Microscale granulation in a fluid bed powder processor using electrostatic atomisation

Kivikero, Niina; Murtomaa, Matti; Ingelbeen, Brecht; Antikainen, Osmo; Räsänen, Eetu; Mannermaa, Jukka-Pekka; Juppo, Anne

doi:10.1016/j.ejpb.2008.07.009

Cited by 13 publications

(8 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the factors that affect the size and strength of granule formed is the concentration in binder solution. It has been reported that increase in the binder concentration of binder solution will increase the size of granules (Kivikero 2010;Patel et al 2010). As the drying process is occurred simultaneously in fluidized bed granulator, the solvent evaporates and creates a stronger liquid bonding and steady agglomerates when binder solution with higher concentration is applied.…”

Section: Introductionmentioning

confidence: 99%

Fluidized Bed Granulation Parameters Effect on Urea Granule Physical Properties

Dimin

Loh

Jamli

et al. 2019

JAFM

View full text Add to dashboard Cite

The aim of this study is to determine the effect of different airflow patterns and process conditions on the physical properties of granules produced using fluidized bed granulation technique. It was observed that spiral airflow was the most important factor to produce granules with required size and density under similar process conditions if compared with normal airflow. From ANOVA, binder spray pressure and bag shake duration showed the strongest influence on hardness of granules on both types of airflow patterns. Optimization studies for spiral and normal airflow proved that granules with desired density and hardness can be produced at middle level of wind velocity and binder spray pressure together with high level bag shake duration. For spiral airflow, the optimum value for wind velocity, binder spray pressure and bag shake duration was 28 m/s, 0.31 MPa and 60 s respectively; for normal airflow, it was 25 m/s, 0.20 MPa and 15 s respectively.

show abstract

Section: Introductionmentioning

confidence: 99%

Fluidized Bed Granulation Parameters Effect on Urea Granule Physical Properties

Dimin

Loh

Jamli

et al. 2019

JAFM

View full text Add to dashboard Cite

show abstract

“…(Yu, et al 2010, Yu, et al 2013. Some more specific applications are in a low-cost device for detection of infectious bacteria, granulation screening of pharmaceutical tablet fillers, photocatalytic reactors and compact carbon dioxide HVAC units (Kivikero, et al 2009, Li, et al 2017, Pereiro, et al 2017, Yang, et al 2016. However, in many applications circulation of particles is required, e.g.…”

Section: Introductionmentioning

confidence: 99%

Study of Transitional Velocities of Solid–Liquid Micro-circulating Fluidized Beds by Visual Observation

Nascimento

Reay

Zivkovic

2018

J. Chem. Eng. Japan / JCEJ

View full text Add to dashboard Cite

Solid-liquid micro-fluidised beds (FBs), i.e. fluidisation of micro-particles in sub-centimetre beds, hold promise of applications in the microfluidics and micro-process technology context. This is mainly due to fluidised particles providing enhancement of mixing, mass and heat transfer under the low Reynolds number flows that dominate in micro-devices. Albeit there are quite a few studies of solid-liquid micro-fluidised beds, we are presenting the first study of a micro-circulating fluidised bed. The present experimental research was performed in a micro-circulating fluidised bed which was made by micro-machining channels of 1mm 2 cross section in Perspex. PMMA and soda lime glass micro-particles were used as the fluidised particles and tap water as the fluidising liquid to study flow regime transition for this micro-circulating fluidised bed. The results are in line with macroscopic observation that the critical transition velocity from fluidization to circulating regime is very dependent on solid inventory but once the inventory is high enough it is approximately equal to the particle terminal velocity. However, the transitional velocity is a weakly dependent on wall effect and surface forces confirming the importance of these two properties in a micro-fluidised bed systems. Similarly the transitional velocity to transporting regime is a strong function of surface forces. Finally, combining these results with our previous result on conventional fluidization indicated that map of solid-liquid fluidisation in a micro-circulating fluidised bed system is constructed showing conventional fluidisation, circulating fluidisation and a transport regime.

show abstract

“…-Flexibility and versatility with various and simple setup configurations for diverse purposes (e.g., using single, coaxial dual or tricapillary nozzle) to prepare micro-and nanoparticles with controllable compositions, customized microstructures, and tailored properties of size, morphology, and shape for a variety of biomedical applications. -The EHDA principle can also be simply incorporated into the configuration of different techniques (fluid bed granulation, 10 spray drying, 11 …”

Section: Introductionmentioning

confidence: 99%

Pharmaceutical Applications of Electrospraying

Nguyen

Clasen

Mooter

2016

Journal of Pharmaceutical Sciences

154

128

View full text Add to dashboard Cite

The electrohydrodynamic atomization technique, or simply called electrospraying, has been extensively studied for biomedical as well as for pharmaceutical applications over the past years. The simplicity, flexibility, and efficiency of producing particles at the microscale or nanoscale, with tailored size, shape, morphology, and microstructure, make electrospraying to become one of the most promising and well-practiced approaches to be applied in many biomedical and pharmaceutical fields, from improving the bioavailability of poorly aqueous soluble drugs, preparing targeted drug delivery systems, and controllable drug release systems to delivering sensitive therapeutic agents such as protein-based drugs or even living cells. Nevertheless, some issues still remain with respect to low throughput as well as the complex interplay between a great number of processing and formulation factors. A comprehensive understanding of these fundamental aspects is essential for the successful application of electrospraying for the production of particulate formulations with desired properties.

show abstract

Microscale granulation in a fluid bed powder processor using electrostatic atomisation

Cited by 13 publications

References 21 publications

Fluidized Bed Granulation Parameters Effect on Urea Granule Physical Properties

Fluidized Bed Granulation Parameters Effect on Urea Granule Physical Properties

Study of Transitional Velocities of Solid–Liquid Micro-circulating Fluidized Beds by Visual Observation

Pharmaceutical Applications of Electrospraying

Contact Info

Product

Resources

About