In 3D packaging memory devices, solder joints are critical links between the chip and the printed circuit board (PCB). Under severe working conditions, cracks inevitably occur due to thermal shock. If cracks grow in the solder joint, the chip will be disconnected with the PCB, causing its function failure. In this paper, the reliability of solder joints under thermal shock are evaluated for 3D packaging memory devices by means of the SEM and finite element analysis. As microscopically studied by the SEM, it is found out that the main failure mechanism of solder joints in such test is the thermal fatigue failure of solder joints. Finite element analysis shows that cracks are caused by the accumulation of plastic work and creep strain. The initiation and growth of cracks are mainly influenced by the inelastic strain accumulation. The trends of cracks are influenced by the difference between the coefficient of thermal expansion (CTE) of epoxy resin and that of the chip.