Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Abstract

Magnetically-responsive nano/micro-engineered biomaterials that enable a tightly controlled, on-demand drug delivery have been developed as new types of smart soft devices for biomedical applications. Although a number of magnetically-responsive drug delivery systems have demonstrated efficacies through either in vitro proof of concept studies or in vivo preclinical applications, their use in clinical settings is still limited by their insufficient biocompatibility or biodegradability. Additionally, many of the existing platforms rely on sophisticated techniques for their fabrications. We recently demonstrated the fabrication of biodegradable, gelatin-based thermo-responsive microgel by physically entrapping poly(N-isopropylacrylamide-co-acrylamide) chains as a minor component within a three-dimensional gelatin network. In this study, we present a facile method to fabricate a biodegradable drug release platform that enables a magneto-thermally triggered drug release. This was achieved by incorporating superparamagnetic iron oxide nanoparticles and thermo-responsive polymers within gelatin-based colloidal microgels, in conjunction with an alternating magnetic field application system. Video LinkThe video component of this article can be found at

Fundamentals and applications of acrylamide based microgels and their hybrids: a review

“…Different temperature and pH responsive microgels based on acrylamide moieties have been reported for controlled drug delivery to target cells. 11,92 Sung et al reported crosslinked gelatin based microgels loaded with P(NIPAM-Am) polymer chain as biocompatible and temperature controlled drug delivery system of bovine serum albumin (BSaN). 11 They investigated the kinetics of release of BSaN from aforementioned microgel system under heating and cooling cycles at 22 and 42 C and reported that more than 60% drug can be released from carrier aer four heating and cooling cycles within 3 hours while only 10% release is obtained at constant temperature of 22 C in the same time.…”

“…A rapid delivery of Indomethacin drug from P(NIPAM-Am-HEA) microgel particles with 100% release within just 100 minutes has been reported by Fundueanu et al 16 but this study was carried out in methanol instead of aqueous medium which limits its biomedical practical applications. A lot of many other publications on drug delivery systems based on Nipam and Am are available in scientic literature 75,92,93 but acrylamide unit of such kind of microgels is toxic and its toxicity has not been properly addressed in this literature. The low level biodegradability and biocompatibility makes these microgels less desired systems for targeted drug delivery because its long term storage in body causes cytotoxicity.…”

Magnetic microgels and nanogels: Physical mechanisms and biomedical applications

“…Furthermore, a hybrid MG device that combines biodegradability and magnetic field-responsivity has been developed. 150 The efficiency of intracellular delivery of nucleic acids can be significantly enhanced by using magnetic force. Among several in vitro studies, the experiment of Deka et al 152 is an interesting example.…”

Optimization of Field-Free Point Position, Gradient Field and Ferromagnetic Polymer Ratio for Enhanced Navigation of Magnetically Controlled Polymer-Based Microrobots in Blood Vessel

“…These carriers include both organic and inorganic materials. Some are created from metals, while others are made from polymers [ 3 , 7 , 8 ]. Different approaches have been suggested for steering these TDD vehicles; the use of acoustic radiation force, thermo-electromagnetically reacting bilayer-structured microrobots, octagram-shaped microgrippers, and macrophage-based microrobots have been proposed [ 9 , 10 , 11 ].…”