The aim of this work was to study effects of hot extrusion on the microstructure of Ti-6Al-4V (wt-%) alloy processed by ECAP. Firstly, an isothermally Ti–6Al–4V alloy processed by Equal channel angular pressing(ECAP) was preheated at 950°C for 6 min and then hot extruded at 900°C. The hot extrusion minimised the grain size and maximised the mechanical strength. Therefore, it was demonstrated that hot extrusion of Ti-6Al-4V alloys that processed by ECAP could be performed without compromising any mechanical properties. Therefore, it is possible to use the ability to apply a reduced cross-section in hot extrusion for an Ti-6Al-4V processed by ECAP without concern about the reduction of properties.