Microscale hydrogels for medicine and biology: synthesis, characteristics and applications

Rivest, Christopher; Morrison, David W. G.; Ni, Bin; Rubin, Jamie; Yadav, Vikramaditya G.; Mahdavi, Alborz; Karp, Jeffrey M.; Khademhosseini, Ali

doi:10.2140/jomms.2007.2.1103

Cited by 66 publications

(43 citation statements)

References 61 publications

(69 reference statements)

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“…80 These techniques offer the ability to prepare controlled shape microscale hydrogel beads, even non-spherical objects, although batch process are difficult to scale up. 90 …”

Section: Methods Of Hydrogel Bead-generationmentioning

confidence: 99%

Progress technology in microencapsulation methods for cell therapy

Rabanel

Banquy

Zouaoui

et al. 2009

Biotechnology Progress

122

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Cell encapsulation in microcapsules allows the in situ delivery of secreted proteins to treat different pathological conditions. Spherical microcapsules offer optimal surface-to-volume ratio for protein and nutrient diffusion, and thus, cell viability. This technology permits cell survival along with protein secretion activity upon appropriate host stimuli without the deleterious effects of immunosuppressant drugs. Microcapsules can be classified in 3 categories: matrix-core/shell microcapsules, liquid-core/shell microcapsules, and cells-core/shell microcapsules (or conformal coating). Many preparation techniques using natural or synthetic polymers as well as inorganic compounds have been reported. Matrix-core/shell microcapsules in which cells are hydrogel-embedded, exemplified by alginates capsule, is by far the most studied method. Numerous refinement of the technique have been proposed over the years such as better material characterization and purification, improvements in microbead generation methods, and new microbeads coating techniques. Other approaches, based on liquid-core capsules showed improved protein production and increased cell survival. But aside those more traditional techniques, new techniques are emerging in response to shortcomings of existing methods. More recently, direct cell aggregate coating have been proposed to minimize membrane thickness and implants size. Microcapsule performances are largely dictated by the physicochemical properties of the materials and the preparation techniques employed. Despite numerous promising pre-clinical results, at the present time each methods proposed need further improvements before reaching the clinical phase.

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“…80 These techniques offer the ability to prepare controlled shape microscale hydrogel beads, even non-spherical objects, although batch process are difficult to scale up. 90 …”

Section: Methods Of Hydrogel Bead-generationmentioning

confidence: 99%

Progress technology in microencapsulation methods for cell therapy

Rabanel

Banquy

Zouaoui

et al. 2009

Biotechnology Progress

122

View full text Add to dashboard Cite

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“…In tissue engineering, alginate hydrogels are increasingly used as biomaterials to develop new cell delivery methods as well as support matrices [Augst et al 2006;Yeh et al 2006;Rivest et al 2007]. It is expected that these biomaterials play the role of an artificial extracellular matrix that will surround living tissues and provide space for repair, regeneration, or growth of new tissue as well as offering mechanical support and traction.…”

Section: Multiscale Approaches: From Cell Mechanics To Collective Tismentioning

confidence: 99%

Continuum-based computational models for cell and nuclear mechanics

Vaziri

Gopinath

Deshpande

2007

JOMMS

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Deciphering the relationship between cellular processes and the structure of living cells is a key step toward understanding and predicting cell functions with direct implications for understanding human health and disease. The active nature of these cellular processes, which span several decades of spatial and temporal scales, pose significant challenges to unraveling this complex structure-function paradigm.Complementing novel experimental techniques with robust computational approaches capable of modeling mechanical response at varying scales provides new avenues to resolving this paradigm. We provide an overview of continuum-based computational approaches used in studying and interpreting responses of individual cells and nuclei, we outline techniques used for measuring the mechanical characteristics of living cells, and we discuss some of the key insights provided by these approaches.

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“…Microscale hydrogels have been widely employed as a drug delivery platform in that they confer controllable and sustainable drug release profiles as well as tunable chemical and mechanical properties [1][2][3] . In particular, the colloidal microgels exhibit many advantages as a vehicle for drug delivery due to their rapid responsiveness to external stimuli and suitable injectability to local tissue in a minimally invasive manner 4 .…”

Section: Introductionmentioning

confidence: 99%

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Sung

Shaffer

Sittek

et al. 2016

JoVE

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Magnetically-responsive nano/micro-engineered biomaterials that enable a tightly controlled, on-demand drug delivery have been developed as new types of smart soft devices for biomedical applications. Although a number of magnetically-responsive drug delivery systems have demonstrated efficacies through either in vitro proof of concept studies or in vivo preclinical applications, their use in clinical settings is still limited by their insufficient biocompatibility or biodegradability. Additionally, many of the existing platforms rely on sophisticated techniques for their fabrications. We recently demonstrated the fabrication of biodegradable, gelatin-based thermo-responsive microgel by physically entrapping poly(N-isopropylacrylamide-co-acrylamide) chains as a minor component within a three-dimensional gelatin network. In this study, we present a facile method to fabricate a biodegradable drug release platform that enables a magneto-thermally triggered drug release. This was achieved by incorporating superparamagnetic iron oxide nanoparticles and thermo-responsive polymers within gelatin-based colloidal microgels, in conjunction with an alternating magnetic field application system. Video LinkThe video component of this article can be found at

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Microscale hydrogels for medicine and biology: synthesis, characteristics and applications

Cited by 66 publications

References 61 publications

Progress technology in microencapsulation methods for cell therapy

Progress technology in microencapsulation methods for cell therapy

Continuum-based computational models for cell and nuclear mechanics

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

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