Microscopic Features of Canine Renal Dysplasia

Abstract

Abstract. Forty-five cases of renal dysplasia in dogs are examined. Microscopic lesions of dysplasia include asynchronous differentiation of nephrons, persistent mesenchyme, persistent metanephric ducts, atypical tubular epithelium, and dysontogenic metaplasia. These may be distinguished from secondary lesions including compensatory hypertrophy and hyperplasia of the nephron and a variety of degenerative and inflammatory lesions. Although morphological features of renal dysplasia in dogs differ somewhat from those in man, microscopic criteria used in the diagnosis of human dysplasia may be useful when applied to the dog.

Renal dysplasia in a Boxer dog: case report

“…Macro and microscopic alterations observed in this animal have been described in several other cases of renal dysplasia in dogs (Picut and Lewis, 1987;Lobetti et al, 1996;Hoppe and Karlstam, 2000;Peeters et al, 2000), although there are few reports including Boxer dog (Hoppe and Karlstam, 2000;Peeters et al, 2000).…”

“…Picut and Lewis (1987) proposed five criteria as primary renal dysplasia alterations in dogs. The dog described in this study presented three of them (asynchronic differentiation of nephrons, persistent mesenchyme, and atypical tubular epithelium), which were sufficient for the establishment of the renal dysplasia diagnosis, while the other criteria (persistent metanephric ducts and dysontogenic metaplasia) were not observed.…”

“…Compensatory lesions, such as hypertrophy and hyperplasia of glomerular tufts and tubules, may also be observed, as well as several types of degenerative and inflammatory lesions (Picut and Lewis, 1987). This paper describes a case of renal dysplasia with significant fibrous osteodystrophy brown tumor type in the maxillaries of a female Boxer dog.…”

“…In most cases, it is characterized by the presence of inadequate structures for the stage of development of the organism or the development of abnormal structures (Maxie, 1993;Lees, 1996). It is a common cause of renal insufficiency in dogs, being described in the following breeds: Lhasa Apso, Shih Tzu, Great Dane, Samoyed, Alaskan Malamute, King Charles Spaniel, Bulldog (Picut and Lewis, 1987), Labrador Retriever (Sarkiala et al, 1994), Rhodesian Ridgeback (Lobetti et al, 1996), Boxer and Finnish Harriers (Hoppe and Karlstam, 2000), Boxer, Rottweiler, Collie, and Irish Wolfhound (Peeters et al, 2000).…”

“…The age of the diseased animals ranged from one month to 10 years (Picut and Lewis, 1987;Hoppe et al, 1990;Lees, 1996;Hoppe and Karlstam, 2000), but in general, the clinical evidences start being observed before the animal reaches the age of two years (Hoppe et al, 1990;Lees, 1996;Hoppe and Karlstam, 2000).…”