior Limb of Internal Capsule in Major Depression and Type 2 Diabetes

Association of attention-deficit/hyperactivity disorder with diabetes: a population-based study

Ischemic brain injury in cerebral amyloid angiopathy

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