Microstructural integrity of a pathway connecting the prefrontal cortex and amygdala moderates the association between cognitive reappraisal and negative emotions.

d’Arbeloff, Tracy; Kim, M Justin; Knodt, Annchen R.; Radtke, Spenser R.; Brigidi, Bartholomew D.; Hariri, Ahmad R.

doi:10.1037/emo0000447

Cited by 31 publications

(28 citation statements)

References 22 publications

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“…The UF is an association fiber extending from ventromedial prefrontal (vmPFC) regions to the amygdala, permitting bi-directional communication. Integrity of this tract has been associated with Stroop task performance (He et al, 2016; Schulte et al, 2012); more broadly, it is involved in emotion regulation (d’Arbeloff et al, 2018; Zheng et al, 2018). Disruptions in UF integrity have been linked to mood, anxiety, and trauma-related disorders (Lindner et al, 2018; Jenkins et al, 2016; Koch et al, 2017; Liao et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Attentional control abnormalities in posttraumatic stress disorder: Functional, behavioral, and structural correlates

Fani

King

Clendinen

et al. 2019

Journal of Affective Disorders

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Background: Attentional disruptions are common in PTSD, but findings across neuropsychological and neuroimaging studies have been variable. Few PTSD studies have investigated abnormalities in attention networks using a multi-modal imaging approach and attentional tasks that include emotionally-salient images. This study combined a behavioral task that included these images (emotional Stroop) with functional and structural neuroimaging (fMRI and diffusion tensor imaging; DTI) methods to comprehensively investigate attentional control abnormalities in a highly-traumatized civilian sample. Methods: 48 traumatized women with and without PTSD received clinical assessments, fMRI and DTI. During fMRI, the Affective Stroop (AS), an attentional control task that includes emotionally-salient distractor images (trauma-relevant, positive, neutral) and variable task demands, was administered. Results: In response to more difficult AS trials, participants with PTSD demonstrated lower activation in the dorsal and rostral anterior cingulate cortex and greater activation in the insula. This group also showed comparatively poorer performance on positive AS distractor trials, even after adjusting for trauma exposure. Performance on these trials inversely correlated with structural integrity of the cingulum bundle and uncinate fasciculus. Conclusions: Even after adjusting for trauma exposure, participants with PTSD showed worse performance on an attentional control task in the context of emotional stimuli. They also showed relatively lower cognitive control network activation and greater salience network activation. Fronto-parietal and fronto-limbic white matter connectivity corresponded with AS performance. Our findings indicate that attentional control impairments in PTSD are most evident in the context of emotional cues, and are related to decrements in function and structure of cognitive control and salience networks.

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Section: Discussionmentioning

confidence: 99%

Attentional control abnormalities in posttraumatic stress disorder: Functional, behavioral, and structural correlates

Fani

King

Clendinen

et al. 2019

Journal of Affective Disorders

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“…The prefrontal lobe plays a key role in emotional and cognitive control [ 53 ]. Previous studies found abnormal neurobiochemistry and neuropathology in the prefrontal lobe in patients with BD.…”

Section: Discussionmentioning

confidence: 99%

Increased Global-Brain Functional Connectivity Is Associated with Dyslipidemia and Cognitive Impairment in First-Episode, Drug-Naive Patients with Bipolar Disorder

et al. 2021

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Objectives. Previous researches have demonstrated that abnormal functional connectivity (FC) is associated with the pathophysiology of bipolar disorder (BD). However, inconsistent results were obtained due to different selections of regions of interest in previous researches. This study is aimed at examining voxel-wise brain-wide functional connectivity (FC) alterations in the first-episode, drug-naive patient with BD in an unbiased way. Methods. A total of 35 patients with BD and 37 age-, sex-, and education-matched healthy controls underwent resting-state functional magnetic resonance imaging (rs-fMRI). Global-brain FC (GFC) was applied to analyze the image data. Support vector machine (SVM) was adopted to probe whether GFC abnormalities could be used to identify the patients from the controls. Results. Patients with BD exhibited increased GFC in the left inferior frontal gyrus (LIFG), pars triangularis and left precuneus (PCu)/superior occipital gyrus (SOG). The left PCu belongs to the default mode network (DMN). Furthermore, increased GFC in the LIFG, pars triangularis was positively correlated with the triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) and negatively correlated with the scores of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) coding test and Stroop color. Increased GFC values in the left PCu/SOG can be applied to discriminate patients from controls with preferable sensitivity (80.00%), specificity (75.68%), and accuracy (77.78%). Conclusions. This study found increased GFC in the brain regions of DMN; LIFG, pars triangularis; and LSOG, which was associated with dyslipidemia and cognitive impairment in patients with BD. Moreover, increased GFC values in the left PCu/SOG may be utilized as a potential biomarker to differentiate patients with BD from controls.

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“…Of particular interest are previous findings suggesting alterations in WM structural integrity may be associated with symptoms related to anxiety and depression ( Baur, Hanggi, & Jancke, 2012 ; Kim & Whalen, 2009 ; Korgaonkar et al, 2011 ; Zuo et al, 2012 ). For instance, it has been suggested that the ability to successfully reappraise an adverse situation may be dependent upon the structural integrity of WM tracts providing connectivity between the amygdala and Prefrontal cortex (PFC) ( d'Arbeloff et al, 2018 ). Fractional anisotropy (FA) is a measure of the directionality of water diffusion in the brain and is commonly reported as a representation of the structural integrity of WM tracts ( Mori & Tournier, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Can measures of sleep quality or white matter structural integrity predict level of worry or rumination in adolescents facing stressful situations? Lessons from the COVID‐19 pandemic

Jamieson

Kannis‐Dymand

Beaudequin

et al. 2021

Journal of Adolescence

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Introduction COVID-19 has resulted in major life changes to the majority of the world population, particularly adolescents, with social-distancing measures such as home-based schooling likely to impact sleep quality. Increased worry is also likely considering the substantial financial, educational and health concerns accompanying COVID-19. White matter (WM) integrity has been shown to be associated with anxiety and depression symptoms, including worry, as well being closely associated with sleep quality. This study aimed to investigate the associations between pre-COVID sleep quality, WM structural integrity and levels of worry and rumination about COVID. Methods N = 30 adolescent participants from Queensland, Australia, completed diffusion tensor imaging (DTI) scanning pre-COVID, the Pittsburgh Sleep Quality Index (PSQI) pre and during COVID, and 9 items designed to measure 3 constructs, perceived impact of COVID, general worry, and COVID-specific worry and rumination. Results Sleep quality (PSQI total) was significantly poorer during COVID compared with pre-COVID. Sleep onset latency measured pre-COVID was significantly associated with COVID-specific worry and rumination. While the structural integrity of a number of WM tracts (measured pre-COVID) were found to be significantly associated with COVID-specific worry and rumination. Follow-up regression analysis using a model including pre-COVID sleep onset latency, structural integrity of the posterior limb of the internal capsule (PLIC), gender and change in PSQI explained a significant 47% of the variance in COVID-specific worry and rumination. Conclusions These findings suggest that adolescents with poor sleep quality and perturbed WM integrity may be at risk of heightened reactivity to future stressful events and interventions should focus on improving sleep onset latency.

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Microstructural integrity of a pathway connecting the prefrontal cortex and amygdala moderates the association between cognitive reappraisal and negative emotions.

Cited by 31 publications

References 22 publications

Attentional control abnormalities in posttraumatic stress disorder: Functional, behavioral, and structural correlates

Attentional control abnormalities in posttraumatic stress disorder: Functional, behavioral, and structural correlates

Increased Global-Brain Functional Connectivity Is Associated with Dyslipidemia and Cognitive Impairment in First-Episode, Drug-Naive Patients with Bipolar Disorder

Can measures of sleep quality or white matter structural integrity predict level of worry or rumination in adolescents facing stressful situations? Lessons from the COVID‐19 pandemic

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