Congenital Kidney Diseases

Lees, George E.

doi:10.1002/9781118785546.ch56

Cited by 4 publications

(4 citation statements)

References 68 publications

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“…The most common genetic disease in cats is autosomal dominant polycystic kidney disease (Figure 2), which in the past has affected up to 38% of Persian and Persian-cross cats (recent data suggest the prevalence is lower as a result of selective breeding efforts). 4 Other congenital feline kidney diseases are renal amyloidosis in Abyssinian, Siamese and Oriental cats, 4 glomerular disease in Abyssinian cats 5 and juvenile renal dysplasia. 6…”

Section: Aetiology Of Feline Ckdmentioning

confidence: 99%

Feline CKD

Reynolds

Lefebvre

2013

Journal of Feline Medicine and Surgery

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Section: Aetiology Of Feline Ckdmentioning

confidence: 99%

Feline CKD

Reynolds

Lefebvre

2013

Journal of Feline Medicine and Surgery

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“…Concurrent fibrosis is almost always present to varying degrees. 4 Additional discernible, inciting, and perpetuating causes of CKD include pyelonephritis, nephrolithiasis or ureterolithiasis, infarctions, lymphoma, glomerulonephritis, and incomplete resolution of acute renal failure. The typical location and specific characteristics of the histopathologic lesions vary with species.…”

Section: Etiologymentioning

confidence: 99%

Chronic Kidney Disease

Langston¹,

Eatroff²

2015

Small Animal Critical Care Medicine

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“…Em cães, a doença enquadra-se como um tipo de nefropatia juvenil (Lees 2007) que culmina com insuficiência renal entre os três meses e três anos de idade (Lees 2011). Na displasia renal os rins assemelham-se aos de cães idosos com nefropatia crônica e o diagnóstico é baseado em critérios histológicos que distinguem as lesões primárias das secundárias, incluindo respostas compensatórias à lesão (Picut & Lewis 1987b).…”

Section: Introductionunclassified

Achados patológicos em caninos com displasia renal no Sul do Brasil

et al. 2014

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RESUMO.-A displasia renal resulta de um distúrbio na nefrogênese, com diferenciação anormal dos rins, podendo ser unilateral ou bilateral, e causa insuficiência renal em cães jovens. Qualquer agente agressor, incluindo vírus, pode causar a lesão até três meses após o nascimento, quando encerra o desenvolvimento embrionário do néfron. Foram diagnosticados 11 casos de displasia renal dentre 186 casos de cães com insuficiência renal de um total de 5.846 cães submetidos à necropsia no Setor de Patologia Veterinária da Universidade Federal do Rio Grande do Sul no período 2002-2013. Amostras teciduais coletadas na necropsia foram fixadas em 10% de formol e coradas com hematoxilina e eosina (HE) e tricrômico de Masson. Na necropsia, os rins estavam pálidos, diminuídos de tamanho, irregulares e firmes, com diâmetro da cortical diminuído. Alguns ainda eram císticos e apresentavam estriações brancacentas paralelas dispostas radialmente na medular. Ao exame histológi-co os rins exibiam lesões primárias e secundárias. As lesões primárias identificadas foram glomérulos e túbulos fetais, diminuição quantitativa de glomérulos, túbulos adenomatosos e persistência de ductos metanéfricos. Renal dysplasia results from a disturbance which occurs during nephrogenesis. The disease may be unilateral or bilateral, and leads to abnormal kidney differentiation leading to renal failure in young dogs. Several agents, including viruses, can cause the dysplasia till three months after birth, when the early nephron formation of the developing kidney is completed. Eleven renal dysplasia cases were diagnosed in 186 dogs with renal failure of 5,846 dogs necropsied in the Veterinary Pathology Sector, Federal University of Rio Grande do Sul, in the period 2002-2013. Tissue samples collected during necropsy were fixed in 10% formaldehyde and stained with hematoxylin-eosin (HE) and Masson's trichrome protocol. Upon necropsy, kidneys were pale, smaller than normal, irregular and firm, and presented lower cortex diameter. Some exhibited cysts and whitish, parallel radially arranged striae in the medulla. Primary and secondary renal lesions were observed during histological examination. Primary lesions included fetal glomeruli and tubules, quantitative reduction in glomeruli, adenomatous tubules, and persistence of metanephric ducts. As for secondary lesions, Masson trichrome staining revealed intense interstitial fibrosis in all cases; furthermore, dilation of tubules and of Bowman's capsules, glomerular atrophy, and glomerulosclerosis were observed. Even though most cases were associated with breed, the results obtained indicate high prevalence of renal dysplasia in mixed-breed dogs, possibly because they were the majority of animals referred for necropsy. Although primary lesions were easily identified using HE, Masson's trichrome protocol is useful to characterize the extent of fibrosis.

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Congenital Kidney Diseases

Cited by 4 publications

References 68 publications

Feline CKD

Feline CKD

Chronic Kidney Disease

Achados patológicos em caninos com displasia renal no Sul do Brasil

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